公开(公告)号：US20220032271A1

公开(公告)日：2022-02-03

申请号：US17298968

申请日：2019-12-02

Applicant: CytoSorbents Corporation

Inventor： Tamaz GULIASHVILI ,  Maryann GRUDA ,  Thomas GOLOBISH ,  David JAMES ,  Karl-Gustav RUGGEBERG ,  Pamela O'SULLIVAN ,  Sarah PATTERSON

IPC: B01J20/32 ,  C07K16/06 ,  C07K1/22 ,  B01J20/28 ,  B01D15/38

Abstract: The invention concerns polymeric media based on modified natural polysaccharides for removing one or both of Anti-A Antibodies and Anti-B Antibodies from human blood or plasma, the media comprising one or both of (i) a polymeric solid support with a blood group A Antigen ligand attached to the solid support at a ligand loading between 1-5 mg/mL of solid support, and wherein the media is stable under physiological pH conditions, and (ii) a polymeric solid support with a blood group B Antigen ligand attached to the solid support at a ligand loading between 1-5 mg/mL of solid support, and wherein the media is stable under physiological pH conditions.

公开(公告)号：US20190060545A1

公开(公告)日：2019-02-28

申请号：US16082376

申请日：2017-02-17

Applicant: CYTOSORBENTS CORPORATION

Inventor： Maryann GRUDA ,  Pamela O'SULLIVAN ,  Tamaz GULIASHVILI ,  Andrew SCHEIRER ,  Thomas GOLOBISH ,  Vincent CAPPONI ,  Phillip CHAN

IPC: A61M1/34 ,  A61M1/36 ,  B01J20/26 ,  B01J20/28

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer sorbent with a plurality of pores, said polymer designed to adsorb pathogen-associated molecular pattern molecules and damage-associated molecular pattern molecules. Also disclosed herein are methods for reducing contamination in a biological substance, or treating contamination in a subject, by one or more pathogen-associated molecular pattern molecules and damage-associated molecular pattern molecules, by contacting the biological substance with an effective amount of sorbent capable of sorbing the toxin.

公开(公告)号：US20210106743A1

公开(公告)日：2021-04-15

申请号：US16497982

申请日：2018-03-22

Applicant: CYTOSORBENTS CORPORATION

Inventor： Wei-Tai YOUNG ,  Tamaz GULIASHVILI ,  Andrew SCHEIRER ,  Josh VICHARE ,  Timothy KOVACS ,  Maryann GRUDA ,  Thomas GOLOBISH ,  Vincent CAPPONI ,  Phillip CHAN

IPC: A61M1/34 ,  A61M1/36

Abstract: This invention discloses methods for reducing physiologic molecules in abnormal levels and/or exogenous toxins in blood from blood by way of an extracorporeal circuit comprising a hollow-fiber filter module and polymer sorbent in combination.

公开(公告)号：US20190201867A1

公开(公告)日：2019-07-04

申请号：US16303232

申请日：2017-05-18

Applicant: CYTOSORBENTS CORPORATION

Inventor： Tamaz GULIASHVILI ,  Thomas GOLOBISH ,  Maryann GRUDA ,  Pamela O'SULLIVAN ,  Andrew SCHEIRER ,  Vincent CAPPONI ,  Phillip CHAN ,  Wei-Tai YOUNG

IPC: B01J20/26 ,  B01D15/34 ,  A61M1/36 ,  B01J20/28 ,  B01J20/32 ,  A61K9/00 ,  A61K31/745

CPC classification number: B01J20/261 ,  A61K9/0031 ,  A61K9/0053 ,  A61K31/745 ,  A61M1/3679 ,  B01D15/125 ,  B01D15/34 ,  B01J20/262 ,  B01J20/267 ,  B01J20/28069 ,  B01J20/28078 ,  B01J20/2808 ,  B01J20/28083 ,  B01J20/28085 ,  B01J20/3208 ,  B01J20/3231 ,  B01J20/327 ,  B01J20/3272 ,  B01J20/3274 ,  B01J20/3289

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules. The inventions are in the field of porous polymeric sorbents, also in the field of broadly reducing endotoxins in blood and blood products that can cause endotoxemia, additionally, in the field of broadly removing endotoxins by perfusion or hemoperfusion.

公开(公告)号：US20180303870A1

公开(公告)日：2018-10-25

申请号：US15769361

申请日：2016-10-21

Applicant: CYTOSORBENTS CORPORATION

Inventor： Thomas GOLOBISH ,  Maryann GRUDA ,  Tamaz GULIASHVILI ,  Pamela O'SULLIVAN ,  Andrew SCHEIRER ,  Vi DAN ,  Wei-Tai YOUNG ,  Vincent CAPPONI ,  Phillip CHAN

IPC: A61K31/795 ,  A61K47/20 ,  A61K47/26 ,  A61M5/165

CPC classification number: A61K31/795 ,  A61K47/20 ,  A61K47/26 ,  A61M1/3679 ,  A61M5/14 ,  A61M5/165

Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.