公开(公告)号：US12080531B2

公开(公告)日：2024-09-03

申请号：US17756928

申请日：2020-09-29

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： James Hager

IPC: H01J49/00 ,  G06F17/14 ,  H01J49/06

CPC classification number: H01J49/0009 ,  G06F17/142 ,  H01J49/063

Abstract: In one aspect, a method of calibrating a Fourier Transform (FT) multipole mass spectrometer is disclosed, which comprises measuring a plurality of secular frequencies of a calibrant ion in a multipole FT mass analyzer for a plurality of RF voltages (VRF) applied to at least one rod of the multipole mass analyzer, calculating Mathieu β and q parameters for each of 5 the measured secular frequencies, and determining RF voltage amplitude (VRF) for each calculated q parameter. For each calculated q parameter, an offset RF voltage amplitude (ΔVRF) corresponding to a deviation of the applied VRF and the calculated VRF is determined so as to generate a ΔVRFv.s. q calibration curve.

公开(公告)号：US20210327700A1

公开(公告)日：2021-10-21

申请号：US17270485

申请日：2019-08-21

Applicant: DH Technologies Development Pte. Ltd.

Inventor： James Hager

IPC: H01J49/06 ,  H01J49/00 ,  H01J49/24 ,  H01J49/10

Abstract: Systems and methods described herein utilize a multipole ion guide that can receive ions from an ion source for transmission to downstream mass analyzers, while preventing unwanted/interfering/contaminating ions from being transmitted into the high-vacuum chambers of mass spectrometry systems. In various aspects, RF and/or DC signals can be provided to auxiliary electrodes interposed within a quadrupole rod set so as to control or manipulate the transmission of ions from the multipole ion guide.

公开(公告)号：US09997340B2

公开(公告)日：2018-06-12

申请号：US15021362

申请日：2014-09-12

Applicant: DH Technologies Development PTE Ltd.

Inventor： James Hager ,  Christopher M Lock

IPC: H01J49/42 ,  H01J49/00 ,  H01J49/06

CPC classification number: H01J49/0036 ,  H01J49/005 ,  H01J49/063 ,  H01J49/4215

Abstract: A mass spectrometer apparatus and method for conducting simultaneous MS/MS analysis including: a device to select a precursor ion having a specified m/z; a gas-filled collision cell; an RF-only multipole mass spectrometer, the mass spectrometer having a generator attached thereto for generating at least two auxiliary AC fields in the RF-only multipole mass spectrometer; a gate for providing a repulsive DC or AC barrier downstream to an exit of the RF-only multipole mass spectrometer; an ion detection system situated downstream from the DC or AC barrier for measuring an ion current derived from ions that overcome the repulsive barrier. The mass spectrometer may also be configured so that each of the auxiliary AC fields are generated by the introduction of individual auxiliary AC frequencies and each frequency is amplitude modulated at a unique frequency.

公开(公告)号：US12243737B2

公开(公告)日：2025-03-04

申请号：US17754968

申请日：2020-09-29

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： James Hager

IPC: H01J49/42

Abstract: In various aspects, methods and systems disclosed herein are capable of operating a Fourier Transform Mass Spectrometry (FTMS) quadrupole mass analyzer in two operational modes: transmitting mode and trapping mode. In the trapping mode, ions are first trapped and cooled within the FTMS quadrupole mass analyzer prior to being subjected to an excitation pulse and ejected from the FTMS quadrupole mass analyzer for detection. However, in transmitting mode, the FTMS quadrupole mass analyzer may provide more rapid analysis because the excitation pulse is applied to the ions of an ion beam that is being continuously transmitted through the FTMS quadrupole mass analyzer.

公开(公告)号：US11810771B2

公开(公告)日：2023-11-07

申请号：US16482476

申请日：2018-01-29

Applicant: DH Technologies Development Pte. Ltd.

Inventor： James Hager

IPC: H01J49/00 ,  H01J49/06 ,  H01J49/42

CPC classification number: H01J49/0031 ,  H01J49/063 ,  H01J49/067 ,  H01J49/427

Abstract: In one aspect, a mass analyzer is disclosed, which comprises a quadrupole having an input end for receiving ions and an output end through which ions can exit the quadrupole, said quadrupole having a plurality of rods to at least some of which an RF voltage can be applied for generating a quadrupolar field for causing radial confinement of the ions as they propagate through the quadrupole and further generating fringing fields in proximity of said output end. The mass analyzer further includes at least a voltage source for applying a voltage pulse to at least one of said rods so as to excite radial oscillations of at least a portion of the ions passing through the quadrupole at secular frequencies thereof, where the radially-excited ions interact with the fringing fields as they exit the quadrupole such that their radial oscillations are converted into axial oscillations.

公开(公告)号：US20230010966A1

公开(公告)日：2023-01-12

申请号：US17756928

申请日：2020-09-29

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： James Hager

IPC: H01J49/00 ,  G06F17/14 ,  H01J49/06

Abstract: In one aspect, a method of calibrating a Fourier Transform (FT) multipole mass spectrometer is disclosed, which comprises measuring a plurality of secular frequencies of a calibrant ion in a multipole FT mass analyzer for a plurality of RF voltages (VRF) applied to at least one rod of the multipole mass analyzer adjusted q analyzer, calculating Mathieu β and q parameters for each of 5 the measured secular frequencies, and determining RF voltage amplitude (VRF) for each calculated q parameter. For each calculated q parameter, an offset RF voltage amplitude (ΔVRF) corresponding to a deviation of the applied VRF and the calculated VRF is determined so as to generate a ΔVRFv.s. q calibration curve.

公开(公告)号：US11869758B2

公开(公告)日：2024-01-09

申请号：US17270493

申请日：2019-08-21

Applicant: DH Technologies Development Pte. Ltd.

Inventor： James Hager

IPC: H01J49/06 ,  H01J49/42

CPC classification number: H01J49/063 ,  H01J49/4225 ,  H01J49/4215

Abstract: Systems and methods disclosed herein utilize an interface positioned between an ion source and an ion guide of a mass spectrometry system that can be useful to control transmission ions from an ion source to a downstream mass analyzer. In various aspects, the present disclosure provides methods of modulating an introduction of ions into an ion guide. In some embodiments, the present disclosure provides methods of making and using disclosed interface elements and mass spectrometry systems. In some embodiments, implementations of the present disclosure are useful in mass spectrometry systems, including, for example, improving signal-to-noise and reducing contamination.

公开(公告)号：US20220384173A1

公开(公告)日：2022-12-01

申请号：US17754968

申请日：2020-09-29

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： James Hager

IPC: H01J49/42

Abstract: In various aspects, methods and systems disclosed herein are capable of operating a Fourier Transform Mass Spectrometry (FTMS) quadrupole mass analyzer in two operational modes: transmitting mode and trapping mode. In the trapping mode, ions are first trapped and cooled within the FTMS quadrupole mass analyzer prior to being subjected to an excitation pulse and ejected from the FTMS quadrupole mass analyzer for detection. However, in transmitting mode, the FTMS quadrupole mass analyzer may provide more rapid analysis because the excitation pulse is applied to the ions of an ion beam that is being continuously transmitted through the FTMS quadrupole mass analyzer.

公开(公告)号：US12230489B2

公开(公告)日：2025-02-18

申请号：US17792656

申请日：2021-01-14

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： James Hager

IPC: H01J49/00 ,  H01J49/06

Abstract: In one aspect, a mass spectrometer is disclosed, which comprises a Fourier Transform (FT) mass analyzer having an input port for receiving ions and an exit port through which the ions exit the FT mass analyzer, a detector disposed downstream of said FT analyzer for detecting ions exiting the FT analyzer, and a multi-segment ion guide having a plurality of segments, said multi-segment ion guide being disposed upstream of said FT mass analyzer and having an input port for receiving ions and an output port through which ions exit the FT mass analyzer. The segments of the ion guide are configured to be independently activated via application of a DC offset voltage thereto so as to adjust a length through which ions passing through the ion guide experience collisional cooling.

公开(公告)号：US20230147220A1

公开(公告)日：2023-05-11

申请号：US17270493

申请日：2019-08-21

Applicant: DH Technologies Development Pte. Ltd.

Inventor： James Hager

IPC: H01J49/06 ,  H01J49/42

CPC classification number: H01J49/063 ,  H01J49/4225 ,  H01J49/4215

Abstract: Systems and methods disclosed herein utilize an interface positioned between an ion source and an ion guide of a mass spectrometry system that can be useful to control transmission ions from an ion source to a downstream mass analyzer. In various aspects, the present disclosure provides methods of modulating an introduction of ions into an ion guide. In some embodiments, the present disclosure provides methods of making and using disclosed interface elements and mass spectrometry systems. In some embodiments, implementations of the present disclosure are useful in mass spectrometry systems, including, for example, improving signal-to-noise and reducing contamination.