专利检索 ap:("DSM Sinochem Pharmaceuticals Netherlands B.V." OR "Rijksuniversiteit Groningen") AND inv:"Arnold Jacob Mathieu Driessen" 第 1 页

1.

发明申请
MBTH-LIKE PROTEINS IN EUKARYOTIC NRPS-CATALYZED PROCESSES 审中-公开

公开(公告)号：US20190233477A1

公开(公告)日：2019-08-01

申请号：US16093943

申请日：2017-04-13

申请人： DSM Sinochem Pharmaceuticals Netherlands B.V. , Rijksuniversiteit Groningen

发明人： Roelof Ary Lans Bovenberg , Ulrike Maria Muller , Arnold Jacob Mathieu Driessen , Pohl Carsten , Reto Daniel Zwahlen

IPC分类号： C07K14/195 , C12P15/00 , C12P17/02 , C12P35/00 , C12P37/00 , C12N1/14

CPC分类号： C07K14/195 , C12N1/14 , C12P15/00 , C12P17/02 , C12P35/00 , C12P37/00

摘要： The present invention relates to a method to improve the production of a secondary metabolite catalyzed by a non-ribosomal peptide synthetase comprising contacting in a eukaryotic host a eukaryotic non-ribosomal peptide synthetase with an MbtH-like protein. The present invention further relates to a composition comprising a eukaryotic non-ribosomal peptide synthetase that is not a hybrid and a prokaryotic MbtH and to a eukaryotic host cell comprising a non-ribosomal peptide synthetase and a polynucleotide allowing the expression of an MbtH-like protein.