公开(公告)号：US11953478B2

公开(公告)日：2024-04-09

申请号：US17593349

申请日：2020-03-10

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Nic G. Bloomfield ,  Lyle Lorrence Burton ,  John Lawrence Campbell ,  David M. Cox ,  Eva Duchoslav ,  Adam San-Ho Lau

IPC: H01J49/00 ,  G01N30/72 ,  G01N30/86 ,  H01J49/04 ,  H01J49/16 ,  H01J49/42 ,  H01J49/44

CPC classification number: G01N30/8631 ,  G01N30/7206 ,  G01N30/7233 ,  H01J49/0031 ,  H01J49/0418 ,  H01J49/167 ,  H01J49/4225 ,  H01J49/446

Abstract: Each of one or more unknown compounds are separated from a sample over a separation time period. Separated compounds are ionized, producing one or more compound precursor ions for each of the unknown compounds and a plurality of background precursor ions. A precursor ion mass spectrum is measured for the combined compound and background precursor ions at each time step of a plurality of time steps spread across the separation time period, producing a plurality of precursor ion mass spectra. One or more background precursor ions are selected from the plurality of precursor ion mass spectra that have a resolving power in a range below a threshold expected resolving power. A separation time is detected for an unknown compound when a decrease in an intensity measurement of the selected background precursor ions over a time period exceeds a threshold decrease in intensity with respect to time.

公开(公告)号：US20220187260A1

公开(公告)日：2022-06-16

申请号：US17593349

申请日：2020-03-10

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Nic G. Bloomfield ,  Lyle Lorrence Burton ,  John Lawrence Campbell ,  David M. Cox ,  Eva Duchoslav ,  Adam San-Ho Lau

IPC: G01N30/86 ,  H01J49/16 ,  H01J49/00 ,  H01J49/04 ,  H01J49/42 ,  H01J49/44 ,  G01N30/72

Abstract: Each of one or more unknown compounds are separated from a sample over a separation time period. Separated compounds are ionized, producing one or more compound precursor ions for each of the unknown compounds and a plurality of background precursor ions. A precursor ion mass spectrum is measured for the combined compound and background precursor ions at each time step of a plurality of time steps spread across the separation time period, producing a plurality of precursor ion mass spectra. One or more background precursor ions are selected from the plurality of precursor ion mass spectra that have a resolving power in a range below a threshold expected resolving power. A separation time is detected for an unknown compound when a decrease in an intensity measurement of the selected background precursor ions over a time period exceeds a threshold decrease in intensity with respect to time.