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公开(公告)号：US20230218671A1
公开(公告)日：2023-07-13
申请号：US18082841
申请日：2022-12-16
发明人： Thomas Ichim , Amit Patel , Timothy Warbington
摘要： Disclosed are novel method of inducing tissue regeneration through administration of gamma delta T cells that have been endowed regenerative activity. In one embodiment said regenerative active is bestowed upon said cells by culture with a regenerative cell population. In other embodiments a chimeric antigen receptor (CAR) is transfected which induces generation of regenerative substances upon activation of said CAR. Regenerative factors useful for the treatment of the invention depend on the condition for which treatment is desired, for example, in neurological conditions production of brain derived neurotrophic factor is produced upon activation of said CAR, wherein said CAR recognizes antigens or neoantigens associated with neuronal injury.
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公开(公告)号：US20230014637A1
公开(公告)日：2023-01-19
申请号：US17865881
申请日：2022-07-15
发明人： Thomas Ichim , Amit Patel
IPC分类号： C12N5/0775
摘要： Disclosed are novel cellular populations generated by explosion of monocytic cells to conditioned media of regenerative cells. In one embodiment said regenerative cells are umbilical cord endothelial cells and said cells are pre-activated to possess enhance ability to reprogram said monocytic lineage cells. In one embodiment monocyte lineage cells are collected from leukopaks by plastic adherence and subsequently cultured in a manner to generate cells similar to M2 cells. In one embodiment said monocytic cells are cultured in a manner to generate myeloid derived suppressor cells. In one embodiment cells are generated to reducing inflammatory conditions. In another embodiment cells are generated for treatment of degenerative conditions. In another embodiment cells are generated for treatment of fibrosis.
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3.发明申请公开(公告)号：US20180360882A1
公开(公告)日：2018-12-20
申请号：US16009982
申请日：2018-06-15
发明人： Thomas Ichim , Amit Patel
IPC分类号： A61K35/17 , C07K14/71 , C12N5/0783 , C07K14/435 , A61K35/28 , A61K9/00 , A61K38/19 , A61K38/45 , A61K38/22
摘要： Disclosed are method of enhancing perispinal perfusion in a patient suffering from reduced perfusion of the lower back through administration of T regulatory cells alone capable of stimulating angiogenesis directly or through enhancement of angiogenic activities of cellular therapies. Said cellular therapies possessing angiogenic activities include mesenchymal stem cells, hematopoietic stem cells and endothelial progenitor cells. In one embodiment of the invention, administration of T regulatory cells is performed that are expanded ex vivo. For certain embodiment of the invention T regulatory cells may be autologous or allogeneic.
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4.发明申请公开(公告)号：US20180071342A1
公开(公告)日：2018-03-15
申请号：US15702735
申请日：2017-09-12
发明人： Thomas Ichim , Amit Patel
IPC分类号： A61K35/50 , C12N5/073 , C12N5/0775
CPC分类号： A61K35/50 , C12N5/0605 , C12N5/0668 , C12N2510/00
摘要： Disclosed are means of inducing and accelerating neurological recovery subsequent to a stroke through administration of amniotic fluid derived stem cells. In one embodiment stem cells are isolated from amniotic fluid and expanded under conditions allowing for expression of SSEA3, SSEA4, Tra1-60, Tra1-81, Tra2-54, Oct-4 and CD105. Said cells are subsequently administered into a patient having undergone a stroke, so as to induce direct regeneration (through transdifferentiation and replacement of neural tissue), as well as indirect regeneration (through production of growth factors that augment endogenous regenerative mechanisms while inhibiting degenerative mechanisms). In some embodiments factors produced by said amniotic fluid stem cells may be utilized instead of cells themselves. Said factors may include proteins, peptides, conditioned media, exosomes, or microvesicles.
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公开(公告)号：US20170290887A1
公开(公告)日：2017-10-12
申请号：US15481249
申请日：2017-04-06
发明人： Thomas Ichim , Amit Patel
IPC分类号： A61K38/18
CPC分类号： A61K38/1866 , A61K35/15 , A61K35/17 , A61K35/28 , A61K35/545
摘要： Disclosed are compositions of matter, therapeutic means, and methods of use for the treatment of female sexual dysfunction associated with vasculogenic degeneration. In one embodiment the invention teaches the use of systemic, or localized platelet rich plasma for restoration of vasculogenic responsiveness to neural signals associated with sexual function in females
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公开(公告)号：US20240331809A1
公开(公告)日：2024-10-03
申请号：US18623197
申请日：2024-04-01
CPC分类号： G16C20/10 , G01N33/5055 , G16B20/50 , G16C20/70 , G01N2333/4716
摘要： Disclosed are methods, means and systems of identifying compounds and augment T regulatory cell activity and/or number in vitro and/or in vivo utilizing deep learning approaches. Systems for screening compound libraries in silico are provided as well as laboratory methods of testing modulation of T regulatory cell activity and/or numbers. Results provided by the disclosure will serve as the basis for increasing T regulatory cells, which is desirable in situations of autoimmunity or organ transplantation. In situations of oncology or infectious disease reduction of T regulatory cell number and/or activity is desired.
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公开(公告)号：US20220202860A1
公开(公告)日：2022-06-30
申请号：US17559970
申请日：2021-12-22
发明人： Thomas Ichim , Amit Patel
IPC分类号： A61K35/17 , C12N5/0783 , A61P9/04
摘要： Disclosed are methods, means and compositions of matter useful for treatment of heart failure, and/or post infarct pathological remodeling using ex vivo reprogrammed immune cells. In one embodiment, cells of the recipient (autologous) are cocultured with a regenerative cell population alone or in the presence of one or more adjuvants. Said adjuvants enhance transfer of regenerative activity from said mesenchymal stem cells to said immune cells. In one embodiment said ex vivo reprogrammed immune cells are capable of inducing death or inactivation of cardiac fibrotic cells. In other embodiments, said immune cells provide antifibrotic activity to induce suppression of cardiac fibrosis. In other embodiments, said immune cells provide for growth factors to enhance cardiac regeneration.
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公开(公告)号：US20180334664A1
公开(公告)日：2018-11-22
申请号：US15981726
申请日：2018-05-16
发明人： Thomas Ichim , Annette Marleau
IPC分类号： C12N13/00 , C12N5/077 , C12N5/0775 , A61K35/28 , A61P15/12
CPC分类号： C12N13/00 , A61K35/28 , A61P15/12 , C12N5/0653 , C12N5/0665 , C12N5/0669
摘要： Disclosed are methods, devices, and techniques useful for enhancing function of an organ or cellular graft through administration of light frequencies sufficient to enhance desired therapeutic activity. In one embodiment a bone marrow cellular population is treated with one or more wavelengths of low level laser irradiation at a sufficient energy to enhance engraftment, trophic, and regenerative activity in the corpus cavernosum. In another embodiment the recipient penile body is treated with one or more wavelengths of low level laser irradiation at a sufficient energy to enhance chemoattraction and growth factor secretion.
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9.发明申请公开(公告)号：US20180085405A1
公开(公告)日：2018-03-29
申请号：US15717810
申请日：2017-09-27
发明人： Thomas Ichim , Amit Patel , Santosh Kesari
IPC分类号： A61K35/50
CPC分类号： A61K35/50 , A61K35/545 , C12N2502/03
摘要： Disclosed are compositions of matter useful for treatment of stroke derived from amniotic fluid stem cell produced factors. In one embodiment the invention teaches the use of products derived from amniotic fluid stem cells cultured under basal conditions. In another embodiment the invention teaches the utilization of amniotic stem cell derived products from said amniotic stem cells cultured under conditions of stress. Said amniotic stem cell derived products include small molecules, proteins, peptides, conditioned media, microvesicles, including exosomes and apoptotic bodies. In one embodiment, the invention teaches administration of amniotic fluid stem cells that have been exposed to a stress condition.
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10.发明申请公开(公告)号：US20170354686A1
公开(公告)日：2017-12-14
申请号：US15617813
申请日：2017-06-08
发明人： Thomas Ichim , Amit Patel
IPC分类号： A61K35/28 , C12N5/0775
CPC分类号： A61K35/28 , A61K35/35 , C12N5/0667 , C12N2500/84 , G01N33/50
摘要： Disclosed are means of treating spontaneous abortion utilizing cellular populations derived from autologous adipose tissue. In one embodiment the invention teaches the collection of stromal vascular fraction from women attempting to conceive, isolation of anti-abortigenic cells from said stromal vascular fraction, storing said cells, and administering said cells in early pregnancy or when conception is desired.
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