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14 条记录 (耗时 0.025 秒)

    Human choline acetyltransferase
    1.
    发明授权
    Human choline acetyltransferase 失效

    公开(公告)号：US06245540B1

    公开(公告)日：2001-06-12

    申请号：US08464601

    申请日：1995-06-05

    申请人： Peter J. Hudson ,  Wei Wu He ,  Craig A. Rosen ,  Jeannine D. Gocayne

    发明人： Peter J. Hudson ,  Wei Wu He ,  Craig A. Rosen ,  Jeannine D. Gocayne

    IPC分类号： C12N910

    CPC分类号： C12N9/1029 ,  A61K38/00

    摘要： Human choline acetyltransferase polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of cognitive and neurological deficiencies or mental disturbances such as degenerative nervous system disorders, for example, Alzheimer's Disease, ALS and other cholinergic defects, and antagonists for treating Parkinson's Disease and other disorders relating to an over-expression of acetylcholine. Also disclosed are diagnostic methods for detecting a mutation in the human Choline Acetyltransferase nucleic acid sequence.

    Human choline acetyltransferase
    2.
    发明授权
    Human choline acetyltransferase 失效
    人胆碱乙酰转移酶

    公开(公告)号：US06319700B1

    公开(公告)日：2001-11-20

    申请号：US09210993

    申请日：1998-12-15

    申请人： Peter J. Hudson ,  Wei Wu He ,  Craig A. Rosen ,  Jeannine D. Gocayne

    发明人： Peter J. Hudson ,  Wei Wu He ,  Craig A. Rosen ,  Jeannine D. Gocayne

    IPC分类号： C12N910

    CPC分类号： C12N9/1029 ,  A61K38/00

    摘要： Human choline acetyltransferase polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of cognitive and neurological deficiencies or mental disturbances such as degenerative nervous system disorders, for example, Alzheimer's Disease, ALS and other cholinergic defects, and antagonists for treating Parkinson's Disease and other disorders relating to an over-expression of acetylcholine. Also disclosed are diagnostic methods for detecting a mutation in the human Choline Acetyltransferase nucleic acid sequence.

    摘要翻译： 公开了人胆碱乙酰转移酶多肽和编码这种多肽的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种多肽治疗认知和神经缺陷或精神障碍如退行性神经系统疾病例如阿尔茨海默氏病，ALS和其它胆碱能缺陷的治疗方法，以及用于治疗帕金森氏病和其他与 过度表达乙酰胆碱。 还公开了用于检测人胆碱乙酰转移酶核酸序列中的突变的诊断方法。

    Human relaxin polypeptides
    5.
    发明授权
    Human relaxin polypeptides 失效
    人类松弛素多肽

    公开(公告)号：US5179195A

    公开(公告)日：1993-01-12

    申请号：US665129

    申请日：1991-03-06

    申请人： Peter J. Hudson ,  Hugh D. Niall ,  Geoffrey W. Tregear

    发明人： Peter J. Hudson ,  Hugh D. Niall ,  Geoffrey W. Tregear

    IPC分类号： C07K14/64

    CPC分类号： C07K14/64 ,  Y10S530/851 ,  Y10S530/853

    摘要： Genes and DNA transfer vectors for the expression of human preprorelaxin; sub-units thereof, including genes and transfer vectors for expression of human prorelaxin and the individual A, B and C peptide chains thereof; and equivalents of all such genes. Methods for synthesis of the peptides involving recombinant DNA techniques.

    摘要翻译： 用于表达人类前释放蛋白的基因和DNA转移载体; 亚单位，包括人prorelaxin表达的基因和转移载体及其各自的A，B和C肽链; 和所有这些基因的等同物。 涉及重组DNA技术的肽的合成方法。

    Immuno-conjugates and methods for producing them
    8.
    发明授权
    Immuno-conjugates and methods for producing them 有权
    免疫偶联物及其制备方法

    公开(公告)号：US09315581B2

    公开(公告)日：2016-04-19

    申请号：US13383836

    申请日：2010-12-23

    申请人： Peter J. Hudson ,  Debra Tamvakis ,  Michael P. Wheatcroft ,  Fabio Turatti

    发明人： Peter J. Hudson ,  Debra Tamvakis ,  Michael P. Wheatcroft ,  Fabio Turatti

    IPC分类号： A61K51/10 ,  C07K16/30 ,  A61K47/48 ,  A61K49/00 ,  C07K16/32

    CPC分类号： C07K16/30 ,  A61K47/60 ,  A61K49/0002 ,  C07K16/3092 ,  C07K16/32 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/624 ,  C07K2317/626 ,  C07K2319/21

    摘要： The present invention provides an isolated protein comprising an immunoglobulin variable region comprising at least two cysteine residues positioned within framework region (FR) 2 and/or at least two cysteine residues positioned within framework region (FR3), wherein if at least two of the cysteine residues in FR2 and/or FR3 are not conjugated to a compound then an intra-framework disulphide bond is capable of forming between the cysteine residues. Preferably the protein comprises an immunoglobulin heavy chain variable region (VH) and an immunoglobulin light chain variable region (VL), wherein at least one of the variable regions comprises the two cysteine residues. The present invention also provides conjugates of the protein and another compound.

    摘要翻译： 本发明提供了分离的蛋白质，其包含免疫球蛋白可变区，其包含位于框架区（FR）2内的至少两个半胱氨酸残基和/或位于框架区（FR3）内的至少两个半胱氨酸残基），其中如果半胱氨酸 FR2和/或FR3中的残基不与化合物缀合，则骨架内二硫键能够在半胱氨酸残基之间形成。 优选地，蛋白质包含免疫球蛋白重链可变区（VH）和免疫球蛋白轻链可变区（VL），其中至少一个可变区包含两个半胱氨酸残基。 本发明还提供了蛋白质和另一种化合物的缀合物。

    HIGH AVIDITY POLYVALENT AND POLYSPECIFIC REAGENTS
    9.
    发明申请
    HIGH AVIDITY POLYVALENT AND POLYSPECIFIC REAGENTS 审中-公开
    高分子聚合物和聚对苯二甲酸酯试剂

    公开(公告)号：US20080152586A1

    公开(公告)日：2008-06-26

    申请号：US11692643

    申请日：2007-03-28

    申请人： Peter J. Hudson ,  Alex A. Kortt ,  Robert A. Irving ,  John L. Atwell

    发明人： Peter J. Hudson ,  Alex A. Kortt ,  Robert A. Irving ,  John L. Atwell

    IPC分类号： A61K39/395 ,  C07K16/18 ,  A61K49/00 ,  A61K51/00 ,  A61P43/00

    CPC分类号： C07K16/4216 ,  A61K47/6803 ,  A61K47/6817 ,  A61K47/6879 ,  A61K51/109 ,  A61K2039/505 ,  C07K16/1018 ,  C07K2317/622 ,  C07K2317/626

    摘要： This invention provides polyvalent or polyspecific protein complexes, comprising three or more polypeptides which associate to form three or more functional target-binding regions (TBRs), and in which each individual polypeptide comprises two or more immunoglobulin-like domains which are covalently joined together, such that two Ig-like domains in a single polypeptide do not associate with each other to form a TBR. By using a linker peptide of fewer than three amino acid residues the immunoglobulin-like domains of the individual polypeptides are prevented from associating, so that complex formation between polypeptides is favoured. Preferably the polyvalent or polyspecific protein is a trimer or tetramer. The proteins of the invention have specificities which may be the same or different, and are suitable for use as therapeutic, diagnostic or imaging agents.

    摘要翻译： 本发明提供了多价或多特异性蛋白复合物，其包含三个或更多个缔合以形成三个或更多个功能性靶结合区（TBR）的多肽，并且其中每个单个多肽包含共价连接在一起的两个或更多个免疫球蛋白样结构域， 使得单个多肽中的两个Ig样结构域不相互结合以形成TBR。 通过使用少于三个氨基酸残基的接头肽，可以防止单个多肽的免疫球蛋白样结构域缔合，从而有利于多肽之间的复合物形成。 优选地，多价或多特异性蛋白质是三聚体或四聚体。 本发明的蛋白质具有相同或不同的特异性，并且适合用作治疗，诊断或成像剂。