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公开(公告)号：US20100168023A1
公开(公告)日：2010-07-01
申请号：US12647677
申请日：2009-12-28
IPC分类号： A61K38/16 , A61K8/64 , A61P25/14 , A61P25/00 , A61P27/02 , A61P19/02 , A61P13/06 , A61P11/02 , A61P17/10 , A61P21/02 , A61P17/00 , A61P5/00 , A61Q19/08
CPC分类号： A61Q19/08 , A61K8/64 , A61K2800/592 , A61K2800/91
摘要： This invention provides novel injectable compositions comprising botulinum toxin that may be administered to a subject for various therapeutic, aesthetic and/or cosmetic purposes. The injectable compositions contemplated by the invention exhibit one or more advantages over conventional botulinum toxin formulations, including reduced antigenicity, a reduced tendency to undergo unwanted localized diffusion following injection, increased duration of clinical efficacy or enhanced potency relative, faster onset of clinical efficacy, and/or improved stability.
摘要翻译： 本发明提供包含肉毒杆菌毒素的新型可注射组合物，其可以以各种治疗，美学和/或美容目的施用于受试者。 本发明预期的可注射组合物相对于常规的肉毒杆菌毒素制剂显示出一个或多个优点，包括降低的抗原性，注射后经历不想要的局部扩散的倾向降低，临床疗效持续时间增加或相对增强的效力，临床疗效的更快发作，以及 /或改进的稳定性。
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公开(公告)号：US08623811B2
公开(公告)日：2014-01-07
申请号：US12669705
申请日：2008-07-28
申请人： Hongran F. Stone , Jacob M. Waugh
发明人： Hongran F. Stone , Jacob M. Waugh
CPC分类号： A61K38/16 , A61K8/64 , A61K9/0014 , A61K9/0043 , A61K9/006 , A61K9/0063 , A61K38/04 , A61K38/17 , A61K47/10 , A61Q17/005 , C07K14/4723 , Y02A50/473
摘要： The present invention provides antimicrobial peptides that exhibit a broad range of antimicrobial activity to gram positive and gram negative bacteria, as well as fungi, mold, and virus. The antimicrobial peptide of the invention is a cationic peptide, and may contain an HIV-TAT or reverse HIV-TAT sequence, or derivative thereof. The present invention further provides antimicrobial compositions containing the cationic peptide. Such compositions are especially useful for topical application to the skin, hair, nail, vagina, urethra, ear, oral cavity, nasal passage, respiratory system, opthalmic region, and various mucosal regions. The compositions of the present invention improve the condition and/or appearance of the treated region, and are suited for long-term and/or routine use to, for example, prevent or prevent the recurrence of microbial infection. The present invention further provides kits for use in improving the condition or appearance of skin, nail, or treated area. These kits may facilitate ease of use, long-term storage, and/or efficacy of the compositions.
摘要翻译： 本发明提供了抗菌肽，其对革兰氏阳性和革兰氏阴性菌以及真菌，霉菌和病毒具有广泛的抗微生物活性。 本发明的抗微生物肽是阳离子肽，并且可以含有HIV-TAT或反向HIV-TAT序列或其衍生物。 本发明还提供含有阳离子肽的抗微生物组合物。 这些组合物特别适用于局部施用于皮肤，毛发，指甲，阴道，尿道，耳朵，口腔，鼻通道，呼吸系统，眼部区域和各种粘膜区域。 本发明的组合物改善了处理区域的状态和/或外观，并且适于长期和/或常规使用以例如防止或预防微生物感染的复发。 本发明还提供用于改善皮肤，指甲或治疗区域的状况或外观的试剂盒。 这些试剂盒可以促进组合物的易用性，长期储存和/或功效。
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