公开(公告)号：US10138300B2

公开(公告)日：2018-11-27

申请号：US15640935

申请日：2017-07-03

Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY

Inventor： Jiann-Shiun Lai ,  Li-Shuang Ai ,  Yan-Da Lai ,  Yen-Yu Wu ,  Yi-San Tsai ,  Yi-Jiue Tsai ,  Juo-Yu Huang ,  Cheng-Chou Yu ,  Chuan-Lung Hsu ,  Chien-Tsun Kuan ,  Szu-Liang Lai ,  Li-Ya Wang

IPC: C07K16/28 ,  C07K16/30 ,  G01N33/74 ,  A61K51/10 ,  A61K31/4439 ,  C07K14/71 ,  C07K16/00 ,  A61K47/68 ,  A61K47/48 ,  A61K39/00

Abstract: The present invention relates to an antibody or antigen-binding fragment thereof that bind human vascular endothelial growth factor receptor 2 (VEGFR-2). The present invention also relates to a method for inhibiting VEGFR-2-mediated signaling in a subject in need, a method for treating diseases and/or disorders caused by or related to VEGFR-2 activity and/or signaling in a subject afflicted with the diseases and disorders, a method for treating tumor in a subject afflicted with the tumor, a method for inhibiting cell proliferation of endothelial cells in a subject in need, and a method for detecting human vascular endothelial growth factor receptor in a sample.

公开(公告)号：US10752688B2

公开(公告)日：2020-08-25

申请号：US15859506

申请日：2017-12-30

Applicant: Development Center for Biotechnology

Inventor： Yu-Chen Yang ,  Li-Yu Chen ,  Chia-Hua Li ,  Pei-Han Tai ,  Hong-Kai Chen ,  Ying-Yung Lok ,  Chih-Yung Hu ,  Chien-Tsun Kuan ,  Chung-Hsiun Wu

IPC: C07K16/00 ,  C07K16/28 ,  A61P35/00 ,  G01N33/574 ,  A61K39/00

Abstract: An anti-human T-cell immunoglobulin domain and mucin domain 3 (TIM-3) antibody, can bind the peptides, comprising the amino-acid sequence RKGDVSL (SEQ ID NO: 9) and/or EKFNLKL (SEQ ID NO: 10) of human TIM-3 protein. The antibody can regulate immune cell activity. The antibody or binding fragment thereof is useful in diagnosis, prognosis, and treatment of cancers that have been reported to express cell-surface TIM-3 such as lung, liver, esophageal cancer and solid tumors.

公开(公告)号：US20180186884A1

公开(公告)日：2018-07-05

申请号：US15640935

申请日：2017-07-03

Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY

Inventor： JIANN-SHIUN LAI ,  Li-Shuang Ai ,  Yan-Da Lai ,  Yen-Yu Wu ,  Yi-San Tsai ,  Yi-Jiue Tsai ,  Juo-Yu Huang ,  Cheng-Chou Yu ,  Chuan-Lung Hsu ,  Chien-Tsun Kuan ,  Szu-Liang Lai ,  Li-Ya Wang

IPC: C07K16/28 ,  G01N33/74 ,  C07K16/30 ,  A61K51/10 ,  A61K31/4439

CPC classification number: C07K16/2863 ,  A61K31/4439 ,  A61K47/6803 ,  A61K47/6849 ,  A61K51/1027 ,  A61K51/1096 ,  A61K2039/505 ,  A61K2039/507 ,  C07K14/71 ,  C07K16/005 ,  C07K16/2818 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  G01N33/74 ,  G01N2333/71

Abstract: The present invention relates to an antibody or antigen-binding fragment thereof that bind human vascular endothelial growth factor receptor 2 (VEGFR-2). The present invention also relates to a method for inhibiting VEGFR-2-mediated signaling in a subject in need, a method for treating diseases and/or disorders caused by or related to VEGFR-2 activity and/or signaling in a subject afflicted with the diseases and disorders, a method for treating tumor in a subject afflicted with the tumor, a method for inhibiting cell proliferation of endothelial cells in a subject in need, and a method for detecting human vascular endothelial growth factor receptor in a sample.