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![Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors](/abs-image/US/2006/06/29/US20060142331A1/abs.jpg.150x150.jpg)
1.发明申请Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 有权新型8-氮杂 - 双环[3.2.1]辛烷衍生物及其作为单胺神经递质再摄取抑制剂的用途公开(公告)号：US20060142331A1
公开(公告)日：2006-06-29
申请号：US10561417
申请日：2004-06-18
IPC分类号： C07D451/06 , A61K31/46
CPC分类号： C07D451/04 , C07D451/06
摘要： This invention relates to novel 8-aza-bicyclo[3.2.1]octane derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型8-氮杂 - 双环[3.2.1]辛烷衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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2.发明申请Novel alkyl substituted piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 失效新型烷基取代的哌啶衍生物及其作为单胺神经递质再摄取抑制剂的用途公开(公告)号：US20070167487A1
公开(公告)日：2007-07-19
申请号：US11579060
申请日：2005-06-14
IPC分类号： A61K31/445 , C07D211/06 , C07D211/54
CPC分类号： C07D211/42 , C07D211/46 , C07D211/54 , C07D211/58
摘要： This invention relates to novel alkyl substituted piperidine derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型烷基取代的哌啶衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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![3,8-Substituted 8-Aza-Bicyclo[3.2.1]Octane Derivatives and Their Use as Monomine Neurotransmitter Re-Uptake Inhibitors](/abs-image/US/2008/01/03/US20080004252A1/abs.jpg.150x150.jpg)
3.发明申请3,8-Substituted 8-Aza-Bicyclo[3.2.1]Octane Derivatives and Their Use as Monomine Neurotransmitter Re-Uptake Inhibitors 失效3,8-取代的8-氮杂 - 双环[3.2.1]辛烷衍生物及其作为单体神经递质重吸收抑制剂的用途公开(公告)号：US20080004252A1
公开(公告)日：2008-01-03
申请号：US11794365
申请日：2006-01-11
申请人： Dan Peters , Bjarne Dahl , Gunnar Olsen , Elsebet Nielsen , Jorgen Scheel-Kruger , John Redrobe
发明人： Dan Peters , Bjarne Dahl , Gunnar Olsen , Elsebet Nielsen , Jorgen Scheel-Kruger , John Redrobe
IPC分类号： A61K31/397 , A61P25/00 , C07D205/00
CPC分类号： C07D451/06
摘要： This invention relates to novel 8-aza-bicyclo[3.2.1]octane derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型8-氮杂 - 双环[3.2.1]辛烷衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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4.发明申请Novel Chromen-2-One Derivatives and Their Use as Monoamine Neurotransmitter Re-Uptake Inhibitors 有权新型色素-2-酮衍生物及其用作单胺神经递质重吸收抑制剂公开(公告)号：US20070232666A1
公开(公告)日：2007-10-04
申请号：US11661966
申请日：2005-09-28
IPC分类号： C07D451/06 , A61K31/137
CPC分类号： C07D405/12 , C07D451/06 , C07D451/12
摘要： This invention relates to novel chromen-2-one derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型色烯-2-酮衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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5.发明申请Novel Alkyl Substituted Piperidine Derivatives as Monoamine Neurotransmitter Re-Uptake Inhibitors 审中-公开新型烷基取代的哌啶衍生物作为单胺神经递质重吸收抑制剂公开(公告)号：US20070232659A1
公开(公告)日：2007-10-04
申请号：US11579059
申请日：2005-06-14
IPC分类号： A61K31/454 , A61P15/00 , A61P25/00 , C07D401/06
CPC分类号： C07D401/12 , C07D401/04 , C07D409/12 , C07D413/12 , C07D417/12
摘要： This invention relates to novel alkyl substituted piperidine derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型烷基取代的哌啶衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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![Novel 9-Aza-Bicyclo[3.3.1]Nonane Derivatives and Their Use as Monoamine Neurotransmitter Re-Uptake Inhibitors](/abs-image/US/2007/10/04/US20070232641A1/abs.jpg.150x150.jpg)
6.发明申请Novel 9-Aza-Bicyclo[3.3.1]Nonane Derivatives and Their Use as Monoamine Neurotransmitter Re-Uptake Inhibitors 失效新型9-氮杂双环[3.3.1]壬烷衍生物及其作为单胺神经递质重吸收抑制剂的用途公开(公告)号：US20070232641A1
公开(公告)日：2007-10-04
申请号：US11579056
申请日：2005-06-14
IPC分类号： C07D451/14 , A61K31/439 , A61P23/00
CPC分类号： C07D451/14
摘要： This invention relates to novel 9-aza-bicyclo[3.3.1]nonane derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型9-氮杂 - 双环[3.3.1]壬烷衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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![Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors](/abs-image/US/2006/07/06/US20060148847A1/abs.jpg.150x150.jpg)
7.发明申请Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 失效新型8-氮杂 - 双环[3.2.1]辛烷衍生物及其作为单胺神经递质再摄取抑制剂的用途公开(公告)号：US20060148847A1
公开(公告)日：2006-07-06
申请号：US10543828
申请日：2004-02-10
IPC分类号： A61K31/46 , C07D451/02
CPC分类号： C07D451/02
摘要： This invention relates to novel 8-aza-bicyclo[[3.2.1]octane derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型8-氮杂 - 双环[[3.2.1]辛烷衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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8.发明申请8-Aza-Bicyclo (3.2.1) octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 失效8-氮杂 - 双环（3.2.1）辛烷衍生物及其作为单胺神经递质再摄取抑制剂的用途公开(公告)号：US20060122218A1
公开(公告)日：2006-06-08
申请号：US10544027
申请日：2004-02-10
IPC分类号： A61K31/46 , C07D451/02
CPC分类号： C07D451/02
摘要： This invention relates to novel 8-aza-bicyclop[3.2.1]octane derivatives useful as monoamine neurotransmitter re-up-take inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型8-氮杂 - 双环[3.2.1]辛烷衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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9.发明申请公开(公告)号：US20060122172A1
公开(公告)日：2006-06-08
申请号：US10528361
申请日：2003-09-29
申请人： Dan Peters , Gunnar Olsen , Elsebet Nielsen , Tino Jorgensen , Philip Ahring
发明人： Dan Peters , Gunnar Olsen , Elsebet Nielsen , Tino Jorgensen , Philip Ahring
IPC分类号： C07D487/04 , A61K31/551
CPC分类号： C07D471/08 , C07D487/04
摘要： This invention relates to novel 1,4-diazabicycloalkane derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
摘要翻译： 本发明涉及新的1,4-二氮杂双环链烷烃衍生物及其在制备药物组合物中的用途。 发现本发明的化合物是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。
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公开(公告)号：US20060100192A1
公开(公告)日：2006-05-11
申请号：US11312574
申请日：2005-12-21
申请人： Simon Nielsen , Dan Peters , Elsebet Nielsen , Gunnar Olsen
发明人： Simon Nielsen , Dan Peters , Elsebet Nielsen , Gunnar Olsen
IPC分类号： A61K31/551 , C07D403/02
CPC分类号： C07D401/14 , C07D401/04 , C07D403/04 , C07D405/14 , C07D417/04
摘要： The present invention relates to novel heteroaryl diazacycloalkane derivatives, which are found to be cholinergic ligands at the nicotinic Acetyl Choline Receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neurodegeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
摘要翻译： 本发明涉及新颖的杂芳基二氮杂环烷烃衍生物，其在烟碱乙酰胆碱受体中被发现是胆碱能配体。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS）的胆碱能系统有关的疾病或病症，与平滑肌收缩相关的疾病或病症，内分泌疾病或 与神经变性相关的疾病，疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。
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