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    Method of altering nutritional components of milk produced by a lactating animal
    3.
    发明授权
    Method of altering nutritional components of milk produced by a lactating animal 失效
    改变哺乳动物产生的牛奶的营养成分的方法

    公开(公告)号：US06288114B1

    公开(公告)日：2001-09-11

    申请号：US09103366

    申请日：1998-06-23

    申请人： Dale E. Bauman ,  Mark A. McGuire ,  Mikko Griinari ,  P. Yvan Chouinard

    发明人： Dale E. Bauman ,  Mark A. McGuire ,  Mikko Griinari ,  P. Yvan Chouinard

    IPC分类号： A61K31202

    CPC分类号： A61K31/201 ,  A23C9/1528 ,  A23C2230/10 ,  A23V2002/00 ,  A61K31/202 ,  A23V2200/308 ,  A23V2250/1866

    摘要： The present invention alters mammary synthesis of fat to improve milk quality. These changes in milk composition represent improvements in nutritional quality consistent with contemporary dietary recommendations. Of special importance is the disclosure of new data relating to specific conjugated linoleic acids (CLA), potent naturally occurring anti-carcinogens. In the course of an investigation to enhance milk content of conjugated linoleic acid, it was discovered that abomasal infusion of a single TFA isomer caused a marked milk fat depression. This observation was unexpected because the prior art has consistently shown that body fat and milk fat always show reciprocal changes in lactating cows and indicated that CLA's generally reduced body fat in growing animals. The current disclosure demonstrates that an increase in milk fat content of a specific TFA isomer, trans-10 C18:1. (Griinari et al., 1997, 1998) causes MFD. This observation is in conflict with the prior art that taught that an increase in total TFA caused MFD. These results are applicable to other domestic lactating mammals (e.g., pigs). Upon the infusion of CLA, a portion of the CLA is transferred to the mammary gland and incorporated into milk fat. Hence, the methods disclosed increase the levels of CLA found in milk, thereby improving the nutritional benefits to human health associated with CLA.

    摘要翻译： 本发明改变乳脂肪的合成以提高乳品质量。 牛奶组合中的这些变化代表了与当代饮食建议一致的营养质量的改善。 特别重要的是披露与特定共轭亚油酸（CLA）有关的天然存在的抗致癌物质的新数据。 在研究提高共轭亚油酸的牛奶含量的过程中，发现单次TFA异构体的腹腔输注导致明显的乳脂肪抑制。 这种观察是意想不到的，因为现有技术一直表明，身体脂肪和乳脂肪总是显示哺乳牛的相互变化，并且表明CLA通常在生长的动物中降低身体脂肪。 目前的公开内容表明，特定TFA异构体，反式-10 C18：1的乳脂肪含量增加。 （Griinari等，1997，1998）导致MFD。 这一观察结果与现有技术相冲突，该技术教导了总TFA的增加引起MFD。 这些结果适用于其他国内哺乳哺乳动物（如猪）。 在输注CLA时，将CLA的一部分转移到乳腺并且并入乳脂中。 因此，所公开的方法增加了在牛奶中发现的CLA水平，从而改善了与CLA相关的人体健康的营养益处。

    Use of growth hormone to enhance porcine weight gain
    5.
    发明授权
    Use of growth hormone to enhance porcine weight gain 失效
    使用生长激素来增加猪的体重增加

    公开(公告)号：US5134120A

    公开(公告)日：1992-07-28

    申请号：US333878

    申请日：1989-04-04

    申请人： R. Dean Boyd ,  Dale E. Bauman ,  Walter R. Butler

    发明人： R. Dean Boyd ,  Dale E. Bauman ,  Walter R. Butler

    IPC分类号： A61K38/25 ,  A61K38/27

    CPC分类号： A61K38/25 ,  A61K38/27

    摘要： This invention relates to deliberately increasing growth hormone in swine during the last 2 weeks of pregnancy through a 3 week lactation. This has the effect of increasing fetal energy storage during late pregnancy which resulted in the newborn piglets having marked enhancement of the ability to maintain plasma concentrations of glucose and free fatty acids when fasted after birth. Likewise, treatment of the sow during lactation results in increased milkfat in the colostrum and an increased milk yield. These effects are important in enhancing survivability of newborn pigs and weight gain prior to weaning.

    摘要翻译： 本发明涉及通过3周哺乳期间在怀孕的最后2周期间有意增加猪中的生长激素。 这具有在晚期怀孕期间增加胎儿能量储存的作用，这导致新生仔猪在出生后禁食时维持葡萄糖和游离脂肪酸的血浆浓度的显着增强。 同样地，哺乳期母猪的处理会导致初乳中的乳脂增加，而且产奶量增加。 这些影响对于提高新生猪的生存能力和断奶前的体重增加很重要。

    Use of growth hormone to enhance porcine fetal energy and sow lactation performance
    7.
    发明授权
    Use of growth hormone to enhance porcine fetal energy and sow lactation performance 失效
    使用生长激素来增强猪胎儿的能量并播种泌乳性能

    公开(公告)号：US5292721A

    公开(公告)日：1994-03-08

    申请号：US864391

    申请日：1992-04-06

    申请人： R. Dean Boyd ,  Dale E. Bauman ,  Walter R. Butler

    发明人： R. Dean Boyd ,  Dale E. Bauman ,  Walter R. Butler

    IPC分类号： A61K38/25 ,  A61K38/27 ,  A61K37/02

    CPC分类号： A61K38/25 ,  A61K38/27

    摘要： This invention relates to deliberately increasing growth hormone in swine during the last 2 weeks of pregnancy through a 3 week lactation. This has the effect of increasing fetal energy storage during late pregnancy which resulted in the newborn piglets having marked enhancement of the ability to maintain plasma concentrations of glucose and free fatty acids when fasted after birth. Likewise, treatment of the sow during lactation results in increased milkfat in the colostrum and an increased milk yield. These effects are important in enhancing survivability of newborn pigs and weight gain prior to weaning.

    摘要翻译： 本发明涉及通过3周哺乳期间在怀孕的最后2周期间有意增加猪中的生长激素。 这具有在晚期怀孕期间增加胎儿能量储存的作用，这导致新生仔猪在出生后禁食时维持葡萄糖和游离脂肪酸的血浆浓度的显着增强。 同样地，哺乳期母猪的处理会导致初乳中的乳脂增加，而且产奶量增加。 这些影响对于提高新生猪的生存能力和断奶前的体重增加很重要。

    Induction of lactation in nonpregnant dairy animals
    8.
    发明授权
    Induction of lactation in nonpregnant dairy animals 失效
    诱导非妊娠乳牛的哺乳期

    公开(公告)号：US4060620A

    公开(公告)日：1977-11-29

    申请号：US687205

    申请日：1976-05-17

    申请人： Dale E. Bauman ,  Robert J. Collier ,  Ray L. Hays

    发明人： Dale E. Bauman ,  Robert J. Collier ,  Ray L. Hays

    IPC分类号： A61K31/475

    CPC分类号： A61K31/475

    摘要： The administration of reserpine to nonlactating dairy cattle produces a marked increase in circulating serum prolactin levels. The parenteral administration of reserpine to nonlactating cows which have been hormonally induced into lactation, as by the parenteral administration of an estrogen and progesterone, and dexamethasone, results in a substantial rise in milk production.

    摘要翻译： 利血平对非乳酸奶牛的施用导致循环血清催乳素水平显着增加。 通过胃肠外施用雌激素和孕激素以及地塞米松将利血平肠胃外给予已激素诱导为哺乳期的非激素奶牛，导致产奶量大幅度上升。