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公开(公告)号：US20110223621A1
公开(公告)日：2011-09-15
申请号：US13048587
申请日：2011-03-15
申请人： Curtis Keith , Alexis Borisy , Grant Zimmermann , Edward Roydon Jost-Price , Palaniyandi Manivasakam , Nicole W. Hurst , Michael A. Foley
发明人： Curtis Keith , Alexis Borisy , Grant Zimmermann , Edward Roydon Jost-Price , Palaniyandi Manivasakam , Nicole W. Hurst , Michael A. Foley
IPC分类号： G01N33/566 , C12N5/078
CPC分类号： A61K45/06 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/675 , A61K2300/00
摘要： The invention features pharmaceutical compositions that include dipyridamole and a corticosteroid.
摘要翻译： 本发明的特征在于药物组合物，其包括双嘧达莫和皮质类固醇。
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公开(公告)号：US07915265B2
公开(公告)日：2011-03-29
申请号：US11354552
申请日：2006-02-15
申请人： Curtis Keith , Alexis Borisy , Grant Zimmermann , Edward Roydon Jost-Price , Palaniyandi Manivasakam , Nicole W. Hurst , Michael A. Foley
发明人： Curtis Keith , Alexis Borisy , Grant Zimmermann , Edward Roydon Jost-Price , Palaniyandi Manivasakam , Nicole W. Hurst , Michael A. Foley
IPC分类号： A61K31/517 , A61K31/56
CPC分类号： A61K45/06 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/675 , A61K2300/00
摘要： The invention features pharmaceutical compositions that include dipyridamole and a corticosteroid.
摘要翻译： 本发明的特征在于药物组合物，其包括双嘧达莫和皮质类固醇。
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3.发明申请公开(公告)号：US20120058979A1
公开(公告)日：2012-03-08
申请号：US13292669
申请日：2011-11-09
申请人： Curtis Keith , Alexis Borisy , Grant R. Zimmermann , Edward Roydon Jost-Price , Palaniyandi Manivasakam , Nicole Hurst , Michael A. Foley , Michael S. Slavonic , Brendan Smith , Benjamin A. Auspitz
发明人： Curtis Keith , Alexis Borisy , Grant R. Zimmermann , Edward Roydon Jost-Price , Palaniyandi Manivasakam , Nicole Hurst , Michael A. Foley , Michael S. Slavonic , Brendan Smith , Benjamin A. Auspitz
IPC分类号： A61K31/573 , A61P37/06 , A61K31/575 , A61K31/568 , A61K31/58 , A61K31/57
CPC分类号： A61K31/565 , A61K9/0073 , A61K9/209 , A61K31/519 , A61K38/13 , A61K45/06 , A61K2300/00
摘要： The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering to the patient a tetra-substituted pyrimidopyrimidine, either alone or in combination with one or more additional agents. The invention also features a composition containing a tetra-substituted pyrimidopyrimidine in combination with one or more additional agents.
摘要翻译： 本发明的特征在于一种通过向患者施用四取代的嘧啶并嘧啶，单独或与一种或多种另外的试剂组合来治疗诊断患有或有发展为免疫炎性疾病风险的患者的方法。 本发明还特征在于含有四取代的嘧啶并嘧啶与一种或多种另外的试剂组合的组合物。
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公开(公告)号：US08080553B2
公开(公告)日：2011-12-20
申请号：US11517593
申请日：2006-09-07
申请人： Curtis Keith , Alexis Borisy , Grant R. Zimmermann , Edward Roydon Jost-Price , Palaniyandi Manivasakam , Nicole Hurst , Michael A. Foley , Michael S. Slavonic , Brendan Smith , Benjamin A. Auspitz
发明人： Curtis Keith , Alexis Borisy , Grant R. Zimmermann , Edward Roydon Jost-Price , Palaniyandi Manivasakam , Nicole Hurst , Michael A. Foley , Michael S. Slavonic , Brendan Smith , Benjamin A. Auspitz
IPC分类号： A01N43/54 , A01N43/90 , A61K31/517 , A61K31/519 , C07D239/42 , C07D401/04
CPC分类号： A61K31/565 , A61K9/0073 , A61K9/209 , A61K31/519 , A61K38/13 , A61K45/06 , A61K2300/00
摘要： The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering to the patient a tetra-substituted pyrimidopyrimidine, either alone or in combination with one or more additional agents. The invention also features a composition containing a tetra-substituted pyrimidopyrimidine in combination with one or more additional agents.
摘要翻译： 本发明的特征在于一种通过向患者施用四取代的嘧啶并嘧啶，单独或与一种或多种另外的试剂组合来治疗诊断患有或有风险发展免疫炎性疾病的患者的方法。 本发明还特征在于含有四取代的嘧啶并嘧啶与一种或多种另外的试剂组合的组合物。
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公开(公告)号：US07253155B2
公开(公告)日：2007-08-07
申请号：US10264991
申请日：2002-10-04
申请人： Curtis Keith , Alexis Borisy , Grant Zimmerman , Edward Roydon Jost-Price , Palaniyandi Manivasakam , Nicole Hurst , Michael A. Foley
发明人： Curtis Keith , Alexis Borisy , Grant Zimmerman , Edward Roydon Jost-Price , Palaniyandi Manivasakam , Nicole Hurst , Michael A. Foley
IPC分类号： A61K31/56 , A61K31/517
CPC分类号： A61K45/06 , A61K31/519 , A61K31/56 , A61K31/573 , A61K31/675 , A61K2300/00
摘要： The invention features a method for treating a patient having an immunoinflammatory disorder, by administering to the patient (i) a tetra-substituted pyrimidopyrimidine, and (ii) a corticosteroid simultaneously or within 14 days of each other in amounts sufficient to reduce or inhibit immunoinflammation.
摘要翻译： 本发明的特征在于一种治疗具有免疫炎症病症的患者的方法，其通过给予患者（i）四取代的嘧啶并嘧啶，和（ii）皮质类固醇同时或彼此之间的14天内，其量足以减少或抑制免疫炎症 。
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6.发明授权Combinations of chlorpromazine and pentamidine for the treatment of neoplastic disorders 失效组合氯丙嗪和喷他脒治疗肿瘤性疾病公开(公告)号：US06569853B1
公开(公告)日：2003-05-27
申请号：US09706929
申请日：2000-11-06
IPC分类号： A61K3154
CPC分类号： A61K45/06 , A61K31/155 , A61K31/495 , A61K31/54 , A61K31/5415 , A61K31/135 , A61K2300/00
摘要： The invention features a method for treating a patient having a cancer or other neoplasm, by administering to the patient (i) chlorpromazine or a metabolite or analog thereof; and (ii) pentamidine or a metabolite or analog thereof simultaneously or within 14 days of each other in amounts sufficient to inhibit the growth of the neoplasm.
摘要翻译： 本发明的特征在于通过给予患者（i）氯丙嗪或其代谢物或类似物来治疗患有癌症或其他肿瘤的患者的方法; 和（ii）戊脒或其代谢物或类似物同时或彼此之间的14天内以足以抑制肿瘤生长的量。
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7.发明授权Combinations of drugs (e.g., a benzimidazole and pentamidine) for the treatment of neoplastic disorders 失效用于治疗肿瘤性疾病的药物（例如，苯并咪唑和戊脒）的组合公开(公告)号：US06693125B2
公开(公告)日：2004-02-17
申请号：US09768870
申请日：2001-01-24
IPC分类号： A61K31415
CPC分类号： A61K31/415 , A61K31/135 , A61K2300/00
摘要： The invention features a method for treating a patient having a cancer or other neoplasm, by administering to the patient (i) a benzimidazole or a metabolite or analog thereof; and (ii) pentamidine or a metabolite or analog thereof simultaneously or within 14 days of each other in amounts sufficient to inhibit the growth of the neoplasm.
摘要翻译： 本发明的特征在于通过给予患者（i）苯并咪唑或其代谢物或类似物来治疗患有癌症或其他肿瘤的患者的方法; 和（ii）戊脒或其代谢物或类似物同时或彼此之间的14天内以足以抑制肿瘤生长的量。
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公开(公告)号：US07148216B2
公开(公告)日：2006-12-12
申请号：US11024303
申请日：2004-12-28
IPC分类号： A61K31/54
CPC分类号： A61K45/06 , A61K31/155 , A61K31/495 , A61K31/54 , A61K31/5415 , A61K31/135 , A61K2300/00
摘要： The invention features a method for treating a patient having a cancer or other neoplasm by administering to the patient two compounds simultaneously or within 14 days of each other in amounts sufficient to treat the patient.
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公开(公告)号：US06846816B2
公开(公告)日：2005-01-25
申请号：US10347714
申请日：2003-01-21
IPC分类号： A61K9/72 , A61K31/155 , A61K31/54 , A61K31/5415 , A61K45/06 , A61P35/00 , A61P43/00
CPC分类号： A61K45/06 , A61K31/155 , A61K31/495 , A61K31/54 , A61K31/5415 , A61K31/135 , A61K2300/00
摘要： The invention features a method for treating a patient having a cancer or other neoplasm by administering to the patient two compounds simultaneously or within 14 days of each other in amounts sufficient to treat the patient.
摘要翻译： 本发明的特征在于一种用于治疗患有癌症或其他肿瘤的患者的方法，所述方法通过以足以治疗患者的量彼此同时或相互给药14天内向患者施用两种化合物。
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公开(公告)号：US20080269272A1
公开(公告)日：2008-10-30
申请号：US12171208
申请日：2008-07-10
申请人： Julian Adams , Alfredo C. Castro , Michael A. Foley , Somarajan Nair Janardanan Nair , Marta Nevalainen , James R. Porter , Martin R. Tremblay
发明人： Julian Adams , Alfredo C. Castro , Michael A. Foley , Somarajan Nair Janardanan Nair , Marta Nevalainen , James R. Porter , Martin R. Tremblay
IPC分类号： A61K31/438 , C12N5/02 , A61P35/04
CPC分类号： C07D491/04
摘要： The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.
摘要翻译： 本发明提供用于调节平滑依赖性途径激活的组合物和方法。 本发明提供环巴胺的类似物，其可用于抵消刺猬蛋白途径的不期望的活化的表型效应，例如由刺猬蛋白获得功能，Ptc功能丧失或平滑获得功能突变引起的表型效应。 本发明的化合物特别可用于治疗癌症。
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