公开(公告)号：US20010008774A1

公开(公告)日：2001-07-19

申请号：US09780351

申请日：2001-02-12

申请人： Conopco Inc.

发明人： Keith May ,  Michael Evans Prior ,  Ian Richards

IPC分类号： G01N033/558

CPC分类号： G01N33/54366 ,  G01N30/90 ,  G01N33/54386 ,  G01N33/548 ,  G01N33/549 ,  G01N33/558 ,  G01N33/58 ,  G01N33/689 ,  G01N33/76 ,  G01N2800/368 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/962 ,  Y10S435/969 ,  Y10S435/97 ,  Y10S435/975 ,  Y10S436/805 ,  Y10S436/81 ,  Y10S436/814 ,  Y10S436/817 ,  Y10S436/818 ,  Y10S436/906

摘要： An analytical test device useful for example in pregnancy testing, comprises a hollow casing (500) constructed of moisture-impervious solid material, such as plastics materials, containing a dry porous carrier (510) which communicates indirectly with the exterior of the casing via a bibulous sample receiving member (506) which protrudes from the casing such that a liquid test sample can be applied to the receiving member and permeate therefrom to the porous carrier, the carrier containing in a first zone a labelled specific binding reagent is freely mobile within the porous carrier when in the moist state, and in a second zone spatially distinct from the first zone unlabelled specific binding reagent for the same analyte which unlabelled reagent is permanently immobilised on the carrier material and is therefore not mobile in the moist state, the two zones being arranged such that liquid sample applied to the porous carrier can permeate via the first zone into the second zone, and the device incorporating means, such as an aperture (508) in the casing, enabling the extent (if any) to which the labelled reagent becomes bound in the second zone to be observed. Preferably the device includes a removable cap for the protruding bibulous member.

摘要翻译： 可用于例如妊娠试验的分析测试装置包括由不透水的固体材料（例如塑料材料）构成的中空壳体（500），其包含干燥多孔载体（510），所述干燥多孔载体（510）经由壳体的外部经由 吸收样品接收构件（506），其从壳体突出，使得液体测试样品可以施加到接收构件并从其渗透到多孔载体上，在第一区域中包含标记的特异性结合剂的载体可在 多孔载体在处于潮湿状态时，在与第一区空间不同的第二区中，未标记的特异性结合试剂用于相同分析物，未标记的试剂永久地固定在载体材料上，因此在潮湿状态下不能移动， 被布置成使得施加到多孔载体的液体样品可以经由第一区域渗透到第二区域中 装置结合的装置，例如壳体中的孔（508），使得能够观察标记的试剂在第二区域中结合的程度（如果有的话）。 优选地，该装置包括用于突出的吸水构件的可移除盖。

公开(公告)号：US20010041368A1

公开(公告)日：2001-11-15

申请号：US09794061

申请日：2001-02-28

申请人： Conopco Inc.

发明人： Keith May ,  Michael Evans Prior ,  Ian Richards

IPC分类号： G01N033/558

CPC分类号： G01N33/54366 ,  G01N30/90 ,  G01N33/54386 ,  G01N33/548 ,  G01N33/549 ,  G01N33/558 ,  G01N33/58 ,  G01N33/689 ,  G01N33/76 ,  G01N2800/368 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/962 ,  Y10S435/969 ,  Y10S435/97 ,  Y10S435/975 ,  Y10S436/805 ,  Y10S436/81 ,  Y10S436/814 ,  Y10S436/817 ,  Y10S436/818 ,  Y10S436/906

摘要： An analytical test device useful for example in pregnancy testing, comprises a hollow casing (500) constructed of moisture-impervious solid material, such as; plastics materials, containing a dry porous carrier (510) which communicates indirectly with the exterior of the casing via a bibulous sample receiving member (506) which protrudes from the casing such that a liquid test sample can be applied to the receiving member and permeate therefrom to the porous carrier, the carrier containing in a first zone a labelled specific binding reagent is freely mobile within the porous carrier when in the moist state, and in a second zone spatially distinct from the first zone unlabelled specific binding reagent for the same analyte which unlabelled reagent is permanently immobilised on the carrier material and is therefore not mobile in the moist state, the two zones being arranged such that liquid sample applied to the porous carrier can permeate via the first zone into the second zone, and the device incorporating means, such as an aperture (508) in the casing, enabling the extent (if any) to which the labelled reagent becomes bound in the second zone to be observed. Preferably the device includes a removable cap for the protruding bibulous member.

摘要翻译： 例如在妊娠试验中有用的分析测试装置包括由不透水的固体材料构成的中空壳体（500） 塑料材料，其包含干燥的多孔载体（510），所述干燥的多孔载体（510）经由从壳体突出的吸水样品接收构件（506）间接地与壳体的外部连通，使得可以将液体测试样品施加到接收构件并从其渗透 在多孔载体中，当处于潮湿状态时，在第一区域中含有标记的特异性结合试剂的载体在多孔载体内可自由移动，并且在空间上不同于第一区域的第二区域未标记的特异性结合试剂用于相同的分析物， 未标记的试剂永久地固定在载体材料上，因此在潮湿状态下不能移动，这两个区域被布置成使得施加到多孔载体的液体样品可以经由第一区域渗入第二区域，并且装置结合装置， 例如壳体中的孔（508），使得标记的试剂在第二个zo中能够结合的程度（如果有的话） 待观察。 优选地，该装置包括用于突出的吸水构件的可移除盖。