-
公开(公告)号：US20200216454A1
公开(公告)日：2020-07-09
申请号：US16066149
申请日：2016-12-29
发明人： Nathanael S. GRAY , James BRADNER , Pasi JANNE , Jaebong JANG , Dennis BUCKLEY , Dennis DOBROVOLSKY
IPC分类号： C07D487/04
摘要： The invention provides bifunctional compounds which act as protein degradation inducing moieties for a HER family protein, such as Her3. The invention also provides methods for the targeted degradation of a HER family protein through the use of the bifunctional compounds that link a ubiquitin ligase-binding moiety to a ligand that is capable of binding to the HER family protein which can be utilized in the treatment of disorders modulated by a HER family protein.
-
公开(公告)号：US20190194169A1
公开(公告)日：2019-06-27
申请号：US16290153
申请日：2019-03-01
发明人： Nathanael S. GRAY , Pasi JANNE , Hwan Geun CHOI , Jaebong JANG
IPC分类号： C07D403/04 , C07D487/04 , C07D471/04 , C07D403/14
CPC分类号： C07D403/04 , C07D403/14 , C07D471/04 , C07D487/04
摘要： The application relates to a compound having Formula (I): which modulates the activity of EGFR, a pharmaceutical composition comprising the compound, and a method of treating or preventing a disease in which EGFR plays a role.
-
公开(公告)号：US20180290975A1
公开(公告)日：2018-10-11
申请号：US15580088
申请日：2016-06-30
发明人： Nathanael S. GRAY , Michael ECK , Pasi JANNE , Hwan Geun CHOI , Jaebong JANG , Kwok-Kin WONG
IPC分类号： C07D209/46 , C07D417/12 , C07D401/12 , C07D413/12 , C07D417/14 , C07D403/12 , C07D513/04 , C07D487/04 , C07D277/46 , C07D413/14 , C07D403/14 , C07D471/04
CPC分类号： C07D209/46 , A61P35/00 , C07D277/46 , C07D401/12 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The disclosure relates to a compound having Formula (I′): and in particular, Compound I-126: which modulates the activity of EGFR, a pharmaceutical composition comprising the compound, and a method of treating or preventing a disease in which EGFR plays a role.
-
公开(公告)号：US20170362204A1
公开(公告)日：2017-12-21
申请号：US15536486
申请日：2015-12-23
发明人： Nathanael S. GRAY , Pasi JANNE , Hwan Geun CHOI , Jaebong JANG
IPC分类号： C07D403/04 , C07D403/14 , C07D471/04 , C07D487/04
CPC分类号： C07D403/04 , C07D403/14 , C07D471/04 , C07D487/04
摘要： The application relates to a compound having Formula (I): which modulates the activity of EGFR, a pharmaceutical composition comprising the compound, and a method of treating or preventing a disease in which EGFR plays a role.
-
公开(公告)号：US20210094913A1
公开(公告)日：2021-04-01
申请号：US17035164
申请日：2020-09-28
发明人： Nathanael S. GRAY , Michael ECK , Pasi JANNE , Hwan Geun CHOI , Jaebong JANG , Kwok-Kin WONG
IPC分类号： C07D209/46 , C07D401/12 , C07D417/12 , C07D417/14 , C07D403/12 , C07D413/14 , C07D403/14 , C07D413/12 , C07D471/04 , C07D487/04 , C07D277/46 , C07D513/04 , A61P35/00
摘要： The disclosure relates to a compound having Formula (I′): and in particular, Compound I-126: which modulates the activity of EGFR, a pharmaceutical composition comprising the compound, and a method of treating or preventing a disease in which EGFR plays a role.
-
公开(公告)号：US20200002279A1
公开(公告)日：2020-01-02
申请号：US16440803
申请日：2019-06-13
发明人： Nathanael S. GRAY , Michael ECK , Pasi JANNE , Hwan Geun CHOI , Jaebong JANG , Kwok-Kin WONG
IPC分类号： C07D209/46 , A61P35/00 , C07D277/46 , C07D401/12 , C07D403/12 , C07D403/14 , C07D513/04 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D413/12
摘要： The disclosure relates to a compound having Formula (I′): and in particular, Compound I-126: which modulates the activity of EGFR, a pharmaceutical composition comprising the compound, and a method of treating or preventing a disease in which EGFR plays a role.
-
公开(公告)号：US20180194758A1
公开(公告)日：2018-07-12
申请号：US15742113
申请日：2016-07-20
发明人： Nathanael S. GRAY , Jaebong JANG , Pasi JANNE
IPC分类号： C07D413/14 , C07D409/14 , C07D403/14 , C07D403/12 , C07D401/14 , A61P31/12
CPC分类号： C07D413/14 , A61P31/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/14
摘要： The application relates to a compound having Formula (I′): which modulates the activity of EGFR, a pharmaceutical composition comprising the compound, and a method of treating or preventing a disease in which EGFR plays a role.
-
公开(公告)号：US20210078977A1
公开(公告)日：2021-03-18
申请号：US16950465
申请日：2020-11-17
发明人： Nathanael S. GRAY , Pasi JANNE , Hwan Geun CHOI , Jaebong JANG
IPC分类号： C07D403/04 , C07D471/04 , C07D403/14 , C07D487/04
摘要： The application relates to a compound having Formula (I): which modulates the activity of EGFR, a pharmaceutical composition comprising the compound, and a method of treating or preventing a disease in which EGFR plays a role.
-
![6,11-DIHYDRO-5H-BENZO[B]CARBAZOLE INHIBITORS OF ALK AND SRPK AND METHODS OF USE](/abs-image/US/2020/07/16/US20200223798A1/abs.jpg.150x150.jpg)
公开(公告)号：US20200223798A1
公开(公告)日：2020-07-16
申请号：US16668484
申请日：2019-10-30
发明人： John HATCHER , Nathanael S. GRAY , Hwan Geun CHOI , Pasi JANNE , Tinghu ZHANG
IPC分类号： C07D209/80 , C07D401/14 , C07D405/14 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , A61P35/00 , C12N9/12 , C12N9/96
摘要： The application relates to a compound of Formula (I): which modulates the activity of ALK or SRPK, a pharmaceutical composition comprising the compound, and a method of treating or preventing a disease in which ALK or SRPK plays a role.
-
公开(公告)号：US20190016703A1
公开(公告)日：2019-01-17
申请号：US16066150
申请日：2016-12-29
发明人： Nathanael S. GRAY , James BRADNER , Pasi JANNE , Jaebong JANG , Hwan Geun CHOI , Eunhwa KO , Joong-Heui CHO
IPC分类号： C07D401/14 , A61P35/00 , A61K47/54 , A61K47/18 , A61K47/08
摘要： The present invention provides bifunctional compounds which act as protein degradation inducing moieties for a HER family protein, such as Her3. The present invention also provides methods for the targeted degradation of a HER family protein through the use of the bifunctional compounds that link a ubiquitin ligase-binding moiety to a ligand that is capable of binding to the HER family protein which can be utilized in the treatment of disorders modulated by a HER family protein.
-
-
-
-
-
-
-
-
-
搜索结果
11 条记录 (耗时 0.022 秒)
