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公开(公告)号：US12128158B2
公开(公告)日：2024-10-29
申请号：US18108038
申请日：2023-02-10
Applicant: DSM IP Assets B.V.
Inventor： Noel L. Davison , Henricus Johannes Arts , Aylvin Jorge Angelo Athanasius Dias , Anne Marie Persson , Ruud Jozef Regina Wilhelmus Peters
IPC: A61L31/08 , A61L17/04 , A61L17/14 , A61L27/18 , A61L27/32 , A61L27/34 , A61L31/06 , A61L31/10 , C08L75/04
CPC classification number: A61L31/086 , A61L17/04 , A61L17/145 , A61L27/18 , A61L27/32 , A61L27/34 , A61L31/06 , A61L31/10 , C08L75/04 , A61L2420/02 , A61L2430/02 , A61L2430/38
Abstract: The disclosure relates to a method of making a bioceramic coating on a fibrous article for use in a medical implant, comprising steps of providing an article comprising fibers made from a biocompatible, non-biodegradable polymer; coating at least the fibers that will be in contact with bone upon use as an implant with a solution of a coating polymer to result in coated fibers having a coating polymer layer; treating the coated fibers with a dispersion of bioactive ceramic particles 0.01-10 μm in a treating solvent comprising a solvent for the coating polymer in at least one step; and substantially removing the treating solvent; to result in the particles being partly embedded in the coating polymer layer of the coated fibers.
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公开(公告)号：US12171905B2
公开(公告)日：2024-12-24
申请号：US17430734
申请日：2020-03-02
Applicant: DSM IP Assets B.V.
Abstract: Disclosed herein is a medical implant component comprising a composite biotextile, which biotextile comprises i) a polyolefin fibrous construct comprising at least one strand with titer of 2-250 dtex, tensile strength of at least 10 cN/dtex and comprising high molar mass polyolefin fibers and ii) a coating comprising a biocompatible and biostable polyurethane elastomer comprising a polysiloxane segment and/or having one or more hydrophobic endgroups, wherein the polyurethane coating is present on at least part of the surface of the biotextile and in an amount of 2.5-90 mass % based on composite biotextile. Such composite biotextile, like a partly coated woven fabric, shows an advantageous combination of good biocompatibility, especially hemocompatibility, high strength and pliability, and laser cuttability; allowing to make pieces of fabric having well-defined regular edges that have high suture retention strength. The invention also provides a method of making said composite biotextile. Further embodiments concern the use of such biotextile in or as medical implant component for an implantable medical device and the use of such medical implant component in making an implantable medical device; such as in orthopedic applications and cardiovascular implants. Other embodiments include such medical devices or implants comprising said medical implant component.
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公开(公告)号：US12016977B2
公开(公告)日：2024-06-25
申请号：US16753355
申请日：2018-10-05
Applicant: DSM IP Assets B.V.
Inventor： Noel L. Davison , Henricus Johannes Arts , Aylvin Jorge Angelo Athanasius Dias , Anne Marie Persson , Ruud Jozef Regina Wilhelmus Peters
IPC: A61L31/08 , A61L17/04 , A61L17/14 , A61L27/18 , A61L27/32 , A61L27/34 , A61L31/06 , A61L31/10 , C08L75/04
CPC classification number: A61L31/086 , A61L17/04 , A61L17/145 , A61L27/18 , A61L27/32 , A61L27/34 , A61L31/06 , A61L31/10 , C08L75/04 , A61L2420/02 , A61L2430/02 , A61L2430/38
Abstract: The disclosure relates to a method of making a bioceramic coating on a fibrous article for use in a medical implant, comprising steps of providing an article comprising fibers made from a biocompatible, non-biodegradable polymer; coating at least the fibers that will be in contact with bone upon use as an implant with a solution of a coating polymer to result in coated fibers having a coating polymer layer; treating the coated fibers with a dispersion of bioactive ceramic particles 0.01-10 μm in a treating solvent comprising a solvent for the coating polymer in at least one step; and substantially removing the treating solvent; to result in the particles being partly embedded in the coating polymer layer of the coated fibers.
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4.发明授权公开(公告)号：US12171906B2
公开(公告)日：2024-12-24
申请号：US17430736
申请日：2020-03-02
Applicant: DSM IP Assets B.V.
Abstract: Disclosed herein is a method of making a composite fabric for use in or as a medical implant component, the method comprising steps of providing a textile comprising at least one strand having titer of 2-250 dtex and comprising fibers made from a biocompatible and biostable synthetic polymer; determining locations on the textile where a cut is to be made for an intended use of the textile; optionally pretreating the textile at least at the determined locations on at least one side of the textile with a high-energy source to activate the surface; solution coating the textile at least at a determined location with a coating composition comprising a biocompatible and biostable polyurethane elastomer and a solvent for the polyurethane; removing the solvent from the coated textile; and laser cutting the coated textile as obtained at least a one coated location with an ultra-short pulse laser; to result in a composite biotextile wherein polyurethane is present in an amount of 2.5-90 mass % based on composite biotextile and polyurethane is present at least at a laser-cut edge. Such composite biotextile as made shows an advantageous combination of good biocompatibility, especially hemocompatibility, high strength and pliability, and has well-defined regular edges that have high suture retention strength. Further embodiments concern the use of such composite biotextile in or as medical implant component for an implantable medical device; such as in orthopedic applications and cardiovascular implants. Other embodiments include such medical devices or implants comprising said composite biotextile or medical implant component.
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