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8 条记录 (耗时 0.034 秒)

    Contryphan peptides
    5.
    发明授权
    Contryphan peptides 有权
    对角han肽

    公开(公告)号：US6153738A

    公开(公告)日：2000-11-28

    申请号：US466138

    申请日：1999-12-21

    申请人： Richard Jacobsen ,  Elsie Jimenez ,  Lourdes J. Cruz ,  Baldomero M. Olivera ,  William R. Gray ,  Michelle Grilley ,  Maren Watkins ,  David R. Hillyard

    发明人： Richard Jacobsen ,  Elsie Jimenez ,  Lourdes J. Cruz ,  Baldomero M. Olivera ,  William R. Gray ,  Michelle Grilley ,  Maren Watkins ,  David R. Hillyard

    IPC分类号： A61K38/00 ,  C07K7/06 ,  C07H21/04

    CPC分类号： C07K7/06 ,  A61K38/00 ,  Y10S530/857

    摘要： The present invention is directed to contryphan peptides having 6-12 amino acids, preferably including one or more D-tryptophan or D-leucine residues. The peptides of the present invention are generically termed "contryphans," although the D-leucine containing contryphans are sometimes referred to as leu-contryphans. More specifically, the present invention is directed to contryphan peptides having the general formula Xaa.sub.1 -Cys-Xaa.sub.2 -Xaa.sub.3 -Xaa.sub.4 -Pro-Xaa.sub.5 -Cys (SEQ ID NO:1), wherein Xaa.sub.1 is any amino acid or des-Xaa.sub.1, Xaa.sub.2 is Pro, 4-trans-hydroxyproline or Val, Xaa.sub.3 is D-Trp, L-Trp, D-Leu or L-Leu, preferably D-Trp or D-Leu, Xaa.sub.4 is any amino acid and Xaa.sub.5 is Trp or Tyr. When the peptide contains Xaa.sub.1, it is preferably Gly, Glu, or Lys, most preferably Gly. When Xaa.sub.3 is D- or L-Trp, Xaa.sub.2 is preferably Pro or 4-trans-hydroxyproline. When Xaa.sub.3 is D- or L-Leu, Xaa.sub.2 is preferably Val. The carboxy terminus may contain a carboxyl or an amide, preferably an amide. The present invention is further directed to the specific contryphan peptides and propeptides as described herein. The present invention is also directed to nucleic acids encoding the contryphan peptides and their propeptides as described herein. The contryphans of the present invention are useful as anticonvulsant or neuroprotective agents.

    摘要翻译： 本发明涉及具有6-12个氨基酸的优选肽，优选包括一个或多个D-色氨酸或D-亮氨酸残基。 本发明的肽通常被称为“contryphans”，尽管含有D-亮氨酸的对应物有时被称为leu-contryphans。 更具体地说，本发明涉及具有通式Xaa1-Cys-Xaa2-Xaa3-Xaa4-Pro-Xaa5-Cys（SEQ ID NO：1）的反式肽，其中Xaa1是任何氨基酸或des-Xaa1，Xaa2 是Pro，4-反式 - 羟基脯氨酸或Val，Xaa3是D-Trp，L-Trp，D-Leu或L-Leu，优选D-Trp或D-Leu，Xaa4是任何氨基酸，Xaa5是Trp或Tyr。 当肽含有Xaa1时，其优选为Gly，Glu或Lys，最优选为Gly。 当Xaa3为D-或L-Trp时，Xaa2优选为Pro或4-反式 - 羟脯氨酸。 当Xaa3为D-或L-Leu时，Xaa2优选为Val。 羧基末端可以含有羧基或酰胺，优选酰胺。 本发明进一步针对如本文所述的特异性抗原肽和前肽。 本发明还涉及编码本文所述的敌百虫肽及其前肽的核酸。 本发明的对策可用作抗惊厥药或神经保护剂。

    Contryphan peptides
    6.
    发明授权
    Contryphan peptides 失效
    对角han肽

    公开(公告)号：US6077934A

    公开(公告)日：2000-06-20

    申请号：US61026

    申请日：1998-04-16

    申请人： Richard Jacobsen ,  Elsie Jimenez ,  Lourdes J. Cruz ,  Baldomero M. Olivera ,  William R. Gray ,  Michelle Grilley ,  Maren Watkins ,  David R. Hillyard

    发明人： Richard Jacobsen ,  Elsie Jimenez ,  Lourdes J. Cruz ,  Baldomero M. Olivera ,  William R. Gray ,  Michelle Grilley ,  Maren Watkins ,  David R. Hillyard

    IPC分类号： A61K38/00 ,  C07K7/06 ,  C07K5/00

    CPC分类号： C07K7/06 ,  A61K38/00 ,  Y10S530/857

    摘要： The present invention is directed to contryphan peptides having 6-12 amino acids, preferably including one or more D-tryptophan or D-leucine residues. The peptides of the present invention are generically termed "contryphans," although the D-leucine containing contryphans are sometimes referred to as leu-contryphans. More specifically, the present invention is directed to contryphan peptides having the general formula Xaa.sub.1 -Cys-Xaa.sub.2 -Xaa.sub.3 -Xaa.sub.4 -Pro-Xaa.sub.5 -Cys (SEQ ID NO:1), wherein Xaa.sub.1, is any amino acid or des-Xaa.sub.1, Xaa.sub.2 is Pro, 4-trans-hydroxyproline or Val, Xaa.sub.3 is D-Trp, L-Trp, D-Leu or L-Leu, preferably D-Trp or D-Leu, Xaa.sub.4 is any amino acid and Xaa.sub.5 is Trp or Tyr. When the peptide contains Xaa.sub.1, it is preferably Gly, Glu, or Lys, most preferably Gly. When Xaa.sub.3 is D- or L-Trp, Xaa.sub.2 is preferably Pro or 4-trans-hydroxyproline. When Xaa.sub.3 is D- or L-Leu, Xaa.sub.2 is preferably Val. The carboxy terminus may contain a carboxyl or an amide, preferably an amide. The present invention is further directed to the specific contryphan peptides and propeptides as described herein. The present invention is also directed to nucleic acids encoding the contryphan peptides and their propeptides as described herein. The contryphans of the present invention are useful as anticonvulsant or neuroprotective agents.

    摘要翻译： 本发明涉及具有6-12个氨基酸的优选肽，优选包括一个或多个D-色氨酸或D-亮氨酸残基。 本发明的肽通常被称为“contryphans”，尽管含有D-亮氨酸的对应物有时被称为leu-contryphans。 更具体地，本发明涉及具有通式Xaa1-Cys-Xaa2-Xaa3-Xaa4-Pro-Xaa5-Cys（SEQ ID NO：1）的反式肽，其中Xaa1是任何氨基酸或des-Xaa1， Xaa2是Pro，4-反 - 羟脯氨酸或Val，Xaa3是D-Trp，L-Trp，D-Leu或L-Leu，优选D-Trp或D-Leu，Xaa4是任何氨基酸，Xaa5是Trp或Tyr 。 当肽含有Xaa1时，其优选为Gly，Glu或Lys，最优选为Gly。 当Xaa3为D-或L-Trp时，Xaa2优选为Pro或4-反式 - 羟脯氨酸。 当Xaa3为D-或L-Leu时，Xaa2优选为Val。 羧基末端可以含有羧基或酰胺，优选酰胺。 本发明进一步针对如本文所述的特异性抗原肽和前肽。 本发明还涉及编码本文所述的敌百虫肽及其前肽的核酸。 本发明的对策可用作抗惊厥药或神经保护剂。

    Alignment and support tool for building siding
    7.
    发明授权
    Alignment and support tool for building siding 失效
    用于建筑壁板的对准和支撑工具

    公开(公告)号：US4862669A

    公开(公告)日：1989-09-05

    申请号：US121631

    申请日：1987-11-16

    申请人： Richard Jacobsen

    发明人： Richard Jacobsen

    IPC分类号： E04F13/08 ,  E04F21/18

    CPC分类号： E04F13/0864 ,  E04F21/1855 ,  Y10S52/01

    摘要： An alignment and support tool for positioning siding boards to be secured to a building consisting of an elongated upright, a hook attached to the bottom of the upright for securing the tool by wedging underneath an attached siding board, and one or more siding supports extending from the upright toward the building.

    摘要翻译： 一种用于定位和支撑工具，用于将壁板固定到由细长的立柱组成的建筑物上，钩子附接到立柱的底部，用于通过楔入在附着的底板下方固定工具，以及一个或多个壁板支撑件， 直立到建筑物。

    Compositions and Method for Temporary Reduction of Nasal and Sinus Pain
    8.
    发明申请
    Compositions and Method for Temporary Reduction of Nasal and Sinus Pain 审中-公开
    临床减少鼻窦痛的组成和方法

    公开(公告)号：US20120029086A1

    公开(公告)日：2012-02-02

    申请号：US13280836

    申请日：2011-10-25

    申请人： Richard Jacobsen

    发明人： Richard Jacobsen

    IPC分类号： A61K31/164 ,  A61P11/00

    CPC分类号： A61K31/167 ,  A61K9/0043 ,  A61K31/245 ,  A61K45/06 ,  A61K2300/00

    摘要： Compositions and method that are expedient, safe, non-habit forming, and non-sedating for temporary reduction of nasal and sinus pain comprised of a local anesthetic or local anesthetics in a pharmaceutically acceptable carrier by instillation into the nasal cavity and sinuses by method of nasal spray.

    摘要翻译： 通过滴注入鼻腔和鼻窦的药物可接受的载体中局部麻醉剂或局部麻醉剂来暂时减轻鼻窦疼痛的临时减轻的方法，安全，非习惯形成和非镇静的组合物和方法， 鼻喷雾。