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公开(公告)号：US12102696B2
公开(公告)日：2024-10-01
申请号：US17467110
申请日：2021-09-03
申请人： Curium US LLC
发明人： David Pipes , Lauren Radford , Shaun Loveless , Allan Casciola
CPC分类号： A61K51/0472 , A61K51/083
摘要： The present disclosure relates to methods to create a robust procedure capable of supplying commercial quantities of a radioactive diagnostic agent indicated for use with positron emission tomography (PET) for localization of somatostatin receptor positive neuroendocrine tumors (NETs) in adult patients.
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公开(公告)号：US20240024519A1
公开(公告)日：2024-01-25
申请号：US18354581
申请日：2023-07-18
申请人： Curium US LLC
发明人： Amanda Donovan , Lauren Radford , Allan Casciola
CPC分类号： A61K51/088 , A61K51/121
摘要： The present disclosure provides radiopharmaceutical composition comprising copper-64 that performs as a targeted diagnostic PET-agent. The radiopharmaceutical composition disclosed herein has a short physical half-life of about 12.7 h.
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公开(公告)号：US20240350679A1
公开(公告)日：2024-10-24
申请号：US18756231
申请日：2024-06-27
申请人： Curium US LLC
发明人： David Pipes , Lauren Radford , Shaun Loveless , Allan Casciola
CPC分类号： A61K51/0472 , A61K51/083
摘要： The present disclosure relates to methods to create a robust procedure capable of supplying commercial quantities of a radioactive diagnostic agent indicated for use with positron emission tomography (PET) for localization of somatostatin receptor positive neuroendocrine tumors (NETs) in adult patients.
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公开(公告)号：US20240339235A1
公开(公告)日：2024-10-10
申请号：US18745896
申请日：2024-06-17
申请人： Curium US LLC
发明人： Brian Regna , Allan Casciola , Lauren Radford , Shaun Loveless , David Pipes , William Uhland , Craig Brunkhorst
CPC分类号： G21G1/001 , A61K51/0482 , C01G3/003 , G21G1/10 , G21G4/08 , G21G2001/0094
摘要： Compositions comprising high levels of high specific activity copper-64, and process for preparing said compositions. The compositions comprise from about 2 Ci to about 15 Ci of copper-64 and have specific activities up to about 3800 mCi copper-64 per microgram of copper. The processes for preparing said compositions comprise bombarding a nickel-64 target with a low energy, high current proton beam, and purifying the copper-64 from other metals by a process comprising ion exchange chromatography or a process comprising a combination of extraction chromatography and ion exchange chromatography.
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公开(公告)号：US20220080059A1
公开(公告)日：2022-03-17
申请号：US17467110
申请日：2021-09-03
申请人： Curium US LLC
发明人： David Pipes , Lauren Radford , Shaun Loveless , Allan Casciola
摘要： The present disclosure relates to methods to create a robust procedure capable of supplying commercial quantities of a radioactive diagnostic agent indicated for use with positron emission tomography (PET) for localization of somatostatin receptor positive neuroendocrine tumors (NETs) in adult patients.
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