公开(公告)号：US20070259428A1

公开(公告)日：2007-11-08

申请号：US10567439

申请日：2004-07-05

申请人： Daijie Chen ,  Zhilong Wang ,  Mei Ge ,  Yiping Jin ,  Weidong Ye

发明人： Daijie Chen ,  Zhilong Wang ,  Mei Ge ,  Yiping Jin ,  Weidong Ye

IPC分类号： C12N15/87

CPC分类号： C12P33/02 ,  C12N1/38

摘要： The invention relates to the field of microbial technology. It discloses a method to apply the cloud point system (CPS) in biotransformation by selecting one or more types of nonionic surfactant to form a aqueous system with a cloud point below the microbial transformation temperature, which serves as transformation medium. The method disclosed is suitable in particular for microbial transformation of hydrophobic compounds, for the system where substrate or product inhibits microbial growth or where product is further degraded by microbes. The CPS in the present invention forms a microemulsion of water-in-oil and oil-in-water, where the drops of surfactant is able to solubilize, serving as substrate reservoir and product extractant. This enhances bioavailability of substrates and elimination of product inhibition. The large water vesicles existing in the continuous surfactant phase provide aqueous environment to the cells where they can be sheltered from detrimental effects of surfactants, resulting in improvement of biocompatibililty.

摘要翻译： 本发明涉及微生物技术领域。 它公开了一种通过选择一种或多种类型的非离子表面活性剂来应用浊点系统（CPS）进行生物转化的方法，以形成低于微生物转化温度的浊点的水系，其作为转化介质。 所公开的方法特别适用于疏水化合物的微生物转化，其中底物或产物抑制微生物生长或其中产物被微生物进一步降解的系统。 本发明中的CPS形成了油包水和水包油的微乳液，其中表面活性剂的液滴能够溶解，作为底物贮存器和产物萃取剂。 这增强了底物的生物利用度和消除了产物的抑制作用。 存在于连续表面活性剂相中的大水泡为细胞提供水环境，在那里可以避免表面活性剂的不利影响，导致生物相容性的提高。

公开(公告)号：US20090054772A1

公开(公告)日：2009-02-26

申请号：US11883097

申请日：2005-08-26

申请人： Tao Lin ,  Wenzhi Chen ,  Yingang Wen ,  Zhibiao Wang ,  Zhilong Wang

发明人： Tao Lin ,  Wenzhi Chen ,  Yingang Wen ,  Zhibiao Wang ,  Zhilong Wang

IPC分类号： A61B8/00 ,  A61N7/00

CPC分类号： A61N7/02 ,  A61B90/14 ,  A61B2090/378

摘要： The present invention pertains to an ultrasound therapy system and more specifically, to a high-intensity focused ultrasound (HIFU) therapy apparatus guided by image registration and fusion method. The therapy system of the present invention comprises a central control means; an acoustic energy applicator; a mechanical driving and locating means of said acoustic energy applicator; a real-time B-mode ultrasound image guiding device. Further the therapy system of the present invention comprises an immobilization means for body position. By the help of this immobilization means for body position, real-time B-mode ultrasound images can be registered with diagnosis images, and then on the basis of registration, said B-mode ultrasound images are fused with said diagnosis images for guiding said therapy. Comparing to the existed technical solutions in this field, the present invention has effectively solved the difficult problems in high-intensity focused ultrasound therapy and particularly for tumor treatment with a low cost. And it provides a very practical technical solution, which can be easily applied to clinical treatment of tumors.

摘要翻译： 本发明涉及一种超声治疗系统，更具体地涉及由图像配准和融合方法引导的高强度聚焦超声（HIFU）治疗装置。 本发明的治疗系统包括中央控制装置; 声能施加器; 所述声能施加器的机械驱动和定位装置; 实时B模式超声图像引导装置。 此外，本发明的治疗系统包括用于身体位置的固定装置。 借助于该身体位置的固定装置，实时B模式超声图像可以与诊断图像一起登记，然后在登记的基础上，将所述B模式超声图像与用于引导所述治疗的所述诊断图像融合 。 与现有技术方案相比，本发明有效地解决了高强度聚焦超声治疗中的困难问题，特别是低成本的肿瘤治疗。 它提供了一个非常实用的技术解决方案，可以很容易地应用于肿瘤的临床治疗。

公开(公告)号：US20080139973A1

公开(公告)日：2008-06-12

申请号：US11794931

申请日：2005-09-02

申请人： Zhibiao Wang ,  Faqi Li ,  Yanbing Xiao ,  Ziwen Xiao ,  Liping Liu ,  Zhilong Wang

发明人： Zhibiao Wang ,  Faqi Li ,  Yanbing Xiao ,  Ziwen Xiao ,  Liping Liu ,  Zhilong Wang

IPC分类号： A61N7/02

CPC分类号： A61K41/0033 ,  A61K9/0019 ,  A61K9/107 ,  A61K9/127 ,  A61K31/685

摘要： The present invention discloses a particle enhancement agent for high intensity focused ultrasound (HIFU) treatment, which can increase acoustic energy deposition at the target location during HIFU treatment. The enhancement agent comprises a discontinuous phase comprised of a core material encapsulated by a membrane-forming material and a continuous phase comprising of aqueous medium. The discontinuous phase is uniformly dispersed in the continuous phase and the particle size of the discontinuous phase ranges from 0.1-8 μm; the amount of the membrane-forming material in the enhancement agent is 0.1-100 g/L; the core material is comprised of a liquid that does not undergo a liquid-gas phase transition at 38-100° C., and the amount of core material in the enhancement agent is 5-200 g/L.

摘要翻译： 本发明公开了一种用于高强度聚焦超声（HIFU）处理的颗粒增强剂，其可以在HIFU处理期间增加目标位置处的声能沉积。 增强剂包括由膜形成材料包封的芯材料和包含水性介质的连续相组成的不连续相。 不连续相均匀分散在连续相中，不连续相的粒径为0.1-8μm; 增塑剂中的成膜材料的量为0.1-100g / L; 核心材料由在38-100℃不经历液 - 气相变的液体组成，增强剂中芯材的量为5-200g / L。

公开(公告)号：US20050080359A1

公开(公告)日：2005-04-14

申请号：US10499341

申请日：2002-12-16

申请人： Chunliang Zhao ,  Zhibiao Wang ,  Zhilong Wang ,  Fangwei Ye

发明人： Chunliang Zhao ,  Zhibiao Wang ,  Zhilong Wang ,  Fangwei Ye

IPC分类号： A61B18/00 ,  A61N7/02 ,  A61N7/00

CPC分类号： A61N7/02 ,  A61B2018/00023

摘要： The invention provides an ultrasound therapeutic apparatus for treating skin lesions of human being, comprising a controlling device, an ultrasound transducer transmitting the therapeutic ultrasound beam to the subject, a focusing means. Said controlling device is the electrical control system of the ultrasound therapeutic apparatus. Said ultrasound transducer and said focusing means are placed in an ultrasound applicator, which can be held by hand. The ultrasound applicator, which can be held by hand, includes a handle and a housing forming a lumen and the said ultrasound transducer and said focusing means are placed in the said lumen. The ultrasound applicator can be held by clinicians' hand, performing a treatment on skin lesions of human being including the skin lesions of gynecology more conveniently.

摘要翻译： 本发明提供一种用于治疗人的皮肤损伤的超声治疗装置，包括控制装置，将治疗性超声波束传送到对象的超声波换能器，聚焦装置。 所述控制装置是超声治疗装置的电气控制系统。 所述超声波换能器和所述聚焦装置放置在可由手持的超声波施加器中。 可以手持的超声波施加器包括手柄和形成内腔的壳体，并且所述超声波换能器和所述聚焦装置被放置在所述内腔中。 超声波治疗仪可由临床医生掌握，更方便地对包括妇科皮肤病变在内的人体皮肤病变进行治疗。

公开(公告)号：US20090117052A1

公开(公告)日：2009-05-07

申请号：US11794928

申请日：2005-08-30

申请人： Zhibiao Wang ,  Faqi Li ,  Yanbing Xiao ,  Ziwen Xiao ,  Liping Liu ,  Zhilong Wang

发明人： Zhibiao Wang ,  Faqi Li ,  Yanbing Xiao ,  Ziwen Xiao ,  Liping Liu ,  Zhilong Wang

IPC分类号： A61B8/00 ,  A61N7/00

CPC分类号： A61K41/0052 ,  A61K41/0028

摘要： The present invention discloses an enhancement agent for high intensity focused ultrasound (HIFU) treatment, which is administered to a patient before HIFU treatment and can reduce the level of EEF at the target location to be treated with HIFU. EEF is presented by the expression: EEF=ηPt/V (unit: J/mm3), and refers to the HIFU energy needed to effectively treat a tumor per unit volume of the tumor, wherein, η=0.7; P refers to the total acoustic power of HIFU source (unit: W); t refers to the total time of HIFU treatment (unit: s); V refers to the volume of HIFU-induced lesions (unit: mm3). If the amount of EEF at the target location before administration of the enhancement agent is defined as EEF(base) and the amount of EEF at the target location after administration of the enhancement agent is defined as EEF(measurement), the ratio between EEF(base) and EEF(measurement) is more than 1, preferably more than 2, and more preferably over 4. The use of the enhancement agent for HIFU treatment of the present invention makes it possible to treat deep-seated tumors. In addition, patients with hepatic tumors can be effectively treated without removal of ribs. Accordingly, the present invention discloses methods for increasing acoustic energy deposition at target location during HIFU treatment and screening the enhancement agents for HIFU treatment.

摘要翻译： 本发明公开了一种用于高强度聚焦超声（HIFU）治疗的增强剂，其在HIFU治疗之前施用于患者，并且可以降低用HIFU治疗的目标位置处的EEF水平。 EEF由以下表达式表示：EEF = etaPt / V（单位：J / mm 3），并且是指每单位体积肿瘤有效治疗肿瘤所需的HIFU能量，其中eta = 0.7; P指HIFU源的总声功率（单位：W）; t指HIFU治疗的总时间（单位：s）; V指HIFU诱导的病变体积（单位：mm3）。 如果将增强剂施用前的目标位置处的EEF量定义为EEF（碱基），并且将施用增效剂后的目标位置处的EEF的量定义为EEF（测定），则EEF 碱）和EEF（测量）大于1，优选大于2，更优选超过4.使用本发明的HIFU治疗用增强剂可以治疗深层肿瘤。 此外，肝脏肿瘤患者可以有效地治疗，无需排除肋骨。 因此，本发明公开了在HIFU处理期间增加目标位置处的声能沉积并筛选用于HIFU处理的增强剂的方法。

公开(公告)号：US20080287835A1

公开(公告)日：2008-11-20

申请号：US11794929

申请日：2005-09-02

申请人： Chunliang Zhao ,  Zhibiao Wang ,  Zhilong Wang ,  Jin Bai

发明人： Chunliang Zhao ,  Zhibiao Wang ,  Zhilong Wang ,  Jin Bai

IPC分类号： A61N7/00

CPC分类号： A61N7/00

摘要： The present invention is to provide an integrated ultrasound therapy transducer. It includes a piezoelectric transducer to generate therapy ultrasound, a support to support the piezoelectric transducer, a power amplifying module to drive the piezoelectric transducer. Wherein both the power amplifying module and the piezoelectric transducer are installed within the enclosure of the therapy transducer. The advantages of the integrated ultrasound therapy transducer assembly of the present invention include minimizing ultrasound therapy equipment and to decrease its volume and weight; reducing the electromagnetic interference and radiation greatly; and realizing the consistent performances of the ultrasound therapy equipments in mass productions and making the ultrasound therapy equipments have interchangeability.

摘要翻译： 本发明是提供一种整合的超声治疗换能器。 它包括用于产生治疗超声的压电换能器，支撑压电换能器的支撑件，用于驱动压电换能器的功率放大模块。 其中功率放大模块和压电换能器都安装在治疗传感器的外壳内。 本发明的一体化超声治疗换能器组件的优点包括使超声治疗设备最小化并减小体积和重量; 大大降低电磁干扰和辐射; 实现超声波治疗设备在大规模生产中的一贯表现，使超声治疗设备具有互换性。

公开(公告)号：US20080281252A1

公开(公告)日：2008-11-13

申请号：US11883080

申请日：2005-08-31

申请人： Zhilong Wang ,  Zhibiao Wang ,  Jin Bai ,  Zhengai Xiong

发明人： Zhilong Wang ,  Zhibiao Wang ,  Jin Bai ,  Zhengai Xiong

IPC分类号： A61M5/00

CPC分类号： A61M31/00 ,  A61B1/32 ,  A61M29/00

摘要： The present invention generally relates to a medical apparatus. More particularly, the present invention relates to an apparatus for delivering a medium to body cavity of mammals including a human, especially to an apparatus for expanding rectum. Specifically, the present invention relates to the field of focused ultrasound treatment with a main purpose to provide an auxiliary device for ultrasound therapy applied to uterine myoma so as to avoid damage by ultrasound after focused within body. Therefore, the present invention provides an apparatus for blocking ultrasound, comprising (1) lead-in means for entering into said body cavity; and (2) accommodation means for containing ultrasound blocking medium, which enwraps the lead-in means outside.

摘要翻译： 本发明一般涉及一种医疗装置。 更具体地，本发明涉及一种用于将包括人的哺乳动物的介质输送到体腔的装置，特别涉及用于扩张直肠的装置。 具体而言，本发明涉及聚焦超声处理领域，其主要目的是提供一种应用于子宫肌瘤的超声治疗辅助装置，以避免超声在体内聚焦后的损伤。 因此，本发明提供一种用于阻挡超声波的装置，包括：（1）用于进入所述体腔的引入装置; 和（2）用于容纳超声阻挡介质的容纳装置，其将导入装置包裹在外部。

公开(公告)号：US20080260790A1

公开(公告)日：2008-10-23

申请号：US11794927

申请日：2005-08-30

申请人： Zhibiao Wang ,  Faqi Li ,  Liping Liu ,  Yanbing Xiao ,  Ziwen Xiao ,  Zhilong Wang

发明人： Zhibiao Wang ,  Faqi Li ,  Liping Liu ,  Yanbing Xiao ,  Ziwen Xiao ,  Zhilong Wang

IPC分类号： A61K9/50 ,  A61K33/42 ,  A61K33/10 ,  A61P35/00

CPC分类号： A61K33/10 ,  A61K31/575 ,  A61K31/66 ,  A61K33/42 ,  A61K41/0028 ,  A61K41/0052 ,  A61K45/06 ,  A61N7/02 ,  A61K2300/00

摘要： The present invention discloses a plasmid enhancement agent for high intensity focused ultrasound (HIFU) treatment, which can increase acoustic energy deposition at the target location during HIFU treatment. The enhancement agent comprises a nanometer-sized biocompatible solid. The present invention also discloses another plasmid enhancement agent for HIFU treatment, wherein, the enhancement agent comprises a discontinuous phase is comprised of a core material encapsulated by a membrane-forming material, and a continuous phase comprised of aqueous medium; the discontinuous phase is uniformly dispersed in the continuous phase and has a particle size ranging from 10-1000 nm; the amount of the membrane-forming material in the enhancement agent is 0.1-100g/L; and the core material comprises nanometer-sized biocompatible solid selected from the group consisting of magnetic biomaterials, hydroxylapatite, and calcium carbonate, and the amount of the core material in the enhancement agent is 0.1-150 g/L.

摘要翻译： 本发明公开了一种用于高强度聚焦超声（HIFU）处理的质粒增强剂，其可以在HIFU处理期间增加目标位置处的声能沉积。 增强剂包括纳米尺寸的生物相容性固体。 本发明还公开了另一种用于HIFU处理的质粒增强剂，其中增强剂包括不连续相，其包含由成膜材料包封的芯材料和由水性介质组成的连续相; 不连续相均匀分散在连续相中，粒径范围为10-1000nm; 增塑剂中的成膜材料的量为0.1-100g / L; 并且核心材料包括选自磁性生物材料，羟基磷灰石和碳酸钙的纳米尺寸的生物相容性固体，并且增强剂中的芯材料的量为0.1-150g / L。

公开(公告)号：US20130270180A1

公开(公告)日：2013-10-17

申请号：US13881016

申请日：2011-10-28

申请人： Xinjie Zhang ,  Anthony E. Allegrezza, JR. ,  Qi Zhao ,  Zhilong Wang

发明人： Xinjie Zhang ,  Anthony E. Allegrezza, JR. ,  Qi Zhao ,  Zhilong Wang

IPC分类号： B01D71/02

CPC分类号： B01D71/024 ,  B01D46/546 ,  B01D67/0046 ,  B01D67/0051 ,  B01D69/02 ,  B01D71/025 ,  B01D71/027 ,  B01D2239/025 ,  B01D2325/24 ,  Y10T156/10

摘要： Embodiments of the present invention disclose ceramic membranes having bonded ceramic nanowires. Methods of making ceramic membranes having bonded ceramic nanowires are also disclosed.

摘要翻译： 本发明的实施方案公开了具有结合陶瓷纳米线的陶瓷膜。 还公开了制造具有结合陶瓷纳米线的陶瓷膜的方法。

公开(公告)号：US08251929B2

公开(公告)日：2012-08-28

申请号：US11794929

申请日：2005-09-02

申请人： Chunliang Zhao ,  Zhibiao Wang ,  Zhilong Wang ,  Jin Bai

发明人： Chunliang Zhao ,  Zhibiao Wang ,  Zhilong Wang ,  Jin Bai

IPC分类号： A61N7/00

CPC分类号： A61N7/00

摘要： The present invention is to provide an integrated ultrasound therapy transducer. It includes a piezoelectric transducer to generate therapy ultrasound, a support to support the piezoelectric transducer, a power amplifying module to drive the piezoelectric transducer. Wherein both the power amplifying module and the piezoelectric transducer are installed within the enclosure of the therapy transducer. The advantages of the integrated ultrasound therapy transducer assembly of the present invention include minimizing ultrasound therapy equipment and to decrease its volume and weight; reducing the electromagnetic interference and radiation greatly; and realizing the consistent performances of the ultrasound therapy equipments in mass productions and making the ultrasound therapy equipments have interchangeability.

摘要翻译： 本发明是提供一种整合的超声治疗换能器。 它包括用于产生治疗超声的压电换能器，支撑压电换能器的支撑件，用于驱动压电换能器的功率放大模块。 其中功率放大模块和压电换能器都安装在治疗传感器的外壳内。 本发明的一体化超声治疗换能器组件的优点包括使超声治疗设备最小化并减小体积和重量; 大大降低电磁干扰和辐射; 实现超声波治疗设备在大规模生产中的一贯表现，使超声治疗设备具有互换性。