公开(公告)号：US20160131580A1

公开(公告)日：2016-05-12

申请号：US14924080

申请日：2015-10-27

Applicant: Colorado State University Research Foundation

Inventor： Kevin L. Lear ,  David S. Dandy ,  Matthew D. Stephens ,  Guangwei Yuan

IPC: G01N21/552 ,  G01N33/543 ,  G01N21/41

CPC classification number: G01N21/552 ,  G01N21/41 ,  G01N33/54373 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08

Abstract: A waveguide sensor capable of direct, real-time detection and monitoring of analytes in the vicinity of the waveguide surface without requiring the tagging or labeling of the analyte, is described. Analytic and numerical calculations have predicted that by locally detecting either changes in the evanescent field or changes in the light coupled out of the waveguide as a result of the presence of the analyte, high detection sensitivity will be able to be achieved.

公开(公告)号：US09176059B2

公开(公告)日：2015-11-03

申请号：US13712425

申请日：2012-12-12

Applicant: Colorado State University Research Foundation

Inventor： Kevin L. Lear ,  David S. Dandy ,  Matthew D. Stephens ,  Guangwei Yuan

IPC: G01N21/00 ,  G01N21/552 ,  G01N33/543

CPC classification number: G01N21/552 ,  G01N21/41 ,  G01N33/54373 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08

Abstract: A waveguide sensor capable of direct, real-time detection and monitoring of analytes in the vicinity of the waveguide surface without requiring the tagging or labeling of the analyte, is described. Analytic and numerical calculations have predicted that by locally detecting either changes in the evanescent field or changes in the light coupled out of the waveguide as a result of the presence of the analyte, high detection sensitivity will be able to be achieved.

Abstract translation: 描述了能够直接，实时地检测和监测波导表面附近的分析物而不需要分析物的标记或标记的波导传感器。 分析和数值计算已经预测，由于分析物的存在，通过局部检测ev逝场的变化或耦合在波导外的光的变化，将能够实现高检测灵敏度。

公开(公告)号：US20230294086A1

公开(公告)日：2023-09-21

申请号：US18016753

申请日：2021-07-29

Applicant: Colorado State University Research Foundation

Inventor： Charles S. Henry ,  Brian J. Geiss ,  David S. Dandy ,  Cody Carrell ,  Jeremy Link ,  Isabelle Samper ,  Ana Sanchez-Cano ,  Ilhoon Jang ,  Zachary Call

IPC: B01L3/00 ,  G01N33/543

CPC classification number: B01L3/5023 ,  G01N33/54388 ,  B01L3/50273 ,  B01L2200/16 ,  B01L2400/0406 ,  B01L2300/069 ,  B01L2300/088

Abstract: An assay device includes a colorimetric testing assembly including a detection area, a fluid inlet, and a microfluidic network including a first path extending to the detection area and a second path extending to the detection area. When a fluid (e.g., a buffer fluid or a combined buffer and sample solution) is provided to the fluid inlet, a first portion of the fluid rehydrates a first dried reagent (e.g., a dried enzyme label) disposed along the first path to produce a first rehydrated reagent and a second portion of the fluid rehydrates a second dried reagent (e.g., a dried substrate) to produce a second rehydrated reagent. The first rehydrated reagent and the second rehydrated reagent are then sequentially delivered to the detection area by capillary-driven flow to perform the assay.

公开(公告)号：US09891167B2

公开(公告)日：2018-02-13

申请号：US14924080

申请日：2015-10-27

Applicant: Colorado State University Research Foundation

Inventor： Kevin L. Lear ,  David S. Dandy ,  Matthew D. Stephens ,  Guangwei Yuan

IPC: G01N33/551 ,  G01N21/552 ,  G01N33/543 ,  G01N21/41

CPC classification number: G01N21/552 ,  G01N21/41 ,  G01N33/54373 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08

Abstract: A waveguide sensor capable of direct, real-time detection and monitoring of analytes in the vicinity of the waveguide surface without requiring the tagging or labeling of the analyte, is described. Analytic and numerical calculations have predicted that by locally detecting either changes in the evanescent field or changes in the light coupled out of the waveguide as a result of the presence of the analyte, high detection sensitivity will be able to be achieved.