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1.发明申请METHODS FOR TREATING DRUG-RESISTANT HEPATITIS C VIRUS INFECTION WITH A 5,5-FUSED ARYLENE OR HETEROARYLENE HEPATITIS C VIRUS INHIBITOR 审中-公开用5,5-FUSY ARYLENE或异丙肾上腺素C病毒抑制剂治疗耐药性丙型肝炎病毒感染的方法公开(公告)号：US20120252721A1
公开(公告)日：2012-10-04
申请号：US13434503
申请日：2012-03-29
申请人： Cyril B. Dousson , David Dukhan , John P. Billelo , Christophe Claude Parsy , Claire Pierra , Francois-Rene Alexandre , Guillaume Brandt , Daniel Da Costa , Houcine Rahali , Jean-Laurent Paparin , Michel Derock , Thierry Convard , Dominique Surleraux
发明人： Cyril B. Dousson , David Dukhan , John P. Billelo , Christophe Claude Parsy , Claire Pierra , Francois-Rene Alexandre , Guillaume Brandt , Daniel Da Costa , Houcine Rahali , Jean-Laurent Paparin , Michel Derock , Thierry Convard , Dominique Surleraux
IPC分类号： A61K31/4178 , A61K31/5377 , A61P31/14 , A61K31/4184 , A61P1/16 , A61K38/05 , A61K31/429
CPC分类号： A61K31/424 , A61K31/381 , A61K31/407 , A61K31/4188 , A61K31/429
摘要： Provided herein are methods for treating or preventing drug-resistant hepatitis C virus infection in a subject, which comprises administering to the subject a 5,5-fused heteroarylene hepatitis C virus inhibitor compound, for example, of Formula I, IA, or IB.
摘要翻译： 本文提供了治疗或预防受试者中耐药性丙型肝炎病毒感染的方法，其包括向受试者施用例如式I，IA或IB的5,5-稠合亚麻丙基丙型肝炎病毒抑制剂化合物。
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2.发明申请5,5-FUSED ARYLENE OR HETEROARYLENE HEPATITIS C VIRUS INHIBITORS 有权5,5-FUSED ARYLENE或HETEROARYLENE HEPATITIS C VIRUS INHIBITORS公开(公告)号：US20110150827A1
公开(公告)日：2011-06-23
申请号：US12972254
申请日：2010-12-17
申请人： Cyril B. Dousson , David Dukhan , Christophe Claude Parsy , Claire Pierra , Francois-Rene Alexandre , Guillaume Brandt , Daniel Da Costa , Houcine Rahali , Jean-Laurent Paparin , Michel Derock , Thierry Convard , Dominique Surleraux
发明人： Cyril B. Dousson , David Dukhan , Christophe Claude Parsy , Claire Pierra , Francois-Rene Alexandre , Guillaume Brandt , Daniel Da Costa , Houcine Rahali , Jean-Laurent Paparin , Michel Derock , Thierry Convard , Dominique Surleraux
IPC分类号： A61K38/20 , C07D513/04 , C07D498/04 , C07D495/04 , C07D487/04 , C07D491/048 , A61K31/429 , A61K31/424 , A61K31/4178 , A61K31/5377 , A61K31/4025 , A61K31/433 , A61K38/21 , A61K31/7056 , A61K31/7088 , A61P31/14 , A61P1/16 , A61P31/12 , C12N7/06
CPC分类号： C07D513/04 , A61K31/4178 , A61K31/4184 , A61K31/429 , A61K31/5377 , A61K31/7056 , A61K38/05 , A61K38/20 , A61K38/21 , A61K38/212 , A61K38/215 , A61K38/217 , C07D487/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07K5/06165
摘要： Provided herein are 5,5-fused heteroarylene hepatitis C virus inhibitor compounds, for example, of Formula I, IA, or IB, pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host in need thereof.
摘要翻译： 本文提供的是5,5-稠合亚磺酰丙型肝炎病毒抑制剂化合物，例如式I，IA或IB，包含该化合物的药物组合物及其制备方法。 还提供了它们用于在有需要的宿主中治疗HCV感染的方法。
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公开(公告)号：US08362068B2
公开(公告)日：2013-01-29
申请号：US12972254
申请日：2010-12-17
申请人： Cyril B. Dousson , David Dukhan , Christophe Claude Parsy , Claire Pierra , Francois-Rene Alexandre , Guillaume Brandt , Daniel Da Costa , Houcine Rahali , Jean-Laurent Paparin , Michel Derock , Thierry Convard , Dominique Surleraux
发明人： Cyril B. Dousson , David Dukhan , Christophe Claude Parsy , Claire Pierra , Francois-Rene Alexandre , Guillaume Brandt , Daniel Da Costa , Houcine Rahali , Jean-Laurent Paparin , Michel Derock , Thierry Convard , Dominique Surleraux
IPC分类号： A61K31/4184 , A61K31/4178 , A61K31/4025 , A61K31/381 , C07D235/04 , C07D409/14 , C07D495/04
CPC分类号： C07D513/04 , A61K31/4178 , A61K31/4184 , A61K31/429 , A61K31/5377 , A61K31/7056 , A61K38/05 , A61K38/20 , A61K38/21 , A61K38/212 , A61K38/215 , A61K38/217 , C07D487/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07K5/06165
摘要： Provided herein are 5,5-fused heteroarylene hepatitis C virus inhibitor compounds, for example, of Formula I, IA, or IB, pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host in need thereof.
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公开(公告)号：US20170101431A1
公开(公告)日：2017-04-13
申请号：US15313646
申请日：2015-05-27
申请人： Cyril Dousson , David Dukhan , Christophe Claude Parsy , Francois-Rene Alexandre , Rachid Rahali , Jean-Laurent Paparin
发明人： Cyril Dousson , David Dukhan , Christophe Claude Parsy , Francois-Rene Alexandre , Rachid Rahali , Jean-Laurent Paparin
IPC分类号： C07H19/20 , A61K45/06 , A61K31/7068 , A61K9/00 , A61K31/7076 , C07H19/10
CPC分类号： C07H19/20 , A61K9/0053 , A61K31/7068 , A61K31/7076 , A61K45/06 , C07H19/067 , C07H19/10 , C07H19/167 , C07H19/213
摘要： Provided herein are compounds, compositions, and methods for the treatment of cancer, including leukemia. In one embodiment, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-cancer agents.
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公开(公告)号：US20190262365A1
公开(公告)日：2019-08-29
申请号：US16344233
申请日：2017-10-20
申请人： Jean-Laurent PAPARIN , Houcine RAHALI , Aurelien SALANSON , Daniel DA COSTA , David DUKHAN , Timothy J. HARTINGH , Izzat RAHEEM , John SCHREIER , Merck Sharp & Dohme Corp.
发明人： Jean-Laurent Paparin , Houcine Rahali , Aurélien Salanson , Daniel Da Costa , David Dukhan , Timothy J. Hartingh , Izzat Raheem , John Schreier
IPC分类号： A61K31/675 , C07F9/6561 , A61P31/18
摘要： Compounds of Formula (I): (Formula (I)) and their pharmaceutically acceptable salts are useful for the inhibition of HIV reverse transcriptase. The compounds may also be useful for the prophylaxis or treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antiviral agents, immunomodulators, antibiotics or vaccines.
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公开(公告)号：US08193372B2
公开(公告)日：2012-06-05
申请号：US12716278
申请日：2010-03-03
申请人： Cyril Dousson , Claire Pierra , Jean-Francois Griffon , Frederic Leroy , Jean-Laurent Paparin , David Dukhan , Dominique Surleraux
发明人： Cyril Dousson , Claire Pierra , Jean-Francois Griffon , Frederic Leroy , Jean-Laurent Paparin , David Dukhan , Dominique Surleraux
IPC分类号： C07D333/36 , C07D277/20 , C07F9/02 , A61K31/519 , A61K31/425 , A61K31/38
CPC分类号： C07F9/6561 , C07F9/655345 , C07F9/65586
摘要： Provided herein are phosphothiophene and phosphothiazole compounds, for example, of any of Formulae I, IA, IIA, IIIA, IVA, VA, VIA, VIIA, IB, IIB, IIIB, IVB, VB, VIB and VIIB disclosed herein, pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host infected with HCV.
摘要翻译： 本文提供的是磷酸噻吩和磷酸噻唑化合物，例如本文公开的式I，IA，IIA，IIIA，IVA，VA，VIA，VIIA，IB，IIB，IIIB，IVB，VB，VIB和VIIB中任一项的药物组合物， 化合物及其制备方法。 还提供了它们用于在感染HCV的宿主中治疗HCV感染的方法。
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公开(公告)号：US20100233123A1
公开(公告)日：2010-09-16
申请号：US12716278
申请日：2010-03-03
申请人： Cyril Dousson , Claire Pierra , Jean-Francois Griffon , Frederic Leroy , Jean-Laurent Paparin , David Dukhan , Dominique Surleraux
发明人： Cyril Dousson , Claire Pierra , Jean-Francois Griffon , Frederic Leroy , Jean-Laurent Paparin , David Dukhan , Dominique Surleraux
IPC分类号： A61K38/21 , C07F9/28 , C07F9/06 , A61K31/675 , A61K31/67
CPC分类号： C07F9/6561 , C07F9/655345 , C07F9/65586
摘要： Provided herein are phosphothiophene and phosphothiazole compounds, for example, of any of Formulae I, IA, IIA, IIIA, IVA, VA, VIA, VIIA, IB, IIB, IIIB, IVB, VB, VIIB and VIIB disclosed herein, pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host infected with HCV.
摘要翻译： 本文提供的是磷酸噻吩和磷酸噻唑化合物，例如本文公开的式I，IA，IIA，IIIA，IVA，VA，VIA，VIIA，IB，IIB，IIIB，IVB，VB，VIIB和VIIB中任一项的药物组合物， 化合物及其制备方法。 还提供了它们用于在感染HCV的宿主中治疗HCV感染的方法。
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公开(公告)号：US10815264B2
公开(公告)日：2020-10-27
申请号：US15576607
申请日：2016-05-25
申请人： IDENIX PHARMACEUTICALS LLC , SOUTHERN RESEARCH INSTITUTE , Cyril B. Dousson , David Dukhan , Jean-Laurent Paparin , Christophe C. Parsy
IPC分类号： C07D409/04 , C07H19/10 , C07H19/11 , A61P35/02
摘要： The present application relates to novel nucleoside derivatives of formula (I) as claimed in claim 1, pharmaceutical compositions comprising the compounds, processes of preparation thereof, and methods of use thereof for treating cancer.
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公开(公告)号：US07932240B2
公开(公告)日：2011-04-26
申请号：US12198895
申请日：2008-08-27
IPC分类号： A61K31/675 , C07D239/70
CPC分类号： C07F9/65848
摘要： Provided herein are phosphadiazine polymerase inhibitor, for example, of any of Formulas IV, IV′, I″, II″, or IVa, pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host in need thereof.
摘要翻译： 本文提供的是膦二嗪聚合酶抑制剂，例如任何式IV，IV'，I“，II”或IVa，包含该化合物的药物组合物及其制备方法。 还提供了它们用于在有需要的宿主中治疗HCV感染的方法。
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公开(公告)号：US20090081158A1
公开(公告)日：2009-03-26
申请号：US12198895
申请日：2008-08-27
IPC分类号： A61K31/675 , A61K38/20 , A61K38/21 , A61P31/12
CPC分类号： C07F9/65848
摘要： Provided herein are phosphadiazine polymerase inhibitor, for example, of any of Formulas IV, IV′, I″, II″, or IVa, pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of an HCV infection in a host in need thereof.
摘要翻译： 本文提供的是膦二嗪聚合酶抑制剂，例如任何式IV，IV'，I“，II”或IVa，包含该化合物的药物组合物及其制备方法。 还提供了它们用于在有需要的宿主中治疗HCV感染的方法。
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