公开(公告)号：US08859855B2

公开(公告)日：2014-10-14

申请号：US13633770

申请日：2012-10-02

Applicant: DSM IP Assets B.V.

Inventor： Craig A. Weaver ,  Ross Zirkle ,  Daniel H. Doherty ,  James G. Metz

IPC: A01H5/00 ,  A01H5/10 ,  C12N15/82 ,  C12N1/20 ,  C07H21/04 ,  C12P7/64 ,  C12P7/62 ,  C12N9/00 ,  C12N15/52

CPC classification number: C12P7/6427 ,  C12N9/93 ,  C12N15/52 ,  C12N15/8247 ,  C12N15/8273 ,  C12P7/62 ,  C12P7/625 ,  C12P7/6472

Abstract: Disclosed are chimeric polyunsaturated fatty acid (PUFA) olyketide synthase (PKS) proteins and chimeric PUFA PKS systems, including chimeric PUFA PKS proteins and systems derived from Schizochytrium and Thraustochytrium. Disclosed are nucleic acids and proteins encoding such chimeric PUFA PKS proteins and systems, genetically modified organisms comprising such chimeric PUFA PKS proteins and systems, and methods of making and using such chimeric PUFA PKS proteins and systems.

Abstract translation: 公开了嵌合多不饱和脂肪酸（PUFA）合成酮合成酶（PKS）蛋白和嵌合PUFA PKS系统，包括嵌合PUFA PKS蛋白和源自裂殖壶菌和破囊壶菌的系统。 公开了编码这种嵌合PUFA PKS蛋白质和系统的核酸和蛋白质，包含这种嵌合PUFA PKS蛋白质和系统的遗传修饰的生物体，以及制备和使用这种嵌合PUFA PKS蛋白质和系统的方法。

公开(公告)号：US20130143281A1

公开(公告)日：2013-06-06

申请号：US13633770

申请日：2012-10-02

Applicant: DSM IP Assets B.V.,

Inventor： Craig A. WEAVER ,  Ross Zirkle ,  Daniel H. Doherty ,  James G. Metz

IPC: C12P7/64

CPC classification number: C12P7/6427 ,  C12N9/93 ,  C12N15/52 ,  C12N15/8247 ,  C12N15/8273 ,  C12P7/62 ,  C12P7/625 ,  C12P7/6472

Abstract: Disclosed are chimeric polyunsaturated fatty acid (PUFA) olyketide synthase (PKS) proteins and chimeric PUFA PKS systems, including chimeric PUFA PKS proteins and systems derived from Schizochytrium and Thraustochytrium. Disclosed are nucleic acids and proteins encoding such chimeric PUFA PKS proteins and systems, genetically modified organisms comprising such chimeric PUFA PKS proteins and systems, and methods of making and using such chimeric PUFA PKS proteins and systems.

Abstract translation: 公开了嵌合多不饱和脂肪酸（PUFA）合成酮合成酶（PKS）蛋白和嵌合PUFA PKS系统，包括嵌合PUFA PKS蛋白和源自裂殖壶菌和破囊壶菌的系统。 公开了编码这种嵌合PUFA PKS蛋白质和系统的核酸和蛋白质，包含这种嵌合PUFA PKS蛋白质和系统的遗传修饰的生物体，以及制备和使用这种嵌合PUFA PKS蛋白质和系统的方法。