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    SYSTEM AND METHODS FOR PROCESSING ANALYTE SENSOR DATA
    1.
    发明申请
    SYSTEM AND METHODS FOR PROCESSING ANALYTE SENSOR DATA 审中-公开

    公开(公告)号：US20130237786A1

    公开(公告)日：2013-09-12

    申请号：US13868766

    申请日：2013-04-23

    Applicant: DEXCOM, INC.

    Inventor： Paul V. Goode, JR. ,  James H. Brauker ,  Apurv Ullas Kamath ,  Victoria E. Carr-Brendel

    IPC: A61B5/1495

    CPC classification number: A61B5/1495 ,  A61B5/14532 ,  A61B5/14542 ,  A61B5/14865 ,  A61B2560/0223

    Abstract: Systems and methods for processing sensor analyte data, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. During initial calibration, the analyte sensor data is evaluated over a period of time to determine stability of the sensor. The sensor may be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. The calibration may be updated after evaluating the calibration set for best calibration based on inclusion criteria with newly received reference analyte data. Fail-safe mechanisms are provided based on clinical acceptability of reference and analyte data and quality of sensor calibration. Algorithms provide for optimized prospective and retrospective analysis of estimated blood analyte data from an analyte sensor.

    SIGNAL PROCESSING FOR CONTINUOUS ANALYTE SENSOR
    2.
    发明申请
    SIGNAL PROCESSING FOR CONTINUOUS ANALYTE SENSOR 审中-公开

    公开(公告)号：US20190380629A1

    公开(公告)日：2019-12-19

    申请号：US16554419

    申请日：2019-08-28

    Applicant: DexCom, Inc.

    Inventor： James H. Brauker ,  Victoria E. Carr-Brendel ,  Paul V. Goode, JR. ,  Apurv Ullas Kamath ,  James Patrick Thrower ,  Ben Xavier

    IPC: A61B5/145 ,  A61M5/172 ,  A61B5/1486 ,  A61B5/00 ,  A61B5/1495 ,  A61B5/1468

    Abstract: Systems and methods for dynamically and intelligently estimating analyte data from a continuous analyte sensor, including receiving a data stream, selecting one of a plurality of algorithms, and employing the selected algorithm to estimate analyte values. Additional data processing includes evaluating the selected estimative algorithms, analyzing a variation of the estimated analyte values based on statistical, clinical, or physiological parameters, comparing the estimated analyte values with corresponding measure analyte values, and providing output to a user. Estimation can be used to compensate for time lag, match sensor data with corresponding reference data, warn of upcoming clinical risk, replace erroneous sensor data signals, and provide more timely analyte information encourage proactive behavior and preempt clinical risk.

    SIGNAL PROCESSING FOR CONTINUOUS ANALYTE SENSOR
    4.
    发明申请
    SIGNAL PROCESSING FOR CONTINUOUS ANALYTE SENSOR 审中-公开
    连续分析传感器信号处理

    公开(公告)号：US20140180049A1

    公开(公告)日：2014-06-26

    申请号：US14189940

    申请日：2014-02-25

    Applicant: DexCom, Inc.

    Inventor： James H. Brauker ,  Victoria E. Carr-Brendel ,  Paul V. Goode ,  Apurv Ullas Kamath ,  James Patrick Thrower ,  Ben Xavier

    IPC: A61B5/145 ,  A61B5/00

    CPC classification number: A61B5/14532 ,  A61B5/145 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/7257 ,  A61B5/726 ,  A61B5/7264 ,  A61B5/7275 ,  A61B5/742 ,  A61B5/7455 ,  A61B5/746 ,  A61B5/7475 ,  A61M5/1723 ,  G06F19/00 ,  Y02A90/22 ,  Y02A90/26

    Abstract: Systems and methods for dynamically and intelligently estimating analyte data from a continuous analyte sensor, including receiving a data stream, selecting one of a plurality of algorithms, and employing the selected algorithm to estimate analyte values. Additional data processing includes evaluating the selected estimative algorithms, analyzing a variation of the estimated analyte values based on statistical, clinical, or physiological parameters, comparing the estimated analyte values with corresponding measure analyte values, and providing output to a user. Estimation can be used to compensate for time lag, match sensor data with corresponding reference data, warn of upcoming clinical risk, replace erroneous sensor data signals, and provide more timely analyte information encourage proactive behavior and preempt clinical risk.

    Abstract translation: 用于动态和智能地估计来自连续分析物传感器的分析物数据的系统和方法，包括接收数据流，选择多种算法中的一种，以及采用所选择的算法来估计分析物值。 附加数据处理包括评估所选择的估计算法，基于统计学，临床或生理参数分析估计分析物值的变化，将估计的分析物值与相应的测量分析物值进行比较，以及向用户提供输出。 估计可用于补偿时间滞后，匹配传感器数据与相应的参考数据，警告即将到来的临床风险，替换错误的传感器数据信号，并提供更及时的分析物信息，鼓励主动行为和抢占临床风险。

    ELECTRODE SYSTEMS FOR ELECTROCHEMICAL SENSORS
    7.
    发明申请
    ELECTRODE SYSTEMS FOR ELECTROCHEMICAL SENSORS 审中-公开
    电化学传感器电极系统

    公开(公告)号：US20140001042A1

    公开(公告)日：2014-01-02

    申请号：US14014216

    申请日：2013-08-29

    Applicant: DexCom, Inc.

    Inventor： Peter C. Simpson ,  James R. Petisce ,  Victoria E. Carr-Brendel ,  James H. Brauker

    IPC: G01N27/327

    CPC classification number: G01N27/3274 ,  A61B5/14532 ,  A61B5/14865 ,  C12Q1/001

    Abstract: The present invention relates generally to systems and methods for improved electrochemical measurement of analytes. The preferred embodiments employ electrode systems including an analyte-measuring electrode for measuring the analyte or the product of an enzyme reaction with the analyte and an auxiliary electrode configured to generate oxygen and/or reduce electrochemical interferants. Oxygen generation by the auxiliary electrode advantageously improves oxygen availability to the enzyme and/or counter electrode; thereby enabling the electrochemical sensors of the preferred embodiments to function even during ischemic conditions. Interferant modification by the auxiliary electrode advantageously renders them substantially non-reactive at the analyte-measuring electrode, thereby reducing or eliminating inaccuracies in the analyte signal due to electrochemical interferants.

    Abstract translation: 本发明一般涉及用于改进分析物的电化学测量的系统和方法。 优选实施例采用电极系统，包括用于测量被分析物的分析物测量电极或与分析物的酶反应的产物以及被配置为产生氧和/或减少电化学干扰剂的辅助电极。 通过辅助电极产生氧气有利地提高了对酶和/或对电极的氧气可利用性; 从而使得优选实施例的电化学传感器能够在缺血状况下起作用。 通过辅助电极的干扰修饰有利地使得它们在分析物 - 测量电极处基本上不反应，从而减少或消除由于电化学干扰剂引起的分析物信号的不准确性。

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