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    NUCLEIC ACID MOLECULES AND USES THEREOF
    1.
    发明申请
    NUCLEIC ACID MOLECULES AND USES THEREOF 有权

    公开(公告)号：US20210401966A1

    公开(公告)日：2021-12-30

    申请号：US17469313

    申请日：2021-09-08

    Applicant: CureVac AG

    Inventor： Susanne RAUCH ,  Kim Ellen SCHWENDT ,  Benjamin PETSCH

    IPC: A61K39/125 ,  C07K14/005 ,  A61P31/12 ,  A61K9/00

    Abstract: The present invention is directed to an artificial nucleic acid and to polypeptides suitable for use in treatment or prophylaxis of an infection with Norovirus or a disorder related to such an infection. In particular, the present invention concerns a Norovirus vaccine. The present invention is directed to an artificial nucleic acid, polypeptides, compositions and vaccines comprising the artificial nucleic acid or the polypeptides. The invention further concerns a method of treating or preventing a disorder or a disease, first and second medical uses of the artificial nucleic acid, polypeptides, compositions and vaccines. Further, the invention is directed to a kit, particularly to a kit of parts, comprising the artificial nucleic acid, polypeptides, compositions and vaccines.

    RESPIRATORY SYNCYTIAL VIRUS (RSV) VACCINE
    2.
    发明申请
    RESPIRATORY SYNCYTIAL VIRUS (RSV) VACCINE 有权

    公开(公告)号：US20210261627A1

    公开(公告)日：2021-08-26

    申请号：US17316834

    申请日：2021-05-11

    Applicant: CureVac AG

    Inventor： Thomas KRAMPS ,  Margit SCHNEE ,  Daniel VOSS ,  Benjamin PETSCH

    IPC: C07K14/005 ,  A61K39/12 ,  A61K39/155 ,  C07K16/10 ,  C12N7/00

    Abstract: The present invention relates to an mRNA sequence, comprising a coding region, encoding at least one antigenic peptide or protein of RSV infections Respiratory syncytial virus (RSV) or a fragment, variant or derivative thereof. Additionally the present invention relates to a composition comprising a plurality of mRNA sequences comprising a coding region, encoding at least one antigenic peptide or protein of RSV infections Respiratory syncytial virus (RSV) or a fragment, variant or derivative thereof. Furthermore it also discloses the use of the mRNA sequence or the composition comprising a plurality of mRNA sequences for the preparation of a pharmaceutical composition, especially a vaccine, e.g. for use in the prophylaxis or treatment of RSV infections Respiratory syncytial virus (RSV) infections. The present invention further describes a method of treatment or prophylaxis of RSV infections using the mRNA sequence.

    ZIKA VIRUS VACCINE
    3.
    发明申请
    ZIKA VIRUS VACCINE 有权

    公开(公告)号：US20210205434A1

    公开(公告)日：2021-07-08

    申请号：US15999469

    申请日：2017-02-17

    Applicant: CureVac AG ,  Sanofi Pasteur SA

    Inventor： Benjamin PETSCH ,  Edith JASNY ,  Yves GIRERO-CHAMBAZ

    IPC: A61K39/12 ,  C07K14/005 ,  A61K39/385 ,  A61K47/64 ,  A61P31/14

    Abstract: The present invention is directed to an artificial nucleic acid and to polypeptides suitable for use in treatment or prophylaxis of an infection with Zika virus or a disorder related to such an infection. In particular, the present invention concerns a Zika virus vaccine. The present invention is directed to an artificial nucleic acid, polypeptides, compositions and vaccines comprising the artificial nucleic acid or the polypeptides. The invention further concerns a method of treating or preventing a disorder or a disease, first and second medical uses of the artificial nucleic acid, polypeptides, compositions and vaccines. Further, the invention is directed to a kit, particularly to a kit of parts, comprising the artificial nucleic acid, polypeptides, compositions and vaccines.

    LASSA VIRUS VACCINE
    4.
    发明申请
    LASSA VIRUS VACCINE 审中-公开

    公开(公告)号：US20190351044A1

    公开(公告)日：2019-11-21

    申请号：US16471544

    申请日：2017-12-22

    Applicant: CureVac AG

    Inventor： Edith JASNY ,  Benjamin PETSCH

    IPC: A61K39/12 ,  C07K14/005 ,  C12N7/00 ,  A61P31/14

    Abstract: The present invention provides mRNAs usable as vaccines against lassa virus (LASV) infections. Further, the invention relates to (pharmaceutical) compositions and vaccines comprising said mRNAs and their use for treatment or prophylaxis of a lassa virus infection. The present invention further features a kit comprising the mRNAs, (pharmaceutical) compositions or vaccines and a method for treatment or prophylaxis of lassa virus infections using said mRNAs, pharmaceutical) compositions or vaccines.

    NUCLEIC ACID BASED COMBINATION VACCINES
    7.
    发明申请
    NUCLEIC ACID BASED COMBINATION VACCINES 有权

    公开(公告)号：US20220211838A1

    公开(公告)日：2022-07-07

    申请号：US17665704

    申请日：2022-02-07

    Applicant: CureVac AG

    Inventor： Cornelia OOSTVOGELS ,  Benjamin PETSCH ,  Susanne RAUCH ,  Kim Ellen SCHWENDT

    IPC: A61K39/145 ,  A61K39/155 ,  C07K14/005 ,  C12N7/00

    Abstract: The present invention is inter alia directed to pharmaceutical compositions comprising at least one nucleic acid encoding at least one antigenic peptide or protein from a Coronavirus, preferably a pandemic Coronavirus, and at least one nucleic acid encoding at least one antigenic peptide or protein from a further virus, e.g. an Influenza virus or an RSV virus. Pharmaceutical compositions provided herein are suitable for use in treatment or prophylaxis of an infection with at least one Coronavirus and at least one further virus infection, and may therefore be comprised in a combination vaccine. The nucleic acid sequences of the pharmaceutical compositions and combination vaccines are preferably in association with a polymeric carrier, a polycationic protein or peptide, or a lipid nanoparticle (LNP). The invention is also directed to first and second and further medical uses of the pharmaceutical compositions and combination vaccines, and to methods of treating or preventing a Coronavirus infection and a further virus infection.

    VACCINATION WITH mRNA-CODED ANTIGENS
    10.
    发明申请
    VACCINATION WITH mRNA-CODED ANTIGENS 有权

    公开(公告)号：US20210023199A1

    公开(公告)日：2021-01-28

    申请号：US17067614

    申请日：2020-10-09

    Applicant: CureVac AG

    Inventor： Karl-Josef KALLEN ,  Thomas KRAMPS ,  Margit SCHNEE ,  Benjamin PETSCH ,  Lothar STITZ

    IPC: A61K39/145 ,  A61K39/12 ,  A61K39/00 ,  A61K45/06 ,  C12N7/00

    Abstract: The present invention relates to vaccines comprising at least one mRNA encoding at least one antigen for use in the treatment of a disease in an elderly patient preferably exhibiting an age of at least 50 years, more preferably of at least 55 years, 60 years, 65 years, 70 years, or older, wherein the treatment comprises vaccination of the patient and eliciting an immune response in said patient. The present invention is furthermore directed to kits and kits of parts comprising such a vaccine and/or its components and to methods applying such a vaccine or kit.

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