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公开(公告)号:US06630573B1
公开(公告)日:2003-10-07
申请号:US09497491
申请日:2000-02-04
申请人: Craig Walker , Reshma Shetty , Baldomero M. Olivera , David Hooper , Richard Jacobsen , Doug Steele , Robert Jones
发明人: Craig Walker , Reshma Shetty , Baldomero M. Olivera , David Hooper , Richard Jacobsen , Doug Steele , Robert Jones
IPC分类号: A61K3808
CPC分类号: C07K14/43504 , A61K38/00
摘要: The invention relates to relatively short peptides (termed &tgr;-conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.
摘要翻译: 本发明涉及相对较短的肽(本文中称为tau-芋螺毒素),长度约10-25个残基,其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽,并且优选包括两个 二硫键。
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公开(公告)号:US07390785B2
公开(公告)日:2008-06-24
申请号:US11267257
申请日:2005-11-07
申请人: Craig Walker , Reshma Shetty , Baldomero M. Olivera , David Hooper , Richard Jacobsen , Doug Steel , Robert Jones
发明人: Craig Walker , Reshma Shetty , Baldomero M. Olivera , David Hooper , Richard Jacobsen , Doug Steel , Robert Jones
CPC分类号: C07K14/43504 , A61K38/00
摘要: The invention relates to relatively short peptides (termed τ-conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.
摘要翻译: 本发明涉及相对较短的肽(本文中称为tau-芋螺毒素),长度约10-25个残基,其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽,并且优选包括两个 二硫键。
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公开(公告)号:US20070173457A1
公开(公告)日:2007-07-26
申请号:US11267257
申请日:2005-11-07
申请人: Craig Walker , Reshma Shetty , Baldomero Olivera , David Hooper , Richard Jacobsen , Doug Steel , Robert Jones
发明人: Craig Walker , Reshma Shetty , Baldomero Olivera , David Hooper , Richard Jacobsen , Doug Steel , Robert Jones
CPC分类号: C07K14/43504 , A61K38/00
摘要: The invention relates to relatively short peptides (termed τ-conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.
摘要翻译: 本发明涉及相对较短的肽(本文中称为tau-芋螺毒素),长度约10-25个残基,其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽,并且优选包括两个 二硫键。
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公开(公告)号:US20050124547A1
公开(公告)日:2005-06-09
申请号:US10619473
申请日:2003-07-16
申请人: Craig Walker , Reshma Shetty , Baldomero Olivera , David Hooper , Richard Jacobsen , Doug Steel , Robert Jones
发明人: Craig Walker , Reshma Shetty , Baldomero Olivera , David Hooper , Richard Jacobsen , Doug Steel , Robert Jones
IPC分类号: C12N15/09 , A61K38/00 , A61P25/00 , A61P25/04 , A61P25/06 , A61P29/00 , A61P43/00 , C07K7/06 , C07K7/08 , C07K14/435 , C12N15/12 , A61K38/08 , A61K38/14
CPC分类号: C07K14/43504 , A61K38/00
摘要: The invention relates to relatively short peptides (termed τ-conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.
摘要翻译: 本发明涉及相对较短的肽(本文中称为tau-芋螺毒素),长度约10-25个残基,其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽,并且优选包括两个 二硫键。
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公开(公告)号:US20050214213A1
公开(公告)日:2005-09-29
申请号:US11097315
申请日:2005-04-04
申请人: Baldomero Olivera , J. McIntosh , Maren Watkins , James Garrett , Lourdes Cruz , Michelle Grilley , Robert Schoenfeld , Craig Walker , Reshma Shetty , Robert Jones
发明人: Baldomero Olivera , J. McIntosh , Maren Watkins , James Garrett , Lourdes Cruz , Michelle Grilley , Robert Schoenfeld , Craig Walker , Reshma Shetty , Robert Jones
IPC分类号: A61K38/00 , C07K14/435 , C12N5/02 , A61K51/00 , A61K38/16
CPC分类号: C07K14/43504 , A61K38/00
摘要: The present invention is directed to conotoxin peptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated ion channels, voltage-gated ligand channels and/or receptors. The invention is further directed to nucleic acid sequences encoding the conotoxin peptides and encoding propeptides, as well as the propeptides.
摘要翻译: 本发明涉及芋螺毒素肽,其衍生物或药学上可接受的盐。 本发明进一步涉及该肽,其衍生物和其药学上可接受的盐在治疗与电压门控离子通道,电压门控配体通道和/或受体相关的病症中的用途。 本发明还涉及编码芋螺毒素肽和编码前肽以及前肽的核酸序列。
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公开(公告)号:US20050096270A1
公开(公告)日:2005-05-05
申请号:US10894314
申请日:2004-07-20
申请人: Craig Walker , Reshma Shetty , Elsie Jimenez , J. McIntosh , Baldomero Olivera , Maren Watkins , Robert Jones , Gregory Shen
发明人: Craig Walker , Reshma Shetty , Elsie Jimenez , J. McIntosh , Baldomero Olivera , Maren Watkins , Robert Jones , Gregory Shen
IPC分类号: C07K14/435 , A61K38/16
CPC分类号: C07K14/43504
摘要: The invention relates to relatively short peptides (termed 1-conotoxins herein), about 30-50 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include four disulfide bonds.
摘要翻译: 本发明涉及相对短的肽(本文中称为1-芋螺毒素),长度约30-50个残基,其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽,并且优选包括四个 二硫键。
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公开(公告)号:US20060205656A1
公开(公告)日:2006-09-14
申请号:US11389172
申请日:2006-03-27
申请人: David Hooper , James Garrett , Gloria Corpuz , Lourdes Cruz , Baldomero Olivera , J. McIntosh , Robert Jones
发明人: David Hooper , James Garrett , Gloria Corpuz , Lourdes Cruz , Baldomero Olivera , J. McIntosh , Robert Jones
IPC分类号: A61K38/16 , C07K14/435
CPC分类号: A61K49/0004 , A61K38/00 , C07K14/43504
摘要: The present invention is directed to P-superfamily conopeptides, to DNA encoding precursors of the P-superfamily conopeptides and to the precursor peptides.
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公开(公告)号:US20060172948A1
公开(公告)日:2006-08-03
申请号:US11385997
申请日:2006-03-22
申请人: Baldomero Olivera , J. McIntosh , James Garrett , Craig Walker , Maren Watkins , Robert Jones
发明人: Baldomero Olivera , J. McIntosh , James Garrett , Craig Walker , Maren Watkins , Robert Jones
IPC分类号: A61K38/10 , C07K7/08 , C07K14/435
CPC分类号: C07K7/08 , A61K38/00 , C07K7/02 , C07K14/43504
摘要: The invention relates to γ-carboxyglutamate containing conopeptides, derivatives or pharmaceutically acceptable salts thereof, and uses thereof, including the treatment of neurologic and psychiatric disorders, such as anticonvulsant agents, as neuroprotective agents or for the management of pain. The invention further relates to nucleic acid sequences encoding the conopeptides and encoding propeptides, as well as the propeptides.
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公开(公告)号:US20050159586A1
公开(公告)日:2005-07-21
申请号:US11018369
申请日:2004-12-22
申请人: Baldomero Olivera , J. McIntosh , James Garrett , Craig Walker , Maren Watkins , Robert Jones
发明人: Baldomero Olivera , J. McIntosh , James Garrett , Craig Walker , Maren Watkins , Robert Jones
IPC分类号: A61K38/00 , A61P25/18 , A61P25/24 , A61P25/28 , C07K14/435
CPC分类号: C07K14/43504 , A61K38/00
摘要: The invention relates to linear γ-carboxyglutamate rich conotoxins, derivatives or pharmaceutically acceptable salts thereof, and uses thereof, including the treatment of neurologic and psychiatric disorders, such as anticonvillsant agents, as neuroprotective agents or for the management of pain. The invention further relates to nucleic acid sequences encoding the conopeptides and encoding propeptides, as well as the propeptides.
摘要翻译: 本发明涉及富含线性的γ-羧基谷氨酸富含芋螺毒素,其衍生物或其药学上可接受的盐及其用途,包括治疗神经系统疾病和精神病学疾病如抗惊厥药,作为神经保护剂或用于治疗疼痛。 本发明还涉及编码肽和编码前肽以及前肽的核酸序列。
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公开(公告)号:US20060241046A1
公开(公告)日:2006-10-26
申请号:US11476638
申请日:2006-06-29
申请人: Baldomero Olivera , J. McIntosh , James Garrett , Craig Walker , Maren Watkins , Robert Jones
发明人: Baldomero Olivera , J. McIntosh , James Garrett , Craig Walker , Maren Watkins , Robert Jones
IPC分类号: A61K38/16 , A61K38/10 , C07K14/435
CPC分类号: C07K14/43504 , A61K38/00
摘要: The invention relates to linear y-carboxyglutamate rich conotoxins, derivatives or pharmaceutically acceptable salts thereof, and uses thereof, including the treatment of neurologic and psychiatric disorders, such as anticonvulsant agents, as neuroprotective agents or for the management of pain. The invention further relates to nucleic acid sequences encoding the conopeptides and encoding propeptides, as well as the propeptides.
摘要翻译: 本发明涉及线性γ-羧基谷氨酸富含芋螺毒素,其衍生物或药学上可接受的盐及其用途,包括治疗神经和精神疾病,如抗惊厥剂,神经保护剂或用于治疗疼痛。 本发明还涉及编码肽和编码前肽以及前肽的核酸序列。
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