公开(公告)号：US20080138290A1

公开(公告)日：2008-06-12

申请号：US11794932

申请日：2005-09-02

申请人： Zhibiao Wang ,  Faqi Li ,  Ziwen Xiao ,  Yanbing Xiao ,  Liping Liu ,  Zhilong Wang

发明人： Zhibiao Wang ,  Faqi Li ,  Ziwen Xiao ,  Yanbing Xiao ,  Liping Liu ,  Zhilong Wang

IPC分类号： A61K49/22

CPC分类号： A61K41/0033 ,  A61K9/0009 ,  A61K9/0019 ,  A61K9/107 ,  A61K9/1075 ,  A61K31/685 ,  A61K49/226

摘要： The present invention discloses a fluorocarbon emulsion enhancement agent for HIFU treatment, which can increase acoustic energy deposition at the target location during HIFU treatment. The enhancement agent comprises a discontinuous phase comprising of a core material encapsulated by a membrane-forming material and a continuous phase comprised of aqueous medium; the discontinuous phase is uniformly dispersed in the continuous phase and the particle size of the discontinuous phase ranges from 0.1-2 μm; the amount of the membrane-forming material in the enhancement agent is 0.1-100 g/L; the core material is comprised of a liquid that undergoes a liquid-gas phase transition at 38-100° C., and the amount of the core material in the enhancement agent is 5-200 ml/L. The fluorocarbon emulsion enhancement agent for HIFU treatment of the present invention can significantly change the acoustic environment of the target location and can increase acoustic energy deposition at the target location during HIFU treatment.

摘要翻译： 本发明公开了一种用于HIFU处理的碳氟化合物乳液增强剂，其可以在HIFU处理期间增加目标位置处的声能沉积。 增强剂包括由膜形成材料包封的芯材料和由水性介质组成的连续相的不连续相; 不连续相均匀分散在连续相中，不连续相的粒径为0.1-2μm; 增塑剂中的成膜材料的量为0.1-100g / L; 核心材料由在38-100℃下经历液相 - 气相转变的液体组成，增强剂中核心材料的量为5-200ml / L。 本发明的用于HIFU处理的碳氟化合物乳液增强剂可以显着改变目标位置的声学环境，并且可以在HIFU处理期间增加目标位置处的声能沉积。

公开(公告)号：US20080139973A1

公开(公告)日：2008-06-12

申请号：US11794931

申请日：2005-09-02

申请人： Zhibiao Wang ,  Faqi Li ,  Yanbing Xiao ,  Ziwen Xiao ,  Liping Liu ,  Zhilong Wang

发明人： Zhibiao Wang ,  Faqi Li ,  Yanbing Xiao ,  Ziwen Xiao ,  Liping Liu ,  Zhilong Wang

IPC分类号： A61N7/02

CPC分类号： A61K41/0033 ,  A61K9/0019 ,  A61K9/107 ,  A61K9/127 ,  A61K31/685

摘要： The present invention discloses a particle enhancement agent for high intensity focused ultrasound (HIFU) treatment, which can increase acoustic energy deposition at the target location during HIFU treatment. The enhancement agent comprises a discontinuous phase comprised of a core material encapsulated by a membrane-forming material and a continuous phase comprising of aqueous medium. The discontinuous phase is uniformly dispersed in the continuous phase and the particle size of the discontinuous phase ranges from 0.1-8 μm; the amount of the membrane-forming material in the enhancement agent is 0.1-100 g/L; the core material is comprised of a liquid that does not undergo a liquid-gas phase transition at 38-100° C., and the amount of core material in the enhancement agent is 5-200 g/L.

摘要翻译： 本发明公开了一种用于高强度聚焦超声（HIFU）处理的颗粒增强剂，其可以在HIFU处理期间增加目标位置处的声能沉积。 增强剂包括由膜形成材料包封的芯材料和包含水性介质的连续相组成的不连续相。 不连续相均匀分散在连续相中，不连续相的粒径为0.1-8μm; 增塑剂中的成膜材料的量为0.1-100g / L; 核心材料由在38-100℃不经历液 - 气相变的液体组成，增强剂中芯材的量为5-200g / L。

公开(公告)号：US20090117052A1

公开(公告)日：2009-05-07

申请号：US11794928

申请日：2005-08-30

申请人： Zhibiao Wang ,  Faqi Li ,  Yanbing Xiao ,  Ziwen Xiao ,  Liping Liu ,  Zhilong Wang

发明人： Zhibiao Wang ,  Faqi Li ,  Yanbing Xiao ,  Ziwen Xiao ,  Liping Liu ,  Zhilong Wang

IPC分类号： A61B8/00 ,  A61N7/00

CPC分类号： A61K41/0052 ,  A61K41/0028

摘要： The present invention discloses an enhancement agent for high intensity focused ultrasound (HIFU) treatment, which is administered to a patient before HIFU treatment and can reduce the level of EEF at the target location to be treated with HIFU. EEF is presented by the expression: EEF=ηPt/V (unit: J/mm3), and refers to the HIFU energy needed to effectively treat a tumor per unit volume of the tumor, wherein, η=0.7; P refers to the total acoustic power of HIFU source (unit: W); t refers to the total time of HIFU treatment (unit: s); V refers to the volume of HIFU-induced lesions (unit: mm3). If the amount of EEF at the target location before administration of the enhancement agent is defined as EEF(base) and the amount of EEF at the target location after administration of the enhancement agent is defined as EEF(measurement), the ratio between EEF(base) and EEF(measurement) is more than 1, preferably more than 2, and more preferably over 4. The use of the enhancement agent for HIFU treatment of the present invention makes it possible to treat deep-seated tumors. In addition, patients with hepatic tumors can be effectively treated without removal of ribs. Accordingly, the present invention discloses methods for increasing acoustic energy deposition at target location during HIFU treatment and screening the enhancement agents for HIFU treatment.

摘要翻译： 本发明公开了一种用于高强度聚焦超声（HIFU）治疗的增强剂，其在HIFU治疗之前施用于患者，并且可以降低用HIFU治疗的目标位置处的EEF水平。 EEF由以下表达式表示：EEF = etaPt / V（单位：J / mm 3），并且是指每单位体积肿瘤有效治疗肿瘤所需的HIFU能量，其中eta = 0.7; P指HIFU源的总声功率（单位：W）; t指HIFU治疗的总时间（单位：s）; V指HIFU诱导的病变体积（单位：mm3）。 如果将增强剂施用前的目标位置处的EEF量定义为EEF（碱基），并且将施用增效剂后的目标位置处的EEF的量定义为EEF（测定），则EEF 碱）和EEF（测量）大于1，优选大于2，更优选超过4.使用本发明的HIFU治疗用增强剂可以治疗深层肿瘤。 此外，肝脏肿瘤患者可以有效地治疗，无需排除肋骨。 因此，本发明公开了在HIFU处理期间增加目标位置处的声能沉积并筛选用于HIFU处理的增强剂的方法。

公开(公告)号：US20080260790A1

公开(公告)日：2008-10-23

申请号：US11794927

申请日：2005-08-30

申请人： Zhibiao Wang ,  Faqi Li ,  Liping Liu ,  Yanbing Xiao ,  Ziwen Xiao ,  Zhilong Wang

发明人： Zhibiao Wang ,  Faqi Li ,  Liping Liu ,  Yanbing Xiao ,  Ziwen Xiao ,  Zhilong Wang

IPC分类号： A61K9/50 ,  A61K33/42 ,  A61K33/10 ,  A61P35/00

CPC分类号： A61K33/10 ,  A61K31/575 ,  A61K31/66 ,  A61K33/42 ,  A61K41/0028 ,  A61K41/0052 ,  A61K45/06 ,  A61N7/02 ,  A61K2300/00

摘要： The present invention discloses a plasmid enhancement agent for high intensity focused ultrasound (HIFU) treatment, which can increase acoustic energy deposition at the target location during HIFU treatment. The enhancement agent comprises a nanometer-sized biocompatible solid. The present invention also discloses another plasmid enhancement agent for HIFU treatment, wherein, the enhancement agent comprises a discontinuous phase is comprised of a core material encapsulated by a membrane-forming material, and a continuous phase comprised of aqueous medium; the discontinuous phase is uniformly dispersed in the continuous phase and has a particle size ranging from 10-1000 nm; the amount of the membrane-forming material in the enhancement agent is 0.1-100g/L; and the core material comprises nanometer-sized biocompatible solid selected from the group consisting of magnetic biomaterials, hydroxylapatite, and calcium carbonate, and the amount of the core material in the enhancement agent is 0.1-150 g/L.

摘要翻译： 本发明公开了一种用于高强度聚焦超声（HIFU）处理的质粒增强剂，其可以在HIFU处理期间增加目标位置处的声能沉积。 增强剂包括纳米尺寸的生物相容性固体。 本发明还公开了另一种用于HIFU处理的质粒增强剂，其中增强剂包括不连续相，其包含由成膜材料包封的芯材料和由水性介质组成的连续相; 不连续相均匀分散在连续相中，粒径范围为10-1000nm; 增塑剂中的成膜材料的量为0.1-100g / L; 并且核心材料包括选自磁性生物材料，羟基磷灰石和碳酸钙的纳米尺寸的生物相容性固体，并且增强剂中的芯材料的量为0.1-150g / L。

公开(公告)号：US20080287835A1

公开(公告)日：2008-11-20

申请号：US11794929

申请日：2005-09-02

申请人： Chunliang Zhao ,  Zhibiao Wang ,  Zhilong Wang ,  Jin Bai

发明人： Chunliang Zhao ,  Zhibiao Wang ,  Zhilong Wang ,  Jin Bai

IPC分类号： A61N7/00

CPC分类号： A61N7/00

摘要： The present invention is to provide an integrated ultrasound therapy transducer. It includes a piezoelectric transducer to generate therapy ultrasound, a support to support the piezoelectric transducer, a power amplifying module to drive the piezoelectric transducer. Wherein both the power amplifying module and the piezoelectric transducer are installed within the enclosure of the therapy transducer. The advantages of the integrated ultrasound therapy transducer assembly of the present invention include minimizing ultrasound therapy equipment and to decrease its volume and weight; reducing the electromagnetic interference and radiation greatly; and realizing the consistent performances of the ultrasound therapy equipments in mass productions and making the ultrasound therapy equipments have interchangeability.

摘要翻译： 本发明是提供一种整合的超声治疗换能器。 它包括用于产生治疗超声的压电换能器，支撑压电换能器的支撑件，用于驱动压电换能器的功率放大模块。 其中功率放大模块和压电换能器都安装在治疗传感器的外壳内。 本发明的一体化超声治疗换能器组件的优点包括使超声治疗设备最小化并减小体积和重量; 大大降低电磁干扰和辐射; 实现超声波治疗设备在大规模生产中的一贯表现，使超声治疗设备具有互换性。

公开(公告)号：US20080281252A1

公开(公告)日：2008-11-13

申请号：US11883080

申请日：2005-08-31

申请人： Zhilong Wang ,  Zhibiao Wang ,  Jin Bai ,  Zhengai Xiong

发明人： Zhilong Wang ,  Zhibiao Wang ,  Jin Bai ,  Zhengai Xiong

IPC分类号： A61M5/00

CPC分类号： A61M31/00 ,  A61B1/32 ,  A61M29/00

摘要： The present invention generally relates to a medical apparatus. More particularly, the present invention relates to an apparatus for delivering a medium to body cavity of mammals including a human, especially to an apparatus for expanding rectum. Specifically, the present invention relates to the field of focused ultrasound treatment with a main purpose to provide an auxiliary device for ultrasound therapy applied to uterine myoma so as to avoid damage by ultrasound after focused within body. Therefore, the present invention provides an apparatus for blocking ultrasound, comprising (1) lead-in means for entering into said body cavity; and (2) accommodation means for containing ultrasound blocking medium, which enwraps the lead-in means outside.

摘要翻译： 本发明一般涉及一种医疗装置。 更具体地，本发明涉及一种用于将包括人的哺乳动物的介质输送到体腔的装置，特别涉及用于扩张直肠的装置。 具体而言，本发明涉及聚焦超声处理领域，其主要目的是提供一种应用于子宫肌瘤的超声治疗辅助装置，以避免超声在体内聚焦后的损伤。 因此，本发明提供一种用于阻挡超声波的装置，包括：（1）用于进入所述体腔的引入装置; 和（2）用于容纳超声阻挡介质的容纳装置，其将导入装置包裹在外部。

公开(公告)号：US20090054772A1

公开(公告)日：2009-02-26

申请号：US11883097

申请日：2005-08-26

申请人： Tao Lin ,  Wenzhi Chen ,  Yingang Wen ,  Zhibiao Wang ,  Zhilong Wang

发明人： Tao Lin ,  Wenzhi Chen ,  Yingang Wen ,  Zhibiao Wang ,  Zhilong Wang

IPC分类号： A61B8/00 ,  A61N7/00

CPC分类号： A61N7/02 ,  A61B90/14 ,  A61B2090/378

摘要： The present invention pertains to an ultrasound therapy system and more specifically, to a high-intensity focused ultrasound (HIFU) therapy apparatus guided by image registration and fusion method. The therapy system of the present invention comprises a central control means; an acoustic energy applicator; a mechanical driving and locating means of said acoustic energy applicator; a real-time B-mode ultrasound image guiding device. Further the therapy system of the present invention comprises an immobilization means for body position. By the help of this immobilization means for body position, real-time B-mode ultrasound images can be registered with diagnosis images, and then on the basis of registration, said B-mode ultrasound images are fused with said diagnosis images for guiding said therapy. Comparing to the existed technical solutions in this field, the present invention has effectively solved the difficult problems in high-intensity focused ultrasound therapy and particularly for tumor treatment with a low cost. And it provides a very practical technical solution, which can be easily applied to clinical treatment of tumors.

摘要翻译： 本发明涉及一种超声治疗系统，更具体地涉及由图像配准和融合方法引导的高强度聚焦超声（HIFU）治疗装置。 本发明的治疗系统包括中央控制装置; 声能施加器; 所述声能施加器的机械驱动和定位装置; 实时B模式超声图像引导装置。 此外，本发明的治疗系统包括用于身体位置的固定装置。 借助于该身体位置的固定装置，实时B模式超声图像可以与诊断图像一起登记，然后在登记的基础上，将所述B模式超声图像与用于引导所述治疗的所述诊断图像融合 。 与现有技术方案相比，本发明有效地解决了高强度聚焦超声治疗中的困难问题，特别是低成本的肿瘤治疗。 它提供了一个非常实用的技术解决方案，可以很容易地应用于肿瘤的临床治疗。

公开(公告)号：US20050080359A1

公开(公告)日：2005-04-14

申请号：US10499341

申请日：2002-12-16

申请人： Chunliang Zhao ,  Zhibiao Wang ,  Zhilong Wang ,  Fangwei Ye

发明人： Chunliang Zhao ,  Zhibiao Wang ,  Zhilong Wang ,  Fangwei Ye

IPC分类号： A61B18/00 ,  A61N7/02 ,  A61N7/00

CPC分类号： A61N7/02 ,  A61B2018/00023

摘要： The invention provides an ultrasound therapeutic apparatus for treating skin lesions of human being, comprising a controlling device, an ultrasound transducer transmitting the therapeutic ultrasound beam to the subject, a focusing means. Said controlling device is the electrical control system of the ultrasound therapeutic apparatus. Said ultrasound transducer and said focusing means are placed in an ultrasound applicator, which can be held by hand. The ultrasound applicator, which can be held by hand, includes a handle and a housing forming a lumen and the said ultrasound transducer and said focusing means are placed in the said lumen. The ultrasound applicator can be held by clinicians' hand, performing a treatment on skin lesions of human being including the skin lesions of gynecology more conveniently.

摘要翻译： 本发明提供一种用于治疗人的皮肤损伤的超声治疗装置，包括控制装置，将治疗性超声波束传送到对象的超声波换能器，聚焦装置。 所述控制装置是超声治疗装置的电气控制系统。 所述超声波换能器和所述聚焦装置放置在可由手持的超声波施加器中。 可以手持的超声波施加器包括手柄和形成内腔的壳体，并且所述超声波换能器和所述聚焦装置被放置在所述内腔中。 超声波治疗仪可由临床医生掌握，更方便地对包括妇科皮肤病变在内的人体皮肤病变进行治疗。

公开(公告)号：US08251929B2

公开(公告)日：2012-08-28

申请号：US11794929

申请日：2005-09-02

申请人： Chunliang Zhao ,  Zhibiao Wang ,  Zhilong Wang ,  Jin Bai

发明人： Chunliang Zhao ,  Zhibiao Wang ,  Zhilong Wang ,  Jin Bai

IPC分类号： A61N7/00

CPC分类号： A61N7/00

摘要： The present invention is to provide an integrated ultrasound therapy transducer. It includes a piezoelectric transducer to generate therapy ultrasound, a support to support the piezoelectric transducer, a power amplifying module to drive the piezoelectric transducer. Wherein both the power amplifying module and the piezoelectric transducer are installed within the enclosure of the therapy transducer. The advantages of the integrated ultrasound therapy transducer assembly of the present invention include minimizing ultrasound therapy equipment and to decrease its volume and weight; reducing the electromagnetic interference and radiation greatly; and realizing the consistent performances of the ultrasound therapy equipments in mass productions and making the ultrasound therapy equipments have interchangeability.

摘要翻译： 本发明是提供一种整合的超声治疗换能器。 它包括用于产生治疗超声的压电换能器，支撑压电换能器的支撑件，用于驱动压电换能器的功率放大模块。 其中功率放大模块和压电换能器都安装在治疗传感器的外壳内。 本发明的一体化超声治疗换能器组件的优点包括使超声治疗设备最小化并减小体积和重量; 大大降低电磁干扰和辐射; 实现超声波治疗设备在大规模生产中的一贯表现，使超声治疗设备具有互换性。

公开(公告)号：US20080188745A1

公开(公告)日：2008-08-07

申请号：US11794930

申请日：2005-08-02

申请人： Wenzhi Chen ,  Zhibiao Wang ,  Zhilong Wang ,  Tao Lin ,  Chunliang Zhao

发明人： Wenzhi Chen ,  Zhibiao Wang ,  Zhilong Wang ,  Tao Lin ,  Chunliang Zhao

IPC分类号： A61N7/00

CPC分类号： A61N7/02 ,  A61B2090/378

摘要： The apparatus for high-intensity focused ultrasound therapy of the present invention usually comprises a ultrasound transducer, an image acquisition device, a driving unit for driving said ultrasound transducer and mechanical drive means for mechanically driving said ultrasound transducer and image acquisition device together. Additionally, this apparatus for high-intensity focused ultrasound therapy further comprises a signal processing unit connected to image acquisition device for receiving and saving the original images of the target area prior to treatment and for receiving and saving the images of the target area in a certain time during high-intensity focused ultrasound (HIFU) treatment and for evaluating the therapeutic effects according to the images of the target area before and after treatment, and a control unit respectively connected to signal processing unit, driving unit and mechanical driving means. When the signal processing unit judges that the therapeutic requirements have been met, the control unit controls the driving unit and mechanical driving means to stop the working of ultrasound transducer and when the signal processing unit judges that the therapeutic requirements have not been met, the control unit controls the driving unit and mechanical driving means to make the ultrasound transducer continue to work.

摘要翻译： 本发明的高强度聚焦超声治疗装置通常包括超声波换能器，图像采集装置，用于驱动所述超声波换能器的驱动单元和用于将所述超声换能器和图像采集装置机械驱动在一起的机械驱动装置。 此外，该高强度聚焦超声治疗装置还包括连接到图像获取装置的信号处理单元，用于在处理之前接收和保存目标区域的原始图像，并且在一定程度上接收和保存目标区域的图像 在高强度聚焦超声（HIFU）治疗期间的时间和根据治疗前后的目标区域的图像来评估治疗效果的时间，以及分别连接到信号处理单元，驱动单元和机械驱动装置的控制单元。 当信号处理单元判断满足治疗要求时，控制单元控制驱动单元和机械驱动装置来停止超声波换能器的工作，并且当信号处理单元判断出没有满足治疗要求时，控制 单元控制驱动单元和机械驱动装置，以使超声换能器继续工作。