公开(公告)号：US20240352499A1

公开(公告)日：2024-10-24

申请号：US18683749

申请日：2022-08-19

申请人： DANISCO US INC.

发明人： Cristina Bongiorni ,  Robert Pratt, II ,  Matt Reboli ,  Anita Van Kimmenade ,  Amanda Iverson

IPC分类号： C12P21/02 ,  C12N1/08 ,  C12N9/22 ,  C12N15/75 ,  C12R1/125

CPC分类号： C12P21/02 ,  C12N1/08 ,  C12N9/22 ,  C12N15/75 ,  C12R2001/125

摘要： The instant disclosure provides, among other things, novel nuclease proteins (enzymes), novel nuclease compositions and protein preparations thereof, recombinant polynucleotides (DNA) encoding such nuclease proteins, recombinant host cells expressing and producing one or more nuclease proteins (optionally co-expressing one or more proteins of interest) and the like. More particularly, the nuclease proteins (enzymes) of the instant disclosure are particularly useful in mitigating DNA contamination, such as contaminating DNA present in a fermentation broth in which microbial host cells have been fermented, contaminating DNA present in recovered proteins of interest, contaminating DNA present in protein preparations, and the like.