公开(公告)号：US20220032271A1

公开(公告)日：2022-02-03

申请号：US17298968

申请日：2019-12-02

Applicant: CytoSorbents Corporation

Inventor： Tamaz GULIASHVILI ,  Maryann GRUDA ,  Thomas GOLOBISH ,  David JAMES ,  Karl-Gustav RUGGEBERG ,  Pamela O'SULLIVAN ,  Sarah PATTERSON

IPC: B01J20/32 ,  C07K16/06 ,  C07K1/22 ,  B01J20/28 ,  B01D15/38

Abstract: The invention concerns polymeric media based on modified natural polysaccharides for removing one or both of Anti-A Antibodies and Anti-B Antibodies from human blood or plasma, the media comprising one or both of (i) a polymeric solid support with a blood group A Antigen ligand attached to the solid support at a ligand loading between 1-5 mg/mL of solid support, and wherein the media is stable under physiological pH conditions, and (ii) a polymeric solid support with a blood group B Antigen ligand attached to the solid support at a ligand loading between 1-5 mg/mL of solid support, and wherein the media is stable under physiological pH conditions.