公开(公告)号：US11860187B2

公开(公告)日：2024-01-02

申请号：US17280552

申请日：2020-09-07

申请人： DALIAN UNIVERSITY OF TECHNOLOGY

发明人： Wei Zhang ,  Weihao Sun ,  Chengwei Wu ,  Jianli Ma

IPC分类号： G01Q60/28 ,  G06F30/23 ,  G01N15/10 ,  G01Q60/24 ,  G01Q30/04 ,  G01Q60/36 ,  G06F119/14

CPC分类号： G01Q60/28 ,  G01N15/10 ,  G01Q30/04 ,  G01Q60/366 ,  G06F30/23 ,  G01Q60/24 ,  G06F2119/14

摘要： This invention belongs to the technical field of cell mechanics and provides a modified method to fit cell elastic modulus based on Sneddon model. The process of the conical atomic force microscope probe compressing into the cell was simulated by ABAQUS. The simulation results are compared with the Sneddon model to get the error caused by Sneddon model. The fitting errors of Sneddon model under different circumstances were obtained by using the method of function fitting, so as to realize the modification of Sneddon model to fit cell elastic modulus. As a modified method to fit cell elastic modulus based on Sneddon model, it can be used to measure the elastic modulus of cells more accurately. The design process is convenient and fast. The design method is easy to master, and the process of use is convenient and simple.