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公开(公告)号：US12071642B2
公开(公告)日：2024-08-27
申请号：US18462237
申请日：2023-09-06
CPC分类号： C12N9/2414 , A61K38/47 , A61P1/18 , C12Y302/01001
摘要： The present invention provides engineered amylase polypeptides and compositions thereof. The engineered amylase polypeptides have been optimized to provide improved thermostability, protease stability, and stability under a range of pH conditions, including acidic (pH
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公开(公告)号：US20220090039A1
公开(公告)日：2022-03-24
申请号：US17460141
申请日：2021-08-27
发明人： Chinping Chng , Nikki Dellas , Ravi David Garcia , Moulay Hicham Alaoui Ismaili , Kristen Jean Vallieu , Kerryn McCluskie
摘要： The present invention provides engineered protease polypeptides and compositions thereof. The engineered protease polypeptides have been optimized to provide improved activity, improved thermostability, protease stability, autolytic stability, and stability under a range of pH conditions, including acidic (pH 7) conditions. The invention also relates to the use of the compositions comprising the engineered protease polypeptides for therapeutic and/or nutritional purposes. The present invention also provides polynucleotides encoding the engineered protease polypeptides, as well as methods for making the engineered polynucleotides and protease polypeptides.
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公开(公告)号：US20220090038A1
公开(公告)日：2022-03-24
申请号：US17460147
申请日：2021-08-27
摘要： The present invention provides engineered amylase polypeptides and compositions thereof. The engineered amylase polypeptides have been optimized to provide improved thermostability, protease stability, and stability under a range of pH conditions, including acidic (pH
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公开(公告)号：US11959108B2
公开(公告)日：2024-04-16
申请号：US17460141
申请日：2021-08-27
发明人： Chinping Chng , Nikki Dellas , Ravi David Garcia , Moulay Hicham Alaoui Ismaili , Kristen Jean Vallieu , Kerryn McCluskie
摘要： The present invention provides engineered protease polypeptides and compositions thereof. The engineered protease polypeptides have been optimized to provide improved activity, improved thermostability, protease stability, autolytic stability, and stability under a range of pH conditions, including acidic (pH 7) conditions. The invention also relates to the use of the compositions comprising the engineered protease polypeptides for therapeutic and/or nutritional purposes. The present invention also provides polynucleotides encoding the engineered protease polypeptides, as well as methods for making the engineered polynucleotides and protease polypeptides.
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公开(公告)号：US11767519B2
公开(公告)日：2023-09-26
申请号：US17460147
申请日：2021-08-27
CPC分类号： C12N9/2414 , A61K38/47 , A61P1/18 , C12Y302/01001
摘要： The present invention provides engineered amylase polypeptides and compositions thereof. The engineered amylase polypeptides have been optimized to provide improved thermostability, protease stability, and stability under a range of pH conditions, including acidic (pH
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公开(公告)号：US20240026326A1
公开(公告)日：2024-01-25
申请号：US18462237
申请日：2023-09-06
CPC分类号： C12N9/2414 , A61P1/18 , A61K38/47 , C12Y302/01001
摘要： The present invention provides engineered amylase polypeptides and compositions thereof. The engineered amylase polypeptides have been optimized to provide improved thermostability, protease stability, and stability under a range of pH conditions, including acidic (pH
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公开(公告)号：US20210062168A1
公开(公告)日：2021-03-04
申请号：US17005913
申请日：2020-08-28
发明人： Chinping Chng , William Casey Hallows , Judy Victoria Antonio Viduya , Nikki Dellas , Stephanie Sue Galanie , Kristen Jean Vallieu
摘要： The present invention provides engineered lipase polypeptides and compositions thereof. The engineered lipase polypeptides have been optimized to provide improved thermostability, protease stability, and stability under a range of pH conditions, including acidic (pH 7) conditions. The invention also relates to the use of the compositions comprising the engineered lipase polypeptides for therapeutic and/or nutritional purposes. The present invention also provides polynucleotides encoding the engineered lipase polypeptides, as well as methods for making the engineered polynucleotides and lipase polypeptides.
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公开(公告)号：US11987823B2
公开(公告)日：2024-05-21
申请号：US17005913
申请日：2020-08-28
发明人： Chinping Chng , William Casey Hallows , Judy Victoria Antonio Viduya , Nikki Dellas , Stephanie Sue Galanie , Kristen Jean Vallieu
CPC分类号： C12N9/20 , A61K9/4883 , A61K38/465 , A61P5/48
摘要： The present invention provides engineered lipase polypeptides and compositions thereof. The engineered lipase polypeptides have been optimized to provide improved thermostability, protease stability, and stability under a range of pH conditions, including acidic (pH 7) conditions. The invention also relates to the use of the compositions comprising the engineered lipase polypeptides for therapeutic and/or nutritional purposes. The present invention also provides polynucleotides encoding the engineered lipase polypeptides, as well as methods for making the engineered polynucleotides and lipase polypeptides.
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公开(公告)号：US20240263156A1
公开(公告)日：2024-08-08
申请号：US18630219
申请日：2024-04-09
发明人： Chinping Chng , William Casey Hallows , Judy Victoria Antonio Viduya , Nikki Dellas , Stephanie Sue Galanie , Kristen Jean Vallieu
CPC分类号： C12N9/20 , A61K9/4883 , A61K38/465 , A61P5/48
摘要： Engineered lipase polypeptides have been optimized to provide improved thermostability, protease stability, and stability under a range of pH conditions, including acidic (pH 7) conditions. Compositions containing the engineered lipase polypeptides can be used for therapeutic and/or nutritional purposes. Polynucleotides encoding the engineered lipase polypeptides are also provided, as well as methods for making the engineered polynucleotides and lipase polypeptides.
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公开(公告)号：US20240263154A1
公开(公告)日：2024-08-08
申请号：US18628461
申请日：2024-04-05
申请人： Codexis, Inc.
发明人： Mathew G. Miller , Vesna Mitchell , Jovana Nazor , Donald S. Baskerville , Nikki Dellas , David Elgart , Jonathan Vroom , Sandy M. Gomes , Nandhitha Subramanian , Ericka Bermudez
IPC分类号： C12N9/12
CPC分类号： C12N9/1252
摘要： The present invention provides engineered DNA polymerase polypeptides and compositions thereof, as well as polynucleotides encoding the engineered DNA polymerase polypeptides. The invention also provides methods for use of the compositions comprising the engineered DNA polymerase polypeptides for diagnostic and other purposes.
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