公开(公告)号：US20230183790A1

公开(公告)日：2023-06-15

申请号：US18046893

申请日：2022-10-14

申请人： Codexis, Inc.

发明人： Ericka Bermudez ,  David Elgart ,  Mathew G. Miller ,  Jovana Nazor ,  Zhe Rui ,  Nandhitha Subramanian

IPC分类号： C12Q1/6848 ,  C12N9/12 ,  C12Q1/6851

CPC分类号： C12Q1/6848 ,  C12N9/1276 ,  C12Y207/07049 ,  C12Q1/6851

摘要： The present disclosure relates to recombinant reverse transcriptase polypeptides and compositions thereof, as well as polynucleotides encoding the recombinant reverse transcriptase polypeptides. The disclosure also provides methods for using the recombinant reverse transcriptase polypeptides and compositions thereof for diagnostic and as molecular biological tools.

公开(公告)号：US20200339973A1

公开(公告)日：2020-10-29

申请号：US16927129

申请日：2020-07-13

申请人： Codexis, Inc.

发明人： Oscar Alvizo ,  David Elgart ,  Robert Kevin Orr ,  James Nicholas Riggins ,  Anna Fryszkowska ,  Katrina W. Lexa ,  Xiang Yi ,  Da Duan ,  Courtney Dianne Moffett ,  Nikki Dellas ,  Vesna Mitchell

IPC分类号： C12N9/84 ,  C07K14/62 ,  C12P21/02

摘要： The present invention provides engineered penicillin G acylase (PGA) enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, and methods of using the engineered PGA enzymes.

公开(公告)号：US10533168B2

公开(公告)日：2020-01-14

申请号：US16367640

申请日：2019-03-28

申请人： Codexis, Inc.

发明人： Gjalt W. Huisman ,  Nicholas J. Agard ,  David Elgart ,  Xiyun Zhang

IPC分类号： A61K38/48 ,  C12N9/88 ,  A61K38/51 ,  A61K31/122 ,  C12P13/22 ,  C12P7/42 ,  C12Q1/527

摘要： The present invention provides engineered tyrosine ammonia-lyase (TAL) polypeptides and compositions thereof. In some embodiments, the engineered TAL polypeptides have been optimized to provide enhanced catalytic activity while reducing sensitivity to proteolysis and increasing tolerance to acidic pH levels. The invention also provides methods for utilization of the compositions comprising the engineered TAL polypeptides for therapeutic and industrial purposes.

公开(公告)号：US20170159038A1

公开(公告)日：2017-06-08

申请号：US15432429

申请日：2017-02-14

申请人： Codexis, Inc.

发明人： Gjalt W. Huisman ,  Nicholas J. Agard ,  David Elgart ,  Xiyun Zhang

IPC分类号： C12N9/88 ,  C12Q1/527

CPC分类号： C12N9/88 ,  A61K31/122 ,  A61K38/51 ,  C12P7/42 ,  C12P13/225 ,  C12Q1/527 ,  C12Y403/01023 ,  A61K2300/00

摘要： The present invention provides engineered tyrosine ammonia-lyase (TAL) polypeptides and compositions thereof. In some embodiments, the engineered TAL polypeptides have been optimized to provide enhanced catalytic activity while reducing sensitivity to proteolysis and increasing tolerance to acidic pH levels. The invention also provides methods for utilization of the compositions comprising the engineered TAL polypeptides for therapeutic and industrial purposes.

公开(公告)号：US20150125903A1

公开(公告)日：2015-05-07

申请号：US14597013

申请日：2015-01-14

申请人： Codexis, Inc.

发明人： Nicholas John Agard ,  David Elgart ,  Jie Yang ,  Goutami Banerjee ,  Jeanne Bonomo Benoit ,  Dipnath Baidyaroy

IPC分类号： C12P19/14 ,  C12P19/02 ,  C12N9/24

CPC分类号： C12P19/14 ,  C12N9/2402 ,  C12N9/248 ,  C12N9/2482 ,  C12P7/14 ,  C12P7/16 ,  C12P19/02 ,  C12Y302/01008 ,  C12Y302/01037 ,  Y02E50/16

摘要： The present invention provides fungal xylanase and/or xylosidase enzymes suitable for use in saccharification reactions. The present invention provides xylanase and xylosidase enzymes suitable for use in saccharification reactions. The present application further provides genetically modified fungal organisms that produce xylanase(s) and/or xylosidase(s), as well as enzyme mixtures exhibiting enhanced hydrolysis of cellulosic material to fermentable sugars, enzyme mixtures produced by the genetically modified fungal organisms, and methods for producing fermentable sugars from cellulose using such enzyme mixtures. In some embodiments, the xylanase and xylosidase enzyme(s) are M. thermophila enzymes.

摘要翻译： 本发明提供了适用于糖化反应的真菌木聚糖酶和/或木糖苷酶。 本发明提供适用于糖化反应的木聚糖酶和木糖酶。 本申请还提供了生产木聚糖酶和/或木糖苷酶的遗传修饰的真菌生物，以及表现出纤维素材料水解为可发酵糖的酶混合物，由遗传修饰的真菌生物体产生的酶混合物和方法 用于使用这种酶混合物从纤维素生产可发酵糖。 在一些实施方案中，木聚糖酶和木糖苷酶是嗜热嗜热乳杆菌酶。

公开(公告)号：US20230227805A1

公开(公告)日：2023-07-20

申请号：US18158339

申请日：2023-01-23

申请人： Codexis, Inc.

发明人： Oscar Alvizo ,  David Elgart ,  Robert Kevin Orr ,  James Nicholas Riggins ,  Anna Fryszkowska ,  Katrina W. Lexa ,  Xiang Yi ,  Da Duan ,  Courtney Dianne Moffett ,  Nikki Dellas ,  Vesna Mitchell

IPC分类号： C12N9/84 ,  C07K14/62 ,  C12P21/02

CPC分类号： C12N9/84 ,  C07K14/62 ,  C12P21/02 ,  C12Y305/01011 ,  C07K2319/21

摘要： The present invention provides engineered penicillin G acylase (PGA) enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, and methods of using the engineered PGA enzymes.

公开(公告)号：US20220154164A1

公开(公告)日：2022-05-19

申请号：US17537941

申请日：2021-11-30

申请人： Codexis, Inc.

发明人： Jovana Nazor ,  Vesna Mitchell ,  David Elgart ,  Katrina W. Lexa ,  Nikki Dellas ,  Robert Kevin Orr ,  Oscar Alvizo ,  Ravi David Garcia ,  Judy Victoria Antonio Viduya ,  Courtney Dianne Moffett

IPC分类号： C12N9/84 ,  C07K14/62 ,  C12P21/02

摘要： The present invention provides engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.

公开(公告)号：US20210309977A1

公开(公告)日：2021-10-07

申请号：US17345404

申请日：2021-06-11

申请人： Codexis, Inc.

发明人： Mathew G. Miller ,  Vesna Mitchell ,  Jovana Nazor ,  Donald S. Baskerville ,  Nikki Dellas ,  David Elgart ,  Jonathan Vroom ,  Sandy M. Gomes ,  Nandhitha Subramanian ,  Ericka Bermudez

IPC分类号： C12N9/12

摘要： The present invention provides engineered DNA polymerase polypeptides and compositions thereof, as well as polynucleotides encoding the engineered DNA polymerase polypeptides. The invention also provides methods for use of the compositions comprising the engineered DNA polymerase polypeptides for diagnostic and other purposes.

公开(公告)号：US20210054357A1

公开(公告)日：2021-02-25

申请号：US17091479

申请日：2020-11-06

申请人： Codexis, Inc.

发明人： Oscar Alvizo ,  David Elgart ,  Robert Kevin Orr ,  James Nicholas Riggins ,  Anna Fryszkowska ,  Katrina W. Lexa ,  Xiang Yi ,  Da Duan ,  Courtney Dianne Moffett ,  Nikki Dellas ,  Vesna Mitchell

IPC分类号： C12N9/84 ,  C07K14/62 ,  C12P21/02

摘要： The present invention provides engineered penicillin G acylase (PGA) enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, and methods of using the engineered PGA enzymes.

公开(公告)号：US20180320162A1

公开(公告)日：2018-11-08

申请号：US15972919

申请日：2018-05-07

申请人： Codexis, Inc.

发明人： Mathew G. Miller ,  Jonathan Vroom ,  Nikki Dellas ,  Donald S. Baskerville ,  Sandy M. Gomes ,  David Elgart ,  Judy Victoria Antonio Viduya

IPC分类号： C12N9/00 ,  C12P19/34 ,  C12Q1/6806

CPC分类号： C12N9/93 ,  C12P19/34 ,  C12Q1/6806 ,  C12Y605/01001

摘要： The present invention provides engineered ligase polypeptides and compositions thereof, as well as polynucleotides encoding the engineered ligase polypeptides. The invention also provides methods for use of the compositions comprising the engineered ligase polypeptides for diagnostic and other purposes.