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公开(公告)号：US09365546B2
公开(公告)日：2016-06-14
申请号：US14149659
申请日：2014-01-07
IPC分类号： C07D401/14 , A61K31/4412 , C07D413/14 , C07D409/14 , C07D417/14 , A61K45/06
CPC分类号： C07D401/14 , A61K31/444 , A61K31/506 , A61K45/06 , C07D401/04 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present disclosure provides pyridinone-pyridinyl compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and auto-inflammatory disease, having the structure of Formula (I): wherein R1, R2, R3, R4, R5, X and Y are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for treating p38 kinase mediated diseases using the compound.
摘要翻译： 本公开提供了可用于治疗p38激酶介导的疾病（例如淋巴瘤和自身炎性疾病）的吡啶酮 - 吡啶基化合物，其具有式（I）的结构：其中R1，R2，R3，R4，R5，X和Y 在详细描述中定义; 包含至少一种化合物的药物组合物; 以及使用该化合物治疗p38激酶介导的疾病的方法。
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2.发明申请METHYL/DIFLUOROPHENYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS, METHYL-PYRIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS, AND METHYL-PYRIMIDINYL-METHOXY SUBSTITUTED PYRIDINONE-PYRIDINYL COMPOUNDS 有权甲基/二氟代甲氧基取代的吡啶酮 - 吡啶啉化合物，甲基 - 吡啶并 - 甲氧基取代的吡啶酮 - 吡啶基化合物和甲基 - 嘧啶并 - 甲氧基取代的吡啶酮 - 吡啶并[公开(公告)号：US20130274272A1
公开(公告)日：2013-10-17
申请号：US13913350
申请日：2013-06-07
发明人： Shaun R. Selness , Joseph B. Monahan , John F. Schindler , Balekudru Devadas , Susan L. Hockerman
IPC分类号： C07D213/69 , A61K31/444 , A61K45/06 , C07D401/14 , A61K31/506
CPC分类号： C07D213/69 , A61K31/4412 , A61K31/444 , A61K31/506 , A61K45/06 , C07D401/14
摘要： The present disclosure provides methyl/difluorophenyl-methoxy substituted pyridinone-pyridinyl compounds, methyl-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds, and methyl-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and auto-inflammatory disease, having the structure of Formula (I): wherein R1, R2, R3 and X are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for treating p38 kinase mediated diseases using the compound.
摘要翻译： 本公开内容提供甲基/二氟苯基 - 甲氧基取代的吡啶酮 - 吡啶基化合物，甲基 - 吡啶基 - 甲氧基取代的吡啶酮 - 吡啶基化合物和用于治疗p38激酶介导的疾病例如淋巴瘤的甲基 - 嘧啶基 - 甲氧基取代的吡啶酮 - 吡啶基化合物 和自身炎性疾病，具有式（I）的结构：其中R1，R2，R3和X如详细描述中所定义; 包含至少一种化合物的药物组合物; 以及使用该化合物治疗p38激酶介导的疾病的方法。
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公开(公告)号：US20140171450A1
公开(公告)日：2014-06-19
申请号：US14149741
申请日：2014-01-07
IPC分类号： C07D401/14
CPC分类号： C07D401/14 , A61K31/444 , A61K31/506 , A61K45/06 , C07D401/04 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present disclosure provides pyridinone-pyridinyl compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and auto-inflammatory disease, having the structure of Formula (I): wherein R1, R2, R3, R4, R5, X and Y are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for treating p38 kinase mediated diseases using the compound.
摘要翻译： 本公开提供了可用于治疗p38激酶介导的疾病（例如淋巴瘤和自身炎性疾病）的吡啶酮 - 吡啶基化合物，其具有式（I）的结构：其中R1，R2，R3，R4，R5，X和Y 在详细描述中定义; 包含至少一种化合物的药物组合物; 以及使用该化合物治疗p38激酶介导的疾病的方法。
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公开(公告)号：US20140171449A1
公开(公告)日：2014-06-19
申请号：US14149659
申请日：2014-01-07
IPC分类号： C07D401/14
CPC分类号： C07D401/14 , A61K31/444 , A61K31/506 , A61K45/06 , C07D401/04 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present disclosure provides pyridinone-pyridinyl compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and auto-inflammatory disease, having the structure of Formula (I): wherein R1, R2, R3, R4, R5, X and Y are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for treating p38 kinase mediated diseases using the compound.
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5.发明授权4-alkoxy/aralkoxy-5-substituted-pyrrolopyrimidine compounds as TAK1 inhibitors in disease treatment 有权4-烷氧基/芳烷氧基-5-取代的吡咯并嘧啶化合物作为疾病治疗中的TAK1抑制剂公开(公告)号：US09505765B2
公开(公告)日：2016-11-29
申请号：US14417518
申请日：2013-07-26
IPC分类号： C07D487/04 , A61K31/519 , A61K45/06 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04 , A61K31/519 , A61K31/53 , A61K45/06
摘要： 4-alkoxy/aralkoxy-5-substituted-pyrrolopyrimidine compounds, pharmaceutically acceptable salts, solvates and pharmaceutical compositions of compounds embraced by Formula (I), provide a therapeutic benefit to subjects with disease conditions, especially cancer, wherein R1 and R2 are as defined in the detailed description.
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6.发明授权Methyl/difluorophenyl-methoxy substituted pyridinone-pyridinyl compounds, methyl-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds, and methyl-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds 有权甲基/二氟苯基甲氧基取代的吡啶酮 - 吡啶基化合物，甲基 - 吡啶基 - 甲氧基取代的吡啶酮 - 吡啶基化合物和甲基 - 嘧啶基 - 甲氧基取代的吡啶酮 - 吡啶基化合物公开(公告)号：US09359300B2
公开(公告)日：2016-06-07
申请号：US13913350
申请日：2013-06-07
发明人： Shaun R. Selness , Joseph B. Monahan , John F. Schindler , Balekudru Devadas , Susan L. Hockerman
IPC分类号： C07D401/14 , A61K31/4412 , C07D213/69 , A61K31/506 , A61K45/06 , A61K31/444
CPC分类号： C07D213/69 , A61K31/4412 , A61K31/444 , A61K31/506 , A61K45/06 , C07D401/14
摘要： The present disclosure provides methyl/difluorophenyl-methoxy substituted pyridinone-pyridinyl compounds, methyl-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds, and methyl-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and auto-inflammatory disease, having the structure of Formula (I): wherein R1, R2, R3 and X are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for treating p38 kinase mediated diseases using the compound.
摘要翻译： 本公开内容提供甲基/二氟苯基 - 甲氧基取代的吡啶酮 - 吡啶基化合物，甲基 - 吡啶基 - 甲氧基取代的吡啶酮 - 吡啶基化合物和用于治疗p38激酶介导的疾病例如淋巴瘤的甲基 - 嘧啶基 - 甲氧基取代的吡啶酮 - 吡啶基化合物 和自身炎性疾病，具有式（I）的结构：其中R1，R2，R3和X如详细描述中所定义; 包含至少一种化合物的药物组合物; 以及使用该化合物治疗p38激酶介导的疾病的方法。
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7.发明申请4-ALKOXY/ARALKOXY-5-SUBSTITUTED-PYRROLOPYRIMIDINE COMPOUNDS AS TAK1 INHIBITORS IN DISEASE TREATMENT 有权4-ALKOXY / ARALKOXY-5-取代的吡咯烷酮化合物作为TAK1抑制剂在疾病治疗中的作用公开(公告)号：US20150203499A1
公开(公告)日：2015-07-23
申请号：US14417518
申请日：2013-07-26
IPC分类号： C07D487/04 , A61K45/06 , A61K31/53 , A61K31/519
CPC分类号： C07D487/04 , A61K31/519 , A61K31/53 , A61K45/06
摘要： The present disclosure provides 4-alkoxy/aralkoxy-5-substituted-pyrrolopyrimidine compounds, pharmaceutically acceptable salts, solvates and pharmaceutical compositions of compounds embraced by Formula (I), providing a therapeutic benefit to subjects with disease conditions, especially cancer, wherein R1 and R2 are as defined in the detailed description.
摘要翻译： 本公开提供了通过式（I）包含的化合物的4-烷氧基/芳烷氧基-5-取代的吡咯并嘧啶化合物，药学上可接受的盐，溶剂合物和药物组合物，为具有疾病状况，特别是癌症的受试者提供治疗益处，其中R1和 R2如在详细描述中所定义。
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公开(公告)号：US09056110B2
公开(公告)日：2015-06-16
申请号：US13707326
申请日：2012-12-06
IPC分类号： A61K31/513 , A61K45/06 , C07D401/14 , C07D413/14 , C07D409/14 , C07D417/14 , C07D403/14 , C07D239/52
CPC分类号： A61K31/513 , A61K45/06 , C07D239/52 , C07D401/14 , C07D403/14 , C07D409/14 , C07D413/14 , C07D417/14 , A61K2300/00
摘要： The present disclosure provides pyrimidinone-phenyl-pyrimidinyl compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and inflammatory disease, having the structure of Formula (I): wherein R1, R2, R3, R4 and R5 are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for treating p38 kinase mediated diseases using the compound.
摘要翻译： 本公开提供了可用于治疗p38激酶介导的疾病（例如淋巴瘤和炎性疾病）的嘧啶酮 - 苯基 - 嘧啶基化合物，其具有式（I）的结构：其中R 1，R 2，R 3，R 4和R 5如 详细说明; 包含至少一种化合物的药物组合物; 以及使用该化合物治疗p38激酶介导的疾病的方法。
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公开(公告)号：US09365547B2
公开(公告)日：2016-06-14
申请号：US14149741
申请日：2014-01-07
IPC分类号： C07D401/04 , C07D401/14 , A61K31/444 , A61K31/506 , A61P35/00 , C07D413/14 , C07D409/14 , C07D417/14 , A61K45/06
CPC分类号： C07D401/14 , A61K31/444 , A61K31/506 , A61K45/06 , C07D401/04 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present disclosure provides pyridinone-pyridinyl compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and auto-inflammatory disease, having the structure of Formula (I): wherein R1, R2, R3, R4, R5, X and Y are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for treating p38 kinase mediated diseases using the compound.
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公开(公告)号：US20130143906A1
公开(公告)日：2013-06-06
申请号：US13707326
申请日：2012-12-06
IPC分类号： A61K31/513 , A61K45/06 , C07D417/14 , C07D401/14 , C07D239/52 , C07D413/14
CPC分类号： A61K31/513 , A61K45/06 , C07D239/52 , C07D401/14 , C07D403/14 , C07D409/14 , C07D413/14 , C07D417/14 , A61K2300/00
摘要： The present disclosure provides pyrimidinone-phenyl-pyrimidinyl compounds useful in the treatment of p38 kinase mediated diseases, such as lymphoma and inflammatory disease, having the structure of Formula (I): wherein R1, R2, R3, R4 and R5 are as defined in the detailed description; pharmaceutical compositions comprising at least one of the compounds; and methods for treating p38 kinase mediated diseases using the compound.
摘要翻译： 本公开提供了可用于治疗p38激酶介导的疾病（例如淋巴瘤和炎性疾病）的嘧啶酮 - 苯基 - 嘧啶基化合物，其具有式（I）的结构：其中R 1，R 2，R 3，R 4和R 5如 详细说明; 包含至少一种化合物的药物组合物; 以及使用该化合物治疗p38激酶介导的疾病的方法。
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