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Patent Agency Ranking
1.发明申请Novel Benzimidazole and Benzothiazole Derivatives, Method for Preparing Same, Use Thereof as Drugs, Pharmaceutical Compositions and Novel Use Especially as c-MET Inhibitors 失效新型苯并咪唑和苯并噻唑衍生物，其制备方法，用途为药物，药物组合物和新型用途，特别是作为c-MET抑制剂公开(公告)号：US20080194555A1
公开(公告)日：2008-08-14
申请号：US12054719
申请日：2008-03-25
Applicant: Conception NEMECEK , Francois CLERC
Inventor： Conception NEMECEK , Francois CLERC
IPC: A61K31/5377 , C07D235/30 , C07D417/12 , A61K31/4184
CPC classification number: C07D235/30 , C07D277/82
Abstract: This invention relates to benzimidazole and benzothiazole compounds of formula (I) to methods of preparing such compounds, pharmaceutical compositions comprising such compounds, and to methods of treatment comprising administering of such compounds.
Abstract translation: 本发明涉及式（I）的苯并咪唑和苯并噻唑化合物与制备这些化合物的方法，包含这些化合物的药物组合物以及包括给予这些化合物的治疗方法。
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2.发明申请NOVEL BIS-AZAINDOLE DERIVATIVES, PREPARATION AND PHARMACEUTICAL USE THEREOF AS KINASE INHIBITORS 审中-公开新型双嘧啶衍生物，其作为激酶抑制剂的制备和药物使用公开(公告)号：US20100256141A1
公开(公告)日：2010-10-07
申请号：US12821371
申请日：2010-06-23
Applicant: Conception NEMECEK , William A. METZ , Sylvie WENTZLER , Dominique LESUISSE , Youssef EL-AHMAD
Inventor： Conception NEMECEK , William A. METZ , Sylvie WENTZLER , Dominique LESUISSE , Youssef EL-AHMAD
IPC: A61K31/5377 , C07D471/04 , A61K31/437 , C07D413/14 , C07D403/14 , A61K31/497 , A61P35/00 , A61P3/00 , A61P11/06 , A61P37/08 , A61P7/02 , A61P25/00 , A61P17/06 , A61P19/02 , A61P21/00 , A61P27/02 , C12N9/99
CPC classification number: C07D519/00
Abstract: Disclosed are compounds of formula (I): wherein R1, R2, R3, R4, and R5 have the meanings given in the description, and to salts thereof, pharmaceutical compositions comprising said compounds and the use thereof as protein kinase inhibitors.
Abstract translation: 公开了式（I）化合物：其中R1，R2，R3，R4和R5具有说明书中给出的含义及其盐，包含所述化合物的药物组合物及其作为蛋白激酶抑制剂的用途。
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3.发明申请Novel Bis-Azaindole Derivatives, Preparation And Pharmaceutical Use Thereof As Kinase Inhibitors 失效新型双 - 阿魏那衍生物，其制备和药物用途作为激酶抑制剂公开(公告)号：US20080045561A1
公开(公告)日：2008-02-21
申请号：US11692321
申请日：2007-03-28
Applicant: Conception NEMECEK , William METZ , Sylvie WENTZLER , Dominique LESUISSE , Youssef EL-AHMAD
Inventor： Conception NEMECEK , William METZ , Sylvie WENTZLER , Dominique LESUISSE , Youssef EL-AHMAD
IPC: A61K31/5375 , A61K31/435 , A61P35/00 , C07D413/14 , C07D471/02
CPC classification number: C07D519/00
Abstract: Disclosed are compounds of formula (I): wherein R1, R2, R3, R4, and R5 have the meanings given in the description, and to salts thereof, pharmaceutical compositions comprising said compounds and the use thereof as protein kinase inhibitors.
Abstract translation: 公开了式（I）化合物：其中R1，R2，R3，R4和R5具有说明书中给出的含义及其盐，包含所述化合物的药物组合物及其作为蛋白激酶抑制剂的用途。
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4.发明申请NOVEL 6-TRIAZOLOPYRIDAZINESULFANYL BENZOTHIAZOLE AND BENZIMIDAZOLE DERIVATIVES, METHOD FOR PRODUCTION THEREOF AND APPLICATION AS MEDICAMENTS AND PHARMNACEUTICAL COMPOSITIONS AND NOVEL USE AS MET INHIBITORS 有权新型6-三唑基亚氨基二苯并噻唑和苯并咪唑衍生物，其生产方法及其作为药物和药物组合物的应用和作为抑制剂的新用途公开(公告)号：US20100298315A1
公开(公告)日：2010-11-25
申请号：US12693736
申请日：2010-01-26
Applicant: Eva ALBERT , Eric BACQUE , Conception NEMECEK , Antonio UGOLINI , Sylvie WENTZLER
Inventor： Eva ALBERT , Eric BACQUE , Conception NEMECEK , Antonio UGOLINI , Sylvie WENTZLER
IPC: A61K31/5377 , C07D487/04 , A61K31/5025 , C07D413/14 , A61P35/00 , A61P3/00 , A61P7/02 , A61P11/06 , A61P19/02 , A61P25/00 , A61P17/06 , C12N5/02
CPC classification number: C07D487/04 , A61K31/5025 , C07D277/82 , C07D417/12
Abstract: The disclosure relates to compounds of formula (I): wherein , A, W, X, and Ra are as defined in the disclosure, and salts thereof, and to pharmaceutical compositions comprising said compounds, to processes for preparing them, and to their use as medicaments, in particular as MET inhibitors.
Abstract translation: 本公开涉及式（I）的化合物：其中，A，W，X和Ra如本公开内容所定义，及其盐，以及包含所述化合物的药物组合物，其制备方法及其用途 作为药物，特别是作为MET抑制剂。
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5.发明申请Cyclic Urea Compounds, Preparation Thereof and Pharmaceutical Use Thereof as Kinase Inhibitors 失效循环脲类化合物，其制备方法及其药物用途作为激酶抑制剂公开(公告)号：US20080108654A1
公开(公告)日：2008-05-08
申请号：US11972314
申请日：2008-01-10
Applicant: Marcel PATEK , Anil NAIR , Augustin HITTINGER , Conception NEMECEK , Daniel BOND , Greg HARLOW , Herve BOUCHARD , Jacques MAUGER , Jean-Luc MALLERON , Mark PALERMO , Fahad AL-OBEIDI , Thomas FAITG , Hartmut STROBEL , Sven RUF , Kurt RITTER , Youssef EL-AHMAD , Dominique LESUISSE
Inventor： Marcel PATEK , Anil NAIR , Augustin HITTINGER , Conception NEMECEK , Daniel BOND , Greg HARLOW , Herve BOUCHARD , Jacques MAUGER , Jean-Luc MALLERON , Mark PALERMO , Fahad AL-OBEIDI , Thomas FAITG , Hartmut STROBEL , Sven RUF , Kurt RITTER , Youssef EL-AHMAD , Dominique LESUISSE
IPC: A61K31/47 , C07D401/02 , C07D401/14 , A61K31/444 , A61P11/06 , A61P25/00 , A61P35/00 , C12N9/99 , A61K31/4439
CPC classification number: C07D401/06 , C07D401/14
Abstract: The disclosure relates to a cyclic urea compound of formula I: as defined herein, to the process for its preparation, pharmaceutical composition comprising it and its pharmaceutical use as an inhibitor on a protein kinase. Thus, the compound of formula I is useful for preventing or treating a physiological disorder capable of being modulated by inhibiting the activity of a protein kinase, such as a solid tumor.
Abstract translation: 本公开涉及式I的环脲化合物：如本文所定义，其制备方法，包含其的药物组合物及其作为蛋白激酶上的抑制剂的药物用途。 因此，式I化合物可用于预防或治疗能够通过抑制蛋白激酶如实体瘤的活性而被调节的生理障碍。
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