公开(公告)号：US10543239B2

公开(公告)日：2020-01-28

申请号：US14983827

申请日：2015-12-30

申请人： DUPONT NUTRITION BIOSCIENCES APS

发明人： Remy Burcelin ,  Didier Carcano ,  Pierre Desreumaux ,  Sampo Lahtinen ,  Nina Rautonen ,  Heli Putaala ,  Kirsti Tiihonen ,  Rodolphe Barrangou

IPC分类号： A61K35/747 ,  A61K35/745 ,  A61K35/74 ,  A61K35/00

摘要： The invention relates to use of a bacterium selected from a lactic acid bacterium, a Bifidobacterium or a mixture of any thereof for treating metabolic endotoxemia, inhibiting bacterial translocation and regulating lipid absorption in a mammal.

公开(公告)号：US09951342B2

公开(公告)日：2018-04-24

申请号：US14570994

申请日：2014-12-15

申请人： DUPONT NUTRITION BIOSCIENCES APS

发明人： Rodolphe Barrangou ,  Christophe Fremaux ,  Phillippe Horvath ,  Dennis Romero ,  Patrick Boyaval

IPC分类号： C12Q1/68 ,  C12N15/74 ,  A23C9/123 ,  C12N1/20 ,  C12Q1/70

CPC分类号： C12N15/746 ,  A23C9/123 ,  A23C9/1238 ,  A23C2220/202 ,  A23Y2240/75 ,  C12N1/20 ,  C12N2795/00011 ,  C12Q1/70 ,  C12Q2525/151

摘要： The present invention provides methods and compositions related to modulating the resistance of a cell against a target nucleic acid or a transcription product thereof. In some preferred embodiments, the present invention provides compositions and methods for the use of one or more cas genes or proteins for modulating the resistance of a cell against a target nucleic acid or a transcription product thereof. In some embodiments, the present invention provides methods and compositions that find use in the development and use of strain combinations and starter culture rotations. In additional embodiments, the present invention provides methods for labelling and/or identifying bacteria. In some preferred embodiments, the present invention provides methods for the use of CRISPR loci to determine the potential virulence of a phage against a cell and the use of CRISPR-cas to modulate the genetic sequence of a phage for increased virulence level. In still further embodiments, the present invention provides means and compositions for the development and use of phages as biocontrol agents.

公开(公告)号：US20140199767A1

公开(公告)日：2014-07-17

申请号：US13960796

申请日：2013-08-06

申请人： DUPONT NUTRITION BIOSCIENCES APS

发明人： Rodolphe Barrangou ,  Patrick Boyaval ,  Christophe Fremaux ,  Philippe Horvath ,  Dennis Romero

IPC分类号： C12N15/74

CPC分类号： C12N15/746 ,  A23K20/10 ,  A23L33/135 ,  A23V2002/00 ,  C12N15/74 ,  C12Q1/689 ,  C12Q1/70 ,  C12Q2600/156 ,  C12Q2525/151

摘要： The present invention relates to the use of one or more cas genes for modulating resistance in a cell against a target nucleic acid or a transcription product thereof.

摘要翻译： 本发明涉及一种或多种cas基因用于调节细胞中针对靶核酸或其转录产物的抗性的用途。

公开(公告)号：US20170037416A1

公开(公告)日：2017-02-09

申请号：US15229103

申请日：2016-08-04

申请人： DUPONT NUTRITION BIOSCIENCES APS

发明人： Rodolphe Barrangou ,  Patrick Boyaval ,  Christophe Fremaux ,  Philippe Horvath ,  Dennis Romero

IPC分类号： C12N15/74 ,  A23K20/10 ,  A23L33/135

CPC分类号： C12N15/746 ,  A23K20/10 ,  A23L33/135 ,  A23V2002/00 ,  C12N15/74 ,  C12Q1/689 ,  C12Q1/70 ,  C12Q2600/156 ,  C12Q2525/151

摘要： The present invention relates to the use of one or more cas genes for modulating resistance in a cell against a target nucleic acid or a transcription product thereof.

摘要翻译： 本发明涉及一种或多种cas基因用于调节细胞中针对靶核酸或其转录产物的抗性的用途。