公开(公告)号：US20240307515A1

公开(公告)日：2024-09-19

申请号：US18575949

申请日：2022-07-06

Applicant: Daicel Corporation

Inventor： Naoki SAKAGUCHI ,  Kunihiko YAMASHITA ,  Kazuhiro TERAI

IPC: A61K39/00 ,  A61K9/00 ,  A61M5/30

CPC classification number: A61K39/0011 ,  A61K9/0019 ,  A61M5/30 ,  A61K2039/53 ,  A61K2039/54

Abstract: Provided herein is a method of manufacturing a packaged vaccine personalized to a subject. Also provided is a method of administering a personalized vaccine to a subject. Further provided is an injector having an igniter and a removable cartridge.

公开(公告)号：US20240325659A1

公开(公告)日：2024-10-03

申请号：US18575953

申请日：2022-07-06

Applicant: Daicel Corporation

Inventor： Naoki SAKAGUCHI ,  Kunihiko YAMASHITA ,  Kazuhiro TERAI

IPC: A61M5/48 ,  A61K9/00 ,  A61K48/00 ,  A61M5/20 ,  A61M5/30 ,  C12N15/87

CPC classification number: A61M5/482 ,  A61K9/0019 ,  A61K48/0016 ,  A61M5/2046 ,  A61M5/30 ,  C12N15/87

Abstract: Provided herein is a method of administering a naked nucleic acid molecule to a subject. The method may include injecting the naked nucleic acid molecule to the subject, wherein the injecting exhibits a bi-phasic injection profile comprising a first phase and a second phase, the second phase being after the first phase, and the bi-phasic injection profile has (i) at least two peaks within 15 msec from the injecting, (ii) the first peak of at least 2 MPa, or (iii) the highest peak of the second phase of the bi-phasic injection within 30 msec from the injecting.

公开(公告)号：US20240058537A1

公开(公告)日：2024-02-22

申请号：US18270771

申请日：2021-12-28

Applicant: DAICEL CORPORATION

Inventor： Yuko SAKAGUCHI ,  Kazuhiro TERAI

IPC: A61M5/20

CPC classification number: A61M5/2053 ,  A61M5/2046

Abstract: An injector configured to inject a solution containing a biomolecule and a gas that is predetermined into an injection target without using an injection needle, the injector including a storage portion configured to store the solution containing the biomolecule and the gas, a nozzle portion communicating with the storage portion, the nozzle portion including an ejection port configured to eject the solution containing the biomolecule and the gas toward the injection target, and a pressurization portion configured to pressurize the solution containing the biomolecule and the gas that are stored in the storage portion during an operation and to eject the solution containing the biomolecule and the gas from the ejection port toward the injection target.

公开(公告)号：US20220387948A1

公开(公告)日：2022-12-08

申请号：US17755621

申请日：2020-11-04

Applicant: DAICEL CORPORATION

Inventor： Kazuhiro TERAI ,  Yuko SAKAGUCHI ,  Toru KITAGUCHI ,  Katsuya MIKI

IPC: B01F23/2373 ,  B01F23/237

Abstract: This application relates to an ultra fine bubble production apparatus for producing ultra fine bubbles. The apparatus may include a container portion including a liquid and a gas, and a drive portion for pressurization in the container portion. In the pressurization, the time required for the pressure to reach the maximum pressure from the start of the pressurization can be 2.0 milliseconds or less, and the maximum pressure can be 4.00 MPa or more.

公开(公告)号：US20220202846A1

公开(公告)日：2022-06-30

申请号：US17310002

申请日：2020-01-09

Applicant: OSAKA UNIVERSITY ,  DAICEL CORPORATION

Inventor： Tomoyuki NISHIKAWA ,  Yasufumi KANEDA ,  Kunihiko YAMASHITA ,  Ayano SUZUKI ,  Kazuhiro TERAI

IPC: A61K31/713 ,  C12N15/117 ,  A61P35/00

Abstract: An object of the present disclosure is at least to provide a technique for stimulating immunity in mammals, and the object is fulfilled by double-stranded RNA composed of: RNA composed of a base sequence represented by a sequence A below; and RNA composed of a base sequence represented by a sequence B below, each base of an (N)13-25 portion in the base sequence represented by the sequence A and the base sequence represented by the sequence B being or not being complementary bases, and all of the bases of (N)5-10 portions in the base sequence represented by the sequence A and the base sequence represented by the sequence B being complementary bases, and a Tm value of the (N)5-10 portion being 20° C. or higher: Sequence A: 5′-UUGUCAUAUGGACAAGUCCAAGACU(N)13-25(N)5-10-3′ (SEQ ID No: 1), and Sequence B: 5′-(N)5-10(N)13-25AGUCUUGGACUUGUCCAUAUGACAA-3′ (SEQ ID No: 2).

公开(公告)号：US20220017847A1

公开(公告)日：2022-01-20

申请号：US17311259

申请日：2019-11-29

Applicant: DAICEL CORPORATION

Inventor： Kazuhiro TERAI ,  Hiroshi MIYAZAKI ,  Toru KITAGUCHI ,  Yuko SAKAGUCHI ,  Katsuya MIKI

IPC: C12M3/06 ,  C12M1/26

Abstract: An object of the present disclosure is at least to provide a device that can easily introduce a substance into cells in vitro with high efficiency and in a short time, and the object is fulfilled by a device for introducing a substance into cells in vitro, the device comprising: an accommodation unit for accommodating a solution containing cells and a substance; and a driving unit for pressurization of the solution, wherein regarding the pressurization of the solution, time from when the pressurization starts until pressure reaches a maximum pressure is 2.0 msec or shorter.