公开(公告)号：US20220395613A1

公开(公告)日：2022-12-15

申请号：US17845141

申请日：2022-06-21

Applicant: DSM IP Assets B.V.

Inventor： Andrew FALLIS ,  Steven LEONHARDT ,  Justin KONTRA ,  Rakesh BATISH ,  Timothy RINGEISEN

IPC: A61L27/46 ,  A61L27/52 ,  A61L27/58

Abstract: The invention provides composite materials that form a biocompatible and bioresorbable settable ceramic-forming composition, and that possesses high strength when set and other desirable mechanical properties. The composite materials may include additive materials that provide beneficial advantages in the handling and physical properties of the material. When a hydrated precursor, the composite material is capable of being injected through cannulas for placement in treatment sites. The composite material provided desirable handling properties and sets in a clinically relevant time period.

公开(公告)号：US20210077123A1

公开(公告)日：2021-03-18

申请号：US16962464

申请日：2019-01-25

Applicant: DSM IP Assets B.V.

Inventor： William T. FISHER ,  Timothy RINGEISEN ,  Gino BRADICA

IPC: A61B17/16 ,  A61B17/04 ,  A61F2/28

Abstract: Disclosed are radially expanding debridement tools configured to pass through an access channel present in a first tissue of a living being, expand radially, and create a void in a second tissue of the living being upon being advanced distally through the access channel and into the second tissue while being rotated, wherein the shape of the void comprises at least one step. Further disclosed are debridement systems and methods of treating tissue defects in living beings.

公开(公告)号：US20220168478A1

公开(公告)日：2022-06-02

申请号：US17437864

申请日：2020-03-20

Applicant: DSM IP Assets B.V.

Inventor： Timothy RINGEISEN

IPC: A61L31/10 ,  A61L31/04 ,  A61L31/16 ,  A61L31/14 ,  A61L15/22 ,  A61L15/32 ,  A61L15/42 ,  A61L15/44 ,  A61F13/12

Abstract: Disclosed are nasal dressings and nasal stents comprising a collagen foam. Also disclosed are methods of making and using such nasal dressings and nasal stents. In an embodiment, a nasal dressing or nasal stent is formed by a method comprising the steps of: forming an aqueous mixture of from 5 to 25 wt % of acid-soluble collagen and from 75 to 95 wt % of collagen fibers, both based on the total solids content of the aqueous mixture, placing the aqueous mixture into a mold, freeze-drying the aqueous mixture while in the mold, thereby forming a collagen foam, and cross-linking the collagen foam.

公开(公告)号：US20200324026A1

公开(公告)日：2020-10-15

申请号：US16305117

申请日：2017-06-12

Applicant: DSM IP ASSETS B.V

Inventor： Andrew FALLIS ,  Steven LEONHARDT ,  Justin KONTRA ,  Rakesh BATISH ,  Timothy RINGEISEN

IPC: A61L27/46 ,  A61L27/58 ,  A61L27/52

Abstract: The invention provides composite materials that form a biocompatible and bioresorbable settable ceramic-forming composition, and that possesses high strength when set and other desirable mechanical properties. The composite materials may include additive materials that provide beneficial advantages in the handling and physical properties of the material. When a hydrated precursor, the composite material is capable of being injected through cannulas for placement in treatment sites. The composite material provided desirable handling properties and sets in a clinically relevant time period.