公开(公告)号：US20220395613A1

公开(公告)日：2022-12-15

申请号：US17845141

申请日：2022-06-21

Applicant: DSM IP Assets B.V.

Inventor： Andrew FALLIS ,  Steven LEONHARDT ,  Justin KONTRA ,  Rakesh BATISH ,  Timothy RINGEISEN

IPC: A61L27/46 ,  A61L27/52 ,  A61L27/58

Abstract: The invention provides composite materials that form a biocompatible and bioresorbable settable ceramic-forming composition, and that possesses high strength when set and other desirable mechanical properties. The composite materials may include additive materials that provide beneficial advantages in the handling and physical properties of the material. When a hydrated precursor, the composite material is capable of being injected through cannulas for placement in treatment sites. The composite material provided desirable handling properties and sets in a clinically relevant time period.

公开(公告)号：US20210147610A1

公开(公告)日：2021-05-20

申请号：US16621571

申请日：2018-06-18

Applicant: DSM IP Assets B.V.

Inventor： Jennifer AL-RASHID ,  John Andrew ZUPANCICH ,  Jayme PAULLIN ,  Jacob RIFFEY ,  Justin KONTRA

IPC: C08G18/75 ,  C08G18/73 ,  C08G18/66 ,  C08G18/61 ,  C08G18/48 ,  C08G18/38 ,  C08G18/32 ,  C08G18/24 ,  C08G18/10 ,  G02B1/04

Abstract: Disclosed herein are compositions and kits of materials for forming a component of a rigid gas permeable lens. An exemplary composition comprises a hydroxyl terminated polyurethane pre-polymer having an average of more than one hydroxyl group per molecule comprising: i) the residue of an aliphatic diisocyanate, a block of comprising polysiloxane and a block comprising hydrophobic poly(alkylene oxide), or ii) the residue of an aliphatic diisocyanate, a block comprising fluoroalkyl or fluoroalkyl ether, and a block of comprising hydrophobic poly(alkylene oxide). The composition further comprises a free aliphatic diisocyanate and a monomeric polyol, or a propoxylate thereof. The average number of hydroxyl groups of the hydroxyl terminated pre-polymer plus the average number of hydroxyl groups of the monomeric polyol, or a propoxylate thereof is equal to from 4.5 to 5.5. Kits of materials comprising elements that when combined form the composition are also disclosed. Further disclosed are articles and ocular devices comprising components formed from the compositions or kits.

公开(公告)号：US20200324026A1

公开(公告)日：2020-10-15

申请号：US16305117

申请日：2017-06-12

Applicant: DSM IP ASSETS B.V

Inventor： Andrew FALLIS ,  Steven LEONHARDT ,  Justin KONTRA ,  Rakesh BATISH ,  Timothy RINGEISEN

IPC: A61L27/46 ,  A61L27/58 ,  A61L27/52

Abstract: The invention provides composite materials that form a biocompatible and bioresorbable settable ceramic-forming composition, and that possesses high strength when set and other desirable mechanical properties. The composite materials may include additive materials that provide beneficial advantages in the handling and physical properties of the material. When a hydrated precursor, the composite material is capable of being injected through cannulas for placement in treatment sites. The composite material provided desirable handling properties and sets in a clinically relevant time period.