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公开(公告)号：US20160272579A1
公开(公告)日：2016-09-22
申请号：US15034276
申请日：2014-11-05
IPC分类号： C07C237/40 , A61K31/69 , C07D213/82 , A61K31/4406 , A61K31/167 , C07D239/42 , A61K31/505 , C07D241/24 , A61K31/4965 , A61K45/06 , C07D213/81
CPC分类号： C07C237/40 , A61K31/167 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/455 , A61K31/4965 , A61K31/505 , A61K31/69 , A61K38/05 , A61K45/06 , C07C237/42 , C07D213/81 , C07D213/82 , C07D239/42 , C07D241/24 , A61K2300/00
摘要： The present invention relates to compounds which inhibit histone deacetylase activity and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing these compounds. The present invention also relates to methods of treating and preventing hematological cell proliferative disorders, such as multiple myeloma, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
摘要翻译： 本发明涉及抑制组蛋白脱乙酰酶活性的化合物和合成这些化合物的方法。 本发明还涉及含有这些化合物的药物组合物。 本发明还涉及通过将这些化合物和药物组合物给予有需要的受试者来治疗和预防血液细胞增殖性疾病如多发性骨髓瘤的方法。
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公开(公告)号：USRE49240E1
公开(公告)日：2022-10-11
申请号：US16815755
申请日：2020-03-11
IPC分类号： C07C237/40 , A61K31/167 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/455 , A61K31/4965 , A61K31/505 , A61K31/69 , A61K38/05 , A61K45/06 , C07C237/42 , C07D213/81 , C07D213/82 , C07D239/42 , C07D241/24
摘要： The present invention relates to compounds which inhibit histone deacetylase activity and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing these compounds. The present invention also relates to methods of treating and preventing hematological cell proliferative disorders, such as multiple myeloma, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
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公开(公告)号：US09988343B2
公开(公告)日：2018-06-05
申请号：US15034276
申请日：2014-11-05
IPC分类号： A61K31/4406 , A61K31/167 , A61K31/69 , C07C237/40 , C07D213/82 , C07D241/24 , A61K38/05 , A61K45/06 , A61K31/4402 , A61K31/4409 , A61K31/455 , A61K31/4965 , A61K31/505 , C07D213/81 , C07D239/42 , C07C237/42
CPC分类号： C07C237/40 , A61K31/167 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/455 , A61K31/4965 , A61K31/505 , A61K31/69 , A61K38/05 , A61K45/06 , C07C237/42 , C07D213/81 , C07D213/82 , C07D239/42 , C07D241/24 , A61K2300/00
摘要： The present invention relates to compounds which inhibit histone deacetylase activity and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing these compounds. The present invention also relates to methods of treating and preventing hematological cell proliferative disorders, such as multiple myeloma, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
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公开(公告)号：US11596691B2
公开(公告)日：2023-03-07
申请号：US17091863
申请日：2020-11-06
IPC分类号： C07D333/20 , C07D409/14 , C07D491/16 , C07F5/02 , C07C259/06 , C07C245/08 , C07C259/10 , A61K41/00
摘要： This invention relates to photoswitchable inhibitors of histone deacetylases and methods of using the same.
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公开(公告)号：US20210162048A1
公开(公告)日：2021-06-03
申请号：US17091863
申请日：2020-11-06
IPC分类号： A61K41/00 , C07D333/20 , C07D409/14 , C07D491/16 , C07F5/02 , C07C259/06 , C07C245/08 , C07C259/10
摘要： This invention relates to photoswitchable inhibitors of histone deacetylases and methods of using the same.
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公开(公告)号：US20190070295A1
公开(公告)日：2019-03-07
申请号：US15968634
申请日：2018-05-01
IPC分类号： A61K41/00 , C07C259/10 , C07C245/08 , C07D333/20 , C07F5/02 , C07D491/16 , C07D409/14 , C07C259/06
摘要： This invention relates to photoswitchable inhibitors of histone deacetylases and methods of using the same.
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公开(公告)号：US09981038B2
公开(公告)日：2018-05-29
申请号：US14775340
申请日：2014-03-13
IPC分类号： C07C245/08 , C07C259/10 , C07C259/06 , C07D333/20 , C07D491/16 , C07D409/14 , C07F5/02 , A61K41/00
CPC分类号： A61K41/0028 , C07C245/08 , C07C259/06 , C07C259/10 , C07D333/20 , C07D409/14 , C07D491/16 , C07F5/022
摘要： This invention relates to photoswitchable inhibitors of histone deacetylases and methods of using the same. Provided herein are inhibitors of HDAC having photoswitchable modulators of protein function with short thermal relaxation kinetics. The compounds are diazo compounds including a substituted or unsubstituted aryl or heteroaryl ring, wherein at least one of the rings is substituted with one or more HDAC targeting elements.
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公开(公告)号：US10828367B2
公开(公告)日：2020-11-10
申请号：US15968634
申请日：2018-05-01
IPC分类号： A61K41/00 , C07D333/20 , C07D409/14 , C07D491/16 , C07F5/02 , C07C259/06 , C07C245/08 , C07C259/10
摘要： This invention relates to photoswitchable inhibitors of histone deacetylases and methods of using the same.
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公开(公告)号：US20160022817A1
公开(公告)日：2016-01-28
申请号：US14775340
申请日：2014-03-13
IPC分类号： A61K41/00 , C07C259/10 , C07C259/06
CPC分类号： A61K41/0028 , C07C245/08 , C07C259/06 , C07C259/10 , C07D333/20 , C07D409/14 , C07D491/16 , C07F5/022
摘要： This invention relates to photoswitchable inhibitors of histone deacetylases and methods of using the same. Provided herein are inhibitors of HDAC having photoswitchable modulators of protein function with short thermal relaxation kinetics. The compounds are diazo compounds including a substituted or unsubstituted aryl or heteroaryl ring, wherein at least one of the rings is substituted with one or more HDAC targeting elements.
摘要翻译： 本发明涉及组蛋白脱乙酰酶的可光开关抑制剂及其使用方法。 本文提供具有蛋白质功能的具有短热松弛动力学的可光开关调制器的HDAC抑制剂。 化合物是包括取代或未取代的芳基或杂芳基环的重氮化合物，其中至少一个环被一个或多个HDAC靶向元件取代。
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