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公开(公告)号：US11266612B2
公开(公告)日：2022-03-08
申请号：US16752119
申请日：2020-01-24
IPC分类号： A61K31/137 , A61K45/06 , A61K31/198 , A61K31/4045 , A61K31/428 , A61K31/473 , A61K31/48 , A61K31/506 , A61K31/519 , A61K31/5513 , A61K31/4184 , C07C211/29 , C07C215/08 , C07D209/14 , C07D471/04 , C07C215/54 , C07C217/62 , C07D235/16
摘要： The present invention provides a method of inhibiting, suppressing or preventing levodopa-induced dyskinesia in a patient suffering from Parkinson's Disease, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention. The present invention further provides a method of inhibiting, suppressing or preventing Parkinson's Disease in a patient, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention.
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公开(公告)号：US20220233475A1
公开(公告)日：2022-07-28
申请号：US17667323
申请日：2022-02-08
IPC分类号： A61K31/137 , A61K45/06 , A61K31/198 , A61K31/4045 , A61K31/428 , A61K31/473 , A61K31/48 , A61K31/506 , A61K31/519 , A61K31/5513 , A61K31/4184 , C07C211/29 , C07C215/08 , C07C215/54 , C07C217/62 , C07D209/14 , C07D235/16 , C07D471/04
摘要： The present invention provides a method of inhibiting, suppressing or preventing levodopa-induced dyskinesia in a patient suffering from Parkinson's Disease, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention. The present invention further provides a method of inhibiting, suppressing or preventing Parkinson's Disease in a patient, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention.
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公开(公告)号：US10543180B2
公开(公告)日：2020-01-28
申请号：US15497287
申请日：2017-04-26
IPC分类号： A61K31/137 , A61K45/06 , A61K31/198 , A61K31/4045 , A61K31/428 , A61K31/473 , A61K31/48 , A61K31/506 , A61K31/519 , A61K31/5513 , A61K31/4184 , C07C211/29 , C07C215/08 , C07C215/54 , C07C217/62 , C07D209/14 , C07D235/16 , C07D471/04
摘要： The present invention provides a method of inhibiting, suppressing or preventing levodopa-induced dyskinesia in a patient suffering from Parkinson's Disease, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention. The present invention further provides a method of inhibiting, suppressing or preventing Parkinson's Disease in a patient, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention.
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公开(公告)号：US09675565B2
公开(公告)日：2017-06-13
申请号：US13957861
申请日：2013-08-02
IPC分类号： C07C211/45 , C07C211/48 , A61K31/137 , A61K31/4045 , A61K31/4184 , A61K31/428 , A61K31/473 , A61K31/48 , A61K31/506 , A61K31/519 , C07C211/29 , C07C215/08 , C07C215/54 , C07C217/62 , C07D209/14 , C07D235/16 , C07D471/04 , A61K45/06 , A61K31/198 , A61K31/5513
CPC分类号： A61K31/137 , A61K31/198 , A61K31/4045 , A61K31/4184 , A61K31/428 , A61K31/473 , A61K31/48 , A61K31/506 , A61K31/519 , A61K31/5513 , A61K45/06 , C07C211/29 , C07C215/08 , C07C215/54 , C07C217/62 , C07D209/14 , C07D235/16 , C07D471/04 , A61K2300/00
摘要： The present invention provides a method of inhibiting, suppressing or preventing levodopa-induced dyskinesia in a patient suffering from Parkinson's Disease, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention. The present invention further provides a method of inhibiting, suppressing or preventing Parkinson's Disease in a patient, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention.
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公开(公告)号：US11724998B2
公开(公告)日：2023-08-15
申请号：US16478653
申请日：2018-01-18
IPC分类号： A61P1/00 , C07D401/06 , C07D209/12 , C07D471/04
CPC分类号： C07D401/06 , A61P1/00 , C07D209/12 , C07D471/04
摘要： Small molecule agonists of the pregnane X receptor (PXR), compositions and methods are disclosed for treating or preventing gut barrier dysfunction, an illness associated with gut barrier dysfunction, toxic or inflammatory injury to intestines, or leaky intestinal (gut) syndrome in a subject.
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6.发明授权公开(公告)号：US10428059B2
公开(公告)日：2019-10-01
申请号：US15726911
申请日：2017-10-06
申请人： DREXEL UNIVERSITY
IPC分类号： A61K31/519 , C07D417/14 , C07D309/32 , C07D215/54 , C07D317/58 , C07D317/66 , C07D401/04 , C07D249/08 , C07D471/04 , C07D487/04 , C07D491/052 , C07D493/04 , C07D513/04 , C07D211/90 , C07C317/44 , A61K45/06 , A61K31/4162 , A61K31/47 , A61K31/167 , A61K31/36 , A61K31/427 , A61K31/4439 , C07C237/52 , C07D263/56 , A61K38/00
摘要： The present invention provides compounds useful for treating or preventing an IL-1R-mediated disease or disorder. In certain embodiments, the disease or disorder comprises scleroderma.
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7.发明授权公开(公告)号：US10287290B2
公开(公告)日：2019-05-14
申请号：US15382002
申请日：2016-12-16
申请人： DREXEL UNIVERSITY
IPC分类号： C07D487/04 , A61K31/4439 , A61K31/53 , A61K31/341 , A61K31/381 , A61K31/4184 , A61K31/4196 , A61K31/42 , A61K31/425 , A61K31/4406 , A61K31/47 , A61K31/5365 , A61K45/06 , A61K31/427 , A61K31/4709 , C07D261/14 , C07D275/03 , C07D401/04 , C07D413/14 , C07D417/12 , A61K31/635
摘要： The present invention provides compounds useful for treating or preventing a brain-related disease or disorder. The present invention further provides a method of treating or preventing a brain-related disease or disorder in a patient, comprising administering to the patient a pharmaceutical composition comprising at least one compound of the invention. The present invention further provides a method of modulating the activity of a monoamine transporter.
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公开(公告)号：US20140228380A1
公开(公告)日：2014-08-14
申请号：US13957861
申请日：2013-08-02
申请人： University of Medicine and Dentistry New Jersey Medical School , Philadelphia Health & Education Corporation d/b/a Drexel University College of Medicine
IPC分类号： C07D471/04 , C07D235/16 , C07C211/29 , C07D209/14 , C07C215/08 , C07C215/54
CPC分类号： A61K31/137 , A61K31/198 , A61K31/4045 , A61K31/4184 , A61K31/428 , A61K31/473 , A61K31/48 , A61K31/506 , A61K31/519 , A61K31/5513 , A61K45/06 , C07C211/29 , C07C215/08 , C07C215/54 , C07C217/62 , C07D209/14 , C07D235/16 , C07D471/04 , A61K2300/00
摘要： The present invention provides a method of inhibiting, suppressing or preventing levodopa-induced dyskinesia in a patient suffering from Parkinson's Disease, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention. The present invention further provides a method of inhibiting, suppressing or preventing Parkinson's Disease in a patient, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention.
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公开(公告)号：US20240074993A1
公开(公告)日：2024-03-07
申请号：US18242036
申请日：2023-09-05
申请人： Drexel University
发明人： Sandhya Kortagere
IPC分类号： A61K31/137 , A61K31/4045 , A61K31/4184 , A61K31/519 , A61K45/06
CPC分类号： A61K31/137 , A61K31/4045 , A61K31/4184 , A61K31/519 , A61K45/06
摘要： The present invention provides a method of treating or preventing an attention and/or cognitive disorder in a subject in need thereof, comprising administering to the subject a compound useful within the invention. The present invention further provides a method of treating or preventing dementia associated with a neurodegenerative disorder in a subject in need thereof, comprising administering to the subject a compound useful within the invention.
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公开(公告)号：US20220402938A1
公开(公告)日：2022-12-22
申请号：US17847490
申请日：2022-06-23
申请人： Drexel University
IPC分类号： C07D495/04 , A61P25/28 , C07D401/14 , C07D403/04 , C07D405/14
摘要： The present invention provides compounds useful for treating, ameliorating or preventing a disease or disorder that is caused, induced or characterized by abnormal reduction in glutamate transporter activity or abnormal increase in extracellular CNS glutamate concentration in a subject. In certain embodiments, the compound stimulates a glutamate transporter.
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