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公开(公告)号：US20240331809A1
公开(公告)日：2024-10-03
申请号：US18623197
申请日：2024-04-01
CPC分类号： G16C20/10 , G01N33/5055 , G16B20/50 , G16C20/70 , G01N2333/4716
摘要： Disclosed are methods, means and systems of identifying compounds and augment T regulatory cell activity and/or number in vitro and/or in vivo utilizing deep learning approaches. Systems for screening compound libraries in silico are provided as well as laboratory methods of testing modulation of T regulatory cell activity and/or numbers. Results provided by the disclosure will serve as the basis for increasing T regulatory cells, which is desirable in situations of autoimmunity or organ transplantation. In situations of oncology or infectious disease reduction of T regulatory cell number and/or activity is desired.
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公开(公告)号：US20230218671A1
公开(公告)日：2023-07-13
申请号：US18082841
申请日：2022-12-16
发明人： Thomas Ichim , Amit Patel , Timothy Warbington
摘要： Disclosed are novel method of inducing tissue regeneration through administration of gamma delta T cells that have been endowed regenerative activity. In one embodiment said regenerative active is bestowed upon said cells by culture with a regenerative cell population. In other embodiments a chimeric antigen receptor (CAR) is transfected which induces generation of regenerative substances upon activation of said CAR. Regenerative factors useful for the treatment of the invention depend on the condition for which treatment is desired, for example, in neurological conditions production of brain derived neurotrophic factor is produced upon activation of said CAR, wherein said CAR recognizes antigens or neoantigens associated with neuronal injury.
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公开(公告)号：US20230233614A1
公开(公告)日：2023-07-27
申请号：US18082907
申请日：2022-12-16
发明人： Thomas Ichim , Amit Patel , Timothy Warbington
IPC分类号： A61K35/28
CPC分类号： A61K35/28
摘要： The invention provides means, methods, and compositions of matter useful for treatment of viral induced sexual dysfunction. In one embodiment the invention teaches the use of autologous bone marrow mononuclear cells as a source of endothelial repair in penile or clitoral tissues that has been damaged by viral causes. In one embodiment, said viral cause is COVID-19 infection. In some embodiments the invention discloses means of maintaining and/or increasing sexual function, in some cases the invention describes preservation of tissue mass and/or size by administration of regenerative cells. Said cells may be autologous, allogeneic or xenogeneic. In some embodiments the invention teaches the utilization of derivatives of regenerative cells such as exosomes and/or conditioned media.
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公开(公告)号：US20230220041A1
公开(公告)日：2023-07-13
申请号：US18082857
申请日：2022-12-16
发明人： Thomas Ichim , Amit Patel , Timothy Warbington
IPC分类号： C07K14/725 , C07K14/54 , C07K14/49 , C07K14/515 , C07K14/65 , C07K14/475 , C07K16/18 , A61K35/17
CPC分类号： C07K14/7051 , C07K14/5403 , C07K14/49 , C07K14/515 , C07K14/65 , C07K14/4753 , C07K16/18 , A61K35/17 , C07K2319/33 , C07K2319/02 , C07K2319/03 , A61K2039/5156
摘要： A method of creating antigen-specific, chimeric antigen receptor (CAR) T cells capable of secreting regenerative growth factors upon activation of said CAR. In one embodiment said regenerative CAR-T cells possess a CAR capable of selectively recognizing damaged tissue. In one embodiment said CAR recognizes damage-associated molecular patterns (DAMPs) such as ATP, HMGB-1, matricryptins, cold-inducible RNA-binding protein, histones and mitochondrial DNA. Upon activation of said CAR said regenerative CAR-T cell is induced to produce one or more regenerative growth factors. In some embodiments the invention provides a suicide gene in said regenerative CAR-T cells in order to remove said cells after their therapeutic purpose is completed.
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5.发明公开公开(公告)号：US20240339176A1
公开(公告)日：2024-10-10
申请号：US18630510
申请日：2024-04-09
摘要： Disclosed are systems, means and compositions of matter utilizing artificial intelligence to create unique cells and/or organs from pluripotent stem cells. In one embodiment an artificial intelligence/machine learning approach is utilized to overview and categorize molecular and cellular data regarding normal embryonic development and associated pathways. Through acquiring this information, said artificial intelligence/machine learning system develops a graded list of morphogens/differentiating agents and/or conditions that are utilized to replicate the process of cell/tissue/organ formation artificially. In one embodiment the invention teaches generation of artificial pancreatic organoids through growth factors predicted by said artificial intelligence/machine learning systems. In other embodiments embryogenesis is recapitulated in adult tissue using predicted morphogens and/or extracellular matrix treatments.
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公开(公告)号：US20220202861A1
公开(公告)日：2022-06-30
申请号：US17559985
申请日：2021-12-22
发明人： Thomas Ichim , Amit Patel , Timothy Warbington
IPC分类号： A61K35/17 , A61P1/16 , C12N5/0735
摘要： Disclosed are methods, means and compositions of matter useful for treatment of liver failure using ex vivo reprogrammed immune cells. In one embodiment, cells of the recipient (autologous) are cocultured with a regenerative cell population alone or in the presence of one or more adjuvants. Said adjuvants enhance transfer of regenerative activity from said mesenchymal stem cells to said immune cells. In one embodiment said ex vivo reprogrammed immune cells are capable of inducing death or inactivation of hepatic stellate cells. In other embodiments, said immune cells provide antifibrotic activity to induce suppression of liver cirrhosis. In other embodiments, said immune cells provide for growth factors to enhance hepatic regeneration.
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公开(公告)号：US20240352395A1
公开(公告)日：2024-10-24
申请号：US18636179
申请日：2024-04-15
摘要： Disclosed are means of generating organs or organoids utilizing three-dimensional bio-printing processes. In one embodiment said organ is a pancreas or pancreas-like organ useful for the treatment of diabetes, wherein said bioprinted pancreas possesses enhanced regenerative activity, in some embodiments comparable to the liver due to seeding with enhanced numbers of regenerative cells. In another embodiment pancreatic islets are created capable of being utilized as a substitute for naturally occurring islets. In other embodiments immune-evasive organs are created utilizing combination of cells which possess ability to evade immunity, thus allowing for tolerance induction without need for immune suppressive activity.
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