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公开(公告)号：US20170037416A1
公开(公告)日：2017-02-09
申请号：US15229103
申请日：2016-08-04
IPC分类号： C12N15/74 , A23K20/10 , A23L33/135
CPC分类号： C12N15/746 , A23K20/10 , A23L33/135 , A23V2002/00 , C12N15/74 , C12Q1/689 , C12Q1/70 , C12Q2600/156 , C12Q2525/151
摘要： The present invention relates to the use of one or more cas genes for modulating resistance in a cell against a target nucleic acid or a transcription product thereof.
摘要翻译： 本发明涉及一种或多种cas基因用于调节细胞中针对靶核酸或其转录产物的抗性的用途。
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公开(公告)号：US10307445B2
公开(公告)日：2019-06-04
申请号：US14860071
申请日：2015-09-21
IPC分类号： C12N1/20 , C12P7/66 , A61K35/74 , A23C9/123 , A23C19/032 , C12R1/01 , C12R1/46 , A23K10/18 , A23L33/135 , A61K35/744 , A23L33/15
摘要： The invention relates to bacterial strains having an outstanding ability to produce menaquinone and to applications thereof.
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3.发明申请BACTERIAL STRAINS HAVING AN OUTSTANDING ABILITY TO PRODUCE MENAQUINONE 审中-公开具有生产MENAQUINONE的优异能力的细菌菌株公开(公告)号：US20160008411A1
公开(公告)日：2016-01-14
申请号：US14860071
申请日：2015-09-21
CPC分类号： A61K35/74 , A23C9/1234 , A23C9/1236 , A23C19/0323 , A23K10/18 , A23L33/135 , A23L33/15 , A23V2002/00 , A23Y2240/21 , A23Y2240/41 , A23Y2320/39 , A61K35/744 , C12N1/20 , C12P7/66 , C12R1/01 , C12R1/46 , A23V2200/318 , A23V2200/326 , A23V2250/714
摘要： The invention relates to bacterial strains having an outstanding ability to produce menaquinone and to applications thereof.
摘要翻译： 本发明涉及具有突出的生产美奴醌的能力及其应用的细菌菌株。
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公开(公告)号：US20240180986A1
公开(公告)日：2024-06-06
申请号：US18553229
申请日：2022-03-30
IPC分类号： A61K36/064 , A61P29/00
CPC分类号： A61K36/064 , A61P29/00
摘要： Provided herein are compositions containing fungus, e.g., yeast, useful for treating and/or preventing gastrointestinal inflammation, and/or diseases, disorders, or conditions associated therewith, in a subject in need thereof and methods for using the same.
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公开(公告)号：US20230332183A1
公开(公告)日：2023-10-19
申请号：US18112968
申请日：2023-02-22
发明人： Christophe Fremaux , Philippe Horvath , Patrick Boyaval , Pascal Hols , David Blandine , Amandine Radziejwoski , Laetitia Fontaine , Frederic Toussaint
CPC分类号： C12N15/902 , C07K7/00 , C12Q1/02
摘要： The present invention relates to a method for transforming a strain of the Lactococcus genus through natural competence. The present invention further relates to strains obtained or obtainable by said method. The present invention also relates to a method for identifying a strain of the Lactococcus genus which is transformable through natural competence.
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6.发明授权Method for transforming a bacterium belonging to the streptococcus genus by natural competence 有权通过天然能力转化属于链球菌属的细菌的方法公开(公告)号：US09243254B2
公开(公告)日：2016-01-26
申请号：US14162398
申请日：2014-01-23
IPC分类号： A61K39/09 , C07K14/195 , C12N15/67 , A23K1/00 , A23K1/16 , C07K14/315 , C12N15/87 , A23L1/30 , C07K7/06 , C07K7/08 , C07K14/00
CPC分类号： C12N15/67 , A23K10/16 , A23K10/18 , A23K20/147 , A23L33/135 , A61K39/092 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/315 , C12N15/87
摘要： The present invention relates to peptides, nucleic acids and methods for transforming a bacterium belonging to the Streptococcus genus by natural competence and their use in the food and feed industry.
摘要翻译： 本发明涉及通过天然能力转化属于链球菌属的细菌的肽，核酸和方法及其在食品和饲料工业中的用途。
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7.发明申请公开(公告)号：US20140134295A1
公开(公告)日：2014-05-15
申请号：US14162398
申请日：2014-01-23
CPC分类号： C12N15/67 , A23K10/16 , A23K10/18 , A23K20/147 , A23L33/135 , A61K39/092 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/315 , C12N15/87
摘要： The present invention relates to peptides, nucleic acids and methods for transforming a bacterium belonging to the Streptococcus genus by natural competence and their use in the food and feed industry.
摘要翻译： 本发明涉及通过天然能力转化属于链球菌属的细菌的肽，核酸和方法及其在食品和饲料工业中的用途。
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公开(公告)号：US20200087686A1
公开(公告)日：2020-03-19
申请号：US16469784
申请日：2017-12-19
发明人： Christophe Fremaux , Philippe Horvath , Patrick Boyaval , Pascal Hols , David Blandine , Amandine Radziejwoski , Laetitia Fontaine , Frederic Toussaint
摘要： The present invention relates to a method for transforming a strain of the Lactococcus genus through natural competence. The present invention further relates to strains obtained or obtainable by said method. The present invention also relates to a method for identifying a strain of the Lactococcus genus which is transformable through natural competence.
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公开(公告)号：US09951342B2
公开(公告)日：2018-04-24
申请号：US14570994
申请日：2014-12-15
CPC分类号： C12N15/746 , A23C9/123 , A23C9/1238 , A23C2220/202 , A23Y2240/75 , C12N1/20 , C12N2795/00011 , C12Q1/70 , C12Q2525/151
摘要： The present invention provides methods and compositions related to modulating the resistance of a cell against a target nucleic acid or a transcription product thereof. In some preferred embodiments, the present invention provides compositions and methods for the use of one or more cas genes or proteins for modulating the resistance of a cell against a target nucleic acid or a transcription product thereof. In some embodiments, the present invention provides methods and compositions that find use in the development and use of strain combinations and starter culture rotations. In additional embodiments, the present invention provides methods for labelling and/or identifying bacteria. In some preferred embodiments, the present invention provides methods for the use of CRISPR loci to determine the potential virulence of a phage against a cell and the use of CRISPR-cas to modulate the genetic sequence of a phage for increased virulence level. In still further embodiments, the present invention provides means and compositions for the development and use of phages as biocontrol agents.
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公开(公告)号：US20140199767A1
公开(公告)日：2014-07-17
申请号：US13960796
申请日：2013-08-06
IPC分类号： C12N15/74
CPC分类号： C12N15/746 , A23K20/10 , A23L33/135 , A23V2002/00 , C12N15/74 , C12Q1/689 , C12Q1/70 , C12Q2600/156 , C12Q2525/151
摘要： The present invention relates to the use of one or more cas genes for modulating resistance in a cell against a target nucleic acid or a transcription product thereof.
摘要翻译： 本发明涉及一种或多种cas基因用于调节细胞中针对靶核酸或其转录产物的抗性的用途。
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