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公开(公告)号：US20230159881A1
公开(公告)日：2023-05-25
申请号：US18094446
申请日：2023-01-09
Applicant: DSM IP Assets B.V.
Inventor： John E. NASH , William T. FISHER , Gino BRADICA
IPC: C12M1/00
CPC classification number: C12M47/04 , C12M47/02 , C12N5/0667
Abstract: A centrifuge device is provided for the sizing and separation of constituents of a biologic mixture, e.g., adipose tissue. The device provides for the mechanical breaking down of the fibrous structure in the tissue by centrifugation causing the tissue to pass through a mesh element, or a sizing helix, or an extrusion element, whereupon the material is reduced to a slurry. This processed material may then be separated by centrifugation into its constituents, in order to harvest the fraction containing the multipotent cells. These multipotent cells may be utilized for various medical procedures to stimulate healing and tissue regeneration.
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公开(公告)号：US20210338893A1
公开(公告)日：2021-11-04
申请号：US17283263
申请日：2019-10-10
Applicant: DSM IP Assets B.V.
Inventor： William T. FISHER , Amit DEKA
IPC: A61L27/36
Abstract: Disclosed herein are devices and methods for processing biologic tissues, such as adipose tissue. The devices comprise a rotatable chamber and a fiber collector within. The fiber collector is configured to capture fibers from a sample. The devices further comprise a drive unit configured to rotate the rotatable chamber, thereby producing a centrifugal field, whereupon when a sample of biologic tissue is present in the rotatable chamber, the sample stratifies into at least two constituent layers as a function of the differing specific gravities of the constituents
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公开(公告)号：US20220031925A1
公开(公告)日：2022-02-03
申请号：US17501281
申请日：2021-10-14
Applicant: DSM IP Assets B.V.
Inventor： John E. NASH , William T. FISHER , Douglas G. EVANS
Abstract: Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) and or platelet poor plasma (PPP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma into separate receivers while retaining the platelets and other factors in the centrifuge chamber. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants.
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公开(公告)号：US20210077123A1
公开(公告)日：2021-03-18
申请号：US16962464
申请日：2019-01-25
Applicant: DSM IP Assets B.V.
Inventor： William T. FISHER , Timothy RINGEISEN , Gino BRADICA
Abstract: Disclosed are radially expanding debridement tools configured to pass through an access channel present in a first tissue of a living being, expand radially, and create a void in a second tissue of the living being upon being advanced distally through the access channel and into the second tissue while being rotated, wherein the shape of the void comprises at least one step. Further disclosed are debridement systems and methods of treating tissue defects in living beings.
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公开(公告)号：US20240148953A1
公开(公告)日：2024-05-09
申请号：US18544739
申请日：2023-12-19
Applicant: DSM IP Assets B.V.
Inventor： John E. NASH , William T. FISHER , Douglas G. EVANS
CPC classification number: A61M1/3693 , A61M1/3696 , B01D21/262 , B01D21/34 , B04B1/02 , B04B1/18 , B04B5/0407 , B04B5/0442 , B04B7/08 , B04B11/04 , B04B1/14
Abstract: Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) and or platelet poor plasma (PPP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma into separate receivers while retaining the platelets and other factors in the centrifuge chamber. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants.
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Patent Agency Ranking
公开(公告)号：US20200299632A1
公开(公告)日：2020-09-24
申请号：US16893464
申请日：2020-06-05
Applicant: DSM IP Assets B.V.
Inventor： John E. NASH , William T. FISHER , Gino BRADICA
IPC: C12M1/00
Abstract: A centrifuge device is provided for the sizing and separation of constituents of a biologic mixture, e.g., adipose tissue. The device provides for the mechanical breaking down of the fibrous structure in the tissue by centrifugation causing the tissue to pass through a mesh element, or a sizing helix, or an extrusion element, whereupon the material is reduced to a slurry. This processed material may then be separated by centrifugation into its constituents, in order to harvest the fraction containing the multipotent cells. These multipotent cells may be utilized for various medical procedures to stimulate healing and tissue regeneration.
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公开(公告)号：US20240367181A1
公开(公告)日：2024-11-07
申请号：US18686460
申请日：2022-08-26
Applicant: DSM IP Assets B.V.
Inventor： William T. FISHER , Amit DEKA
Abstract: Disclosed herein are devices and methods for processing biologic tissues, such as adipose tissue or whole blood, via centrifugation, An annular cavity is present, typically at the widest interior point of a rotatable chamber. The device is operable such that a sample of biologic tissue present in the rotatable chamber can be stratified into at least two constituent layers as a function of the differing specific gravities of the constituents and at least a portion of one of the constituent layers captured in the annular cavity.
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公开(公告)号：US20230293214A1
公开(公告)日：2023-09-21
申请号：US18198902
申请日：2023-05-18
Applicant: DSM IP Assets B.V.
Inventor： William T. FISHER , Dennis M. SAURO , Timothy O'NEIL
CPC classification number: A61B17/8861 , A61B17/82 , A61B2017/00871
Abstract: Disclosed are cable fixation devices. The fixation devices are configured to keep tension in a polymer cable to secure a fracture or for other medical uses. In an embodiment, a fixation device for securing a fracture comprises a body and a piercing element, wherein the fixation device is configured to pierce a polymer cable arranged in the body by engaging the piercing element. In an embodiment, the fixation device further comprises a retensioning member, which may be operated to increase tension in the polymer cable after the polymer has been pierced by the piecing element. In an embodiment, the polymer cable comprises a braid or a yarn.
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公开(公告)号：US20200268426A1
公开(公告)日：2020-08-27
申请号：US16646485
申请日：2018-09-14
Applicant: DSM IP Assets B.V.
Inventor： William T. FISHER , Dennis M. SAURO , Timothy O'NEIL
Abstract: Disclosed are cable fixation devices. The fixation devices are configured to keep tension in a polymer cable to secure a fracture or for other medical uses. In an embodiment, a fixation device for securing a fracture comprises a body and a piercing element, wherein the fixation device is configured to pierce a polymer cable arranged in the body by engaging the piercing element. In an embodiment, the fixation device further comprises a retensioning member, which may be operated to increase tension in the polymer cable after the polymer has been pierced by the piecing element. In an embodiment, the polymer cable comprises a braid or a yarn.
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公开(公告)号：US20200222915A1
公开(公告)日：2020-07-16
申请号：US16833743
申请日：2020-03-30
Applicant: DSM IP Assets B.V.
Inventor： John E. NASH , William T. FISHER , Douglas G. EVANS
Abstract: Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) and or platelet poor plasma (PPP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma into separate receivers while retaining the platelets and other factors in the centrifuge chamber. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants.
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