公开(公告)号：US09649278B2

公开(公告)日：2017-05-16

申请号：US14350535

申请日：2012-10-09

Applicant: Dow Global Technologies LLC

Inventor： Michael D. Read ,  Karen A. Coppens ,  Mark J. Hall ,  Jin Zhao

IPC: A61K9/48 ,  C08L1/28 ,  C08L5/00

CPC classification number: A61K9/4816 ,  A61K9/4833 ,  A61K9/4883 ,  C08K5/0016 ,  C08K5/05 ,  C08L1/28 ,  C08L1/286 ,  C08L5/00

Abstract: An injection-molded shell of a dosage form of good quality is producible by a) providing a composition comprising i) from 25 to 90 weight percent of ethylcellulose, ii) from 7.5 to 60 weight percent of a polysaccharide or polysaccharide derivative being different from ethylcellulose, and iii) from 2.5 to 50 weight percent of at least one component being different from polysaccharides and polysaccharide derivatives, based on the total weight of the composition, with the proviso that the composition comprises zero or not more than 10 weight percent of gelatin and zero or not more than 10 weight percent of a polymer comprising homo- or copolymerized acrylic acid, homo- or copolymerized methacrylic acid, a homo- or copolymerized acrylate or a homo- or copolymerized methacrylate, and b) subjecting the composition to shearing and heat to plasticize the composition and injection-molding the plasticized composition into a three-dimensional shell of a dosage form.

公开(公告)号：US20150072858A1

公开(公告)日：2015-03-12

申请号：US14540255

申请日：2014-11-13

Applicant: Dow Global Technologies LLC

Inventor： True L. Rogers ,  Debora L. Holbrook ,  Karen A. Coppens ,  Robert L. Schmitt

IPC: C09D101/28

CPC classification number: C09D101/284 ,  C08L1/26 ,  C08L1/284 ,  C09D101/26

Abstract: The present disclosure is directed to cellulose ether compositions for film-forming coating applications. A coating composition is provided which contains an aqueous solution of either a very low viscosity cellulose ether or a low-hydroxypropyl cellulose ether, the coating composition having low color. The low viscosity of the cellulose ether component enables the coating composition to contain a high concentration of cellulose ether. Provision of these high concentration cellulose ether coating solutions improves production efficiency by reducing the time required to coat a substrate.

Abstract translation: 本公开涉及用于成膜涂料应用的纤维素醚组合物。 提供一种包含非常低粘度的纤维素醚或低羟丙基纤维素醚的水溶液的涂料组合物，该涂料组合物具有低的颜色。 纤维素醚组分的低粘度使涂料组合物含有高浓度的纤维素醚。 提供这些高浓度纤维素醚涂层溶液通过减少涂布基材所需的时间来提高生产效率。

公开(公告)号：US20140271833A1

公开(公告)日：2014-09-18

申请号：US14350535

申请日：2012-10-09

Applicant: DOW GLOBAL TECHNOLOGIES LLC

Inventor： Michael D. Read ,  Karen A. Coppens ,  Mark J. Hall ,  Jin Zhao

IPC: A61K9/48

CPC classification number: A61K9/4816 ,  A61K9/4833 ,  A61K9/4883 ,  C08K5/0016 ,  C08K5/05 ,  C08L1/28 ,  C08L1/286 ,  C08L5/00

Abstract: An injection-molded shell of a dosage form of good quality is producible by a) providing a composition comprising i) from 25 to 90 weight percent of ethylcellulose, ii) from 7.5 to 60 weight percent of a polysaccharide or polysaccharide derivative being different from ethylcellulose, and iii) from 2.5 to 50 weight percent of at least one component being different from polysaccharides and polysaccharide derivatives, based on the total weight of the composition, with the proviso that the composition comprises zero or not more than 10 weight percent of gelatin and zero or not more than 10 weight percent of a polymer comprising homo- or copolymerized acrylic acid, homo- or copolymerized methacrylic acid, a homo- or copolymerized acrylate or a homo- or copolymerized methacrylate, and b) subjecting the composition to shearing and heat to plasticize the composition and injection-molding the plasticized composition into a three-dimensional shell of a dosage form.

Abstract translation: 具有良好质量的剂型的注射成型的外壳可以通过以下方式生产：a）提供组合物，其包含i）25至90重量％的乙基纤维素，ii）7.5至60重量％的不同于乙基纤维素的多糖或多糖衍生物 ，和iii）基于组合物的总重量，2.5至50重量％的至少一种与多糖和多糖衍生物不同的组分，条件是组合物包含零或不大于10重量％的明胶和 0或不超过10重量％的包含均聚或共聚的丙烯酸，均聚或共聚的甲基丙烯酸，均聚或共聚的丙烯酸酯或均聚或共聚的甲基丙烯酸酯的聚合物的聚合物，和b）使组合物经受剪切和加热 塑化组合物并将增塑组合物注塑成剂型的三维壳体。