公开(公告)号：US20240100142A1

公开(公告)日：2024-03-28

申请号：US18315781

申请日：2023-05-11

Applicant: CureVac SE

Inventor： Tilmann ROOS ,  Martin KUNZE ,  Benyamin YAZDAN PANAH ,  Salih YILMAZ ,  Markus CONZELMANN

IPC: A61K39/12 ,  A61P21/00 ,  A61P31/00 ,  A61P39/00 ,  C07K14/005 ,  C12N15/10 ,  C12Q1/6844 ,  C40B40/02 ,  C40B40/08

CPC classification number: A61K39/12 ,  A61P21/00 ,  A61P31/00 ,  A61P39/00 ,  C07K14/005 ,  C12N15/1024 ,  C12Q1/6844 ,  C40B40/02 ,  C40B40/08 ,  A61K2039/53

Abstract: The invention relates to a method for producing a ribonucleic acid (RNA) molecule composition comprising n different RNA molecule species, the method comprising a step of RNA in vitro transcription of a mixture of m different deoxyribonucleic acid (DNA) molecule species in a single reaction vessel in parallel, i.e. simultaneously, and a step of obtaining the RNA molecule composition. Also provided is the RNA composition provided by the inventive method and a pharmaceutical composition comprising the same as well as a pharmaceutical container. Moreover, the invention provides the RNA composition and the pharmaceutical composition for use as medicament.