Patent search ap:"Youssef EL-AHMAD" Page 1

1.

发明授权
Pyrrolo(2,3-b) pyridine derivatives, the preparation and the pharmaceutical use thereof in the form of kinase inhibitors 失效
Title translation: 吡咯（2,3-b）吡啶衍生物，其制备方法及其在激酶抑制剂形式中的用途

公开(公告)号：US07968566B2

公开(公告)日：2011-06-28

申请号：US12410135

申请日：2009-03-24

Applicant: Sylvie Wentzler , Youssef El-Ahmad , Bruno Filoche-Romme , Conception Nemecek , Corinne Venot , Augustin Hittinger

Inventor： Sylvie Wentzler , Youssef El-Ahmad , Bruno Filoche-Romme , Conception Nemecek , Corinne Venot , Augustin Hittinger

IPC: C07D401/14 , A61K31/437

CPC classification number: C07D471/04

Abstract: Novel compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3, R4, R5, and R6 have the meanings given in the description, pharmaceutical compositions comprising said compounds and use thereof as protein kinase inhibitors.

Abstract translation: 式（I）的新型化合物或其药学上可接受的盐，其中R，R 1，R 2，R 3，R 4，R 5和R 6具有说明书中给出的含义，包含所述化合物的药物组合物及其作为蛋白激酶抑制剂的用途。

2.

发明授权
Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors 失效
Title translation: 环状尿素衍生物，其制备方法及其作为激酶抑制剂的药物用途

公开(公告)号：US07759379B2

公开(公告)日：2010-07-20

申请号：US11627518

申请日：2007-01-26

Applicant: Hartmut Strobel , Sven Ruf , Dominique Lesuisse , Conception Nemecek , Youssef El-Ahmad , Stefan Guessregen , Anne Lebrun , Kurt Ritter , Didier Benard , Augustin Hittinger , Hervé Bouchard

Inventor： Hartmut Strobel , Sven Ruf , Dominique Lesuisse , Conception Nemecek , Youssef El-Ahmad , Stefan Guessregen , Anne Lebrun , Kurt Ritter , Didier Benard , Augustin Hittinger , Hervé Bouchard

IPC: C07D239/02 , A61K31/505 , A61P43/00

CPC classification number: C07D403/04

Abstract: The invention relates to compounds of formula (I): in which R1, R2, L1, X, R3, A, R4, R4′, R4″, R4″′, R5, Y and L2 are as herein defined, salts and prodrugs thereof, to their use as protein kinase inhibitors, and to methods of treating diseases comprising adminstration thereof.

Abstract translation: 本发明涉及式（I）化合物：其中R1，R2，L1，X，R3，A，R4，R4'，R4“，R4”'，R5，Y和L2如本文所定义，作为蛋白激酶抑制剂的用途，以及治疗包括其施用的疾病的方法。

3.

发明申请
2-BENZOYLIMIDAZOPYRIDINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF 失效
Title translation: 2-苯甲酰基嘧啶衍生物，其制备和治疗用途

公开(公告)号：US20090143420A1

公开(公告)日：2009-06-04

申请号：US12336989

申请日：2008-12-17

Applicant: Jean-Francois PEYRONEL , Youssef EL-AHMAD

Inventor： Jean-Francois PEYRONEL , Youssef EL-AHMAD

IPC: A61K31/437 , C07D471/04 , A61P25/00 , A61P29/00 , A61P35/00

CPC classification number: C07D471/04

Abstract: The present invention is related to a compound of formula (I) wherein R1, R2, R3, R4 and X are as defined herein, or an acid-addition salt thereof, its preparation and therapeutic use in the treatment or prevention of diseases involving the Nurr-1 nuclear receptors, also known as NR4A2, NOT, TINUR, RNR-1 and HZF3.

Abstract translation: 本发明涉及其中R 1，R 2，R 3，R 4和X如本文所定义的式（I）化合物或其酸加成盐，其在治疗或预防涉及 Nurr-1核受体，也称为NR4A2，NOT，TINUR，RNR-1和HZF3。

4.

发明申请
Novel Sulphur-Containing Cyclic Urea Derivatives, Preparation Thereof and Pharmaceutical Use Thereof as Kinase Inhibitors 审中-公开
Title translation: 新型含硫环状脲衍生物及其制备方法及其药物用途作为激酶抑制剂

公开(公告)号：US20090082329A1

公开(公告)日：2009-03-26

申请号：US12173191

申请日：2008-07-15

Applicant: Frank HALLEY , Youssef EL-AHMAD , Victor CERTAL , Corinne VENOT , Anne DAGALLIER , Hartmut STROBEL , Kurt RITTER , Sven RUF

Inventor： Frank HALLEY , Youssef EL-AHMAD , Victor CERTAL , Corinne VENOT , Anne DAGALLIER , Hartmut STROBEL , Kurt RITTER , Sven RUF

IPC: A61K31/4545 , C07D401/06 , C07D401/14 , C07D403/06 , A61K31/506 , A61K31/496 , A61P3/00 , A61P37/00 , A61P11/00 , A61P35/00 , A61P9/00 , C12N9/99 , A61K31/5377 , C07D403/14 , C07D413/06 , A61K31/4439

CPC classification number: C07D401/06 , C07D401/14 , C07D403/06 , C07D403/14

Abstract: The disclosure relates to compounds of formula (I): wherein Ra, Rb, R, and n are as defined in the disclosure, to pharmaceutical compositions comprising said compounds, and to processes for making and methods of using the same.

Abstract translation: 本公开涉及式（I）化合物：其中Ra，Rb，R和n如本公开所定义，包含所述化合物的药物组合物，及其制备方法及其使用方法。

5.

发明申请
Substituted Pyrroles and Imidazoles, Compositions Containing Same, Manufacturing Process Therefor and Use Thereof 失效
Title translation: 取代的吡咯和咪唑，含有它们的组合物，其制备方法和用途

公开(公告)号：US20080045542A1

公开(公告)日：2008-02-21

申请号：US11832206

申请日：2007-08-01

Applicant: Baptiste RONAN , Frank HALLEY , Catherine SOUAILLE , Fabrice VIVIANI , Youssef EL-AHMAD , Eric BACQUE , Michel TABART

Inventor： Baptiste RONAN , Frank HALLEY , Catherine SOUAILLE , Fabrice VIVIANI , Youssef EL-AHMAD , Eric BACQUE , Michel TABART

IPC: A61K31/40 , A61K31/4439 , A61K31/496 , A61P35/00 , C07D207/34 , C07D401/12 , C07D403/02

CPC classification number: C07D207/34 , C07D233/90

Abstract: The disclosure concerns substituted imidazoles and pyrroles, compositions containing the same, the preparation thereof, and the use thereof as medicaments, particularly as anti-cancer agents.

Abstract translation: 本公开涉及取代的咪唑和吡咯，含有它们的组合物，其制备方法及其作为药物的用途，特别是作为抗癌剂。

6.

发明申请
Novel pyrrolo (2,3-b)pyridine derivatives, the preparation and the pharmaceutical use thereof in the form of kinase inhibitors 失效
Title translation: 新型吡咯（2,3-b）吡啶衍生物，其制备方法及其在激酶抑制剂形式中的用途

公开(公告)号：US20070093480A1

公开(公告)日：2007-04-26

申请号：US11541051

申请日：2006-09-29

Applicant: Sylvie Wentzler , Youssef El-Ahmad , Bruno Filoche-Romme , Conception Nemecek , Corinne Venot , Augustin Hittinger

Inventor： Sylvie Wentzler , Youssef El-Ahmad , Bruno Filoche-Romme , Conception Nemecek , Corinne Venot , Augustin Hittinger

IPC: A61K31/5377 , C07D471/02 , A61K31/4745

CPC classification number: C07D471/04

Abstract: Novel compounds of formula (I): or pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3, R4, R5, and R6 have the meanings given in the description, pharmaceutical compositions comprising said compounds and use thereof as protein kinase inhibitors.

Abstract translation: 式（I）的新型化合物或其药学上可接受的盐，其中R，R 1，R 2，R 3，R 4，R 5和R 6具有说明书中给出的含义，包含所述化合物的药物组合物及其作为蛋白激酶抑制剂的用途。

7.

发明授权
Heterocyclylalkylpiperidine derivatives, their preparation and compositions containing them 失效
Title translation: 杂环基烷基哌啶衍生物，它们的制备方法和含有它们的组合物

公开(公告)号：US06903217B2

公开(公告)日：2005-06-07

申请号：US10607220

申请日：2003-06-27

Applicant: Eric Bacqué , Jean-Christophe Carry , Youssef El-Ahmad , Michel Evers , Philippe Hubert , Jean-Luc Malleron , Serge Mignani , Guy Pantel , Michel Tabart , Fabrice Viviani

Inventor： Eric Bacqué , Jean-Christophe Carry , Youssef El-Ahmad , Michel Evers , Philippe Hubert , Jean-Luc Malleron , Serge Mignani , Guy Pantel , Michel Tabart , Fabrice Viviani

IPC: C07D401/06 , C07D401/14 , C07D409/14 , C07D417/14 , C07D471/02 , C07D215/18 , C07D237/26

CPC classification number: C07D401/06 , C07D401/14 , C07D409/14 , C07D417/14

Abstract: Heterocyclylalkylpiperidine derivatives of general formula (I) in their enantiomeric or diastereoisomeric forms or mixtures of these forms, and/or, where appropriate, in their syn or anti form or a mixture thereof, as well as any salt thereof.

Abstract translation: 通式（I）的杂环基烷基哌啶衍生物在它们的对映体或非对映异构体形式或这些形式的混合物中，和/或在适当的情况下以其顺式或反式或其混合物以及其任何盐。

8.

发明授权
Quinolylpropylpiperidine derivatives, intermediates and compositions containing them, and preparation therefor 失效
Title translation: 醌基丙基哌啶衍生物，含有它们的中间体和组合物及其制备方法

公开(公告)号：US06841562B2

公开(公告)日：2005-01-11

申请号：US10659095

申请日：2003-09-10

Applicant: Eric Bacqué , Antony Bigot , Youssef El Ahmad , Jean-Luc Malleron , Serge Mignani , Baptiste Ronan , Michel Tabart , Fabrice Viviani

Inventor： Eric Bacqué , Antony Bigot , Youssef El Ahmad , Jean-Luc Malleron , Serge Mignani , Baptiste Ronan , Michel Tabart , Fabrice Viviani

IPC: A61P31/04 , C07D211/60 , C07D401/06 , C07D409/14 , A61K31/44 , C07D215/12 , C07D215/18

CPC classification number: C07D401/06 , C07D211/60 , C07D409/14 , Y02P20/55

Abstract: Quinolylpropylpiperidine derivatives of general formula (I) in which R1a is hydrogen, halogen, hydroxyl, amino, alkylamino, dialkylamino, hydroxyamino, alkoxyamino or alkylalkoxyamino and R1b is hydrogen, or R1a and R1b form an oxo, R2 is carboxyl, carboxymethyl or hydroxymethyl, R3 is alkyl either substituted with phenylthio optionally substituted with halogen, hydroxyl, alkyl, alkoxy, trifluoromethyl, trifluoromethoxy, carboxyl, alkoxycarbonyl, cyano or amino, or with cycloalkylthio (3 to 7 members) optionally substituted with halogen or trifluoromethyl, or with heteroarylthio (5 to 6 members and 1 to 4 heteroatoms chosen from N, O and S), optionally substituted with halogen, hydroxyl, alkyl, alkoxy, trifluoromethyl, trifluoromethoxy, carboxyl, alkoxycarbonyl, cyano or amino or R3 is propargyl substituted with phenyl or heteroaryl as defined above, R4 is alkyl, alkenyl-CH2— or alkynyl-CH2—, cycloalkyl or cycloalkylalkyl, in their various isomeric forms, separate or as mixtures, and also their salts, their preparation process and intermediates and the compositions containing them. These novel derivatives are potent antibacterial agents.

Abstract translation: 通式（I）的喹啉基丙基哌啶衍生物，其中R 1a是氢，卤素，羟基，氨基，烷基氨基，二烷基氨基，羟基氨基，烷氧基氨基或烷基烷氧基氨基，R 1b是氢，或者R 1a和R 1b形成氧代，R 2是羧基，羧甲基或羟甲基，羟基，烷基，烷氧基，三氟甲基，三氟甲氧基，羧基，烷氧基羰基，氰基或氨基，或与任选被卤素或三氟甲基取代的环烷硫基（3至7个成员）或与杂芳硫基（羟基，烷基，烷氧基，三氟甲基，三氟甲氧基，羧基，烷氧基羰基，氰基或氨基或R3是被苯基或杂芳基取代的炔丙基，被苯基或杂芳基取代 R4是烷基，烯基-CH 2 - 或炔基-CH 2 - ，环烷基或环烷基烷基，其各种异构体形式，分别或混合物，和它们的盐，它们的制备方法和中间体以及含有它们的组合物。这些新型衍生物是有效的抗菌剂。