公开(公告)号：US20060018949A1

公开(公告)日：2006-01-26

申请号：US11079872

申请日：2005-03-14

申请人： Daniel Ammon ,  Joseph Salamone ,  Hiroki Ueda ,  Seongbong Jo ,  Antonios Mikos

发明人： Daniel Ammon ,  Joseph Salamone ,  Hiroki Ueda ,  Seongbong Jo ,  Antonios Mikos

IPC分类号： A61F2/00

CPC分类号： A61K9/1635 ,  A61K9/0051 ,  A61K9/1647 ,  A61K47/32 ,  A61K47/34

摘要： Compositions for delivering a pharmaceutically active agent to the eye, and/or for treating an ophthalmic disorder, are based on a fumarate polymer, especially a poly(propylene fumarate) polymer.

摘要翻译： 将药物活性剂递送至眼睛和/或用于治疗眼科疾病的组合物基于富马酸酯聚合物，特别是聚（富马酸丙二醇酯）聚合物。

公开(公告)号：US20090291106A1

公开(公告)日：2009-11-26

申请号：US12505449

申请日：2009-07-17

申请人： Achim Göpferich ,  Jörg Tessmar ,  Michaela Schulz ,  Torsten Blunk ,  Antonios Mikos

发明人： Achim Göpferich ,  Jörg Tessmar ,  Michaela Schulz ,  Torsten Blunk ,  Antonios Mikos

IPC分类号： A61K9/00 ,  C12N5/06 ,  C07K1/04 ,  C40B40/14

CPC分类号： C12N5/0068 ,  A61K9/1676 ,  A61K47/593 ,  A61K47/60 ,  C08G63/664 ,  C08L71/02 ,  C12N2533/40 ,  C08L2666/18

摘要： A block copolymer containing a) a hydrophobic biodegradable polymer, b) a hydrophilic polymer and c) at least one reactive group for covalent binding of a surface-modifying substance d) to the hydrophilic polymer b) is disclosed. Shaped bodies are formed to consist of the block copolymer and are utilized as carriers for tissue culture and active substances and for controlled release and targeted administration of active substances.

摘要翻译： 含有a）疏水性生物可降解聚合物的嵌段共聚物，b）亲水性聚合物和c）至少一种用于表面改性物质d）与亲水性聚合物b）共价结合的反应性基团。 成型体形成为由嵌段共聚物组成，并用作组织培养和活性物质的载体并用于活性物质的控制释放和靶向施用。

公开(公告)号：US20070299227A1

公开(公告)日：2007-12-27

申请号：US11897175

申请日：2007-08-28

申请人： Achim Gopferich ,  Jorg Tessmar ,  Michaela Schulz ,  Torsten Blunk ,  Antonios Mikos

发明人： Achim Gopferich ,  Jorg Tessmar ,  Michaela Schulz ,  Torsten Blunk ,  Antonios Mikos

IPC分类号： C08H1/00 ,  C07H15/04

CPC分类号： C12N5/0068 ,  A61K9/1676 ,  A61K47/593 ,  A61K47/60 ,  C08G63/664 ,  C08L71/02 ,  C12N2533/40 ,  C08L2666/18

摘要： The invention relates to a block copolymer containing: a) hydrophobic biodegradable polymer; b) a hydrophilic polymer and c) at least one reactive group for covalent binding of a surface-modifying substance d) to the hydrophilic polymer b). The invention relates to shaped bodies consisting of the block copolymer and to their utilization, particularly as carriers for tissue culture and active substances and for controlled release and targeted administration of active substances.

公开(公告)号：US20070299238A1

公开(公告)日：2007-12-27

申请号：US11897176

申请日：2007-08-28

申请人： Achim Gopferich ,  Jorg Tessmar ,  Michaela Schulz ,  Torsten Blunk ,  Antonios Mikos

发明人： Achim Gopferich ,  Jorg Tessmar ,  Michaela Schulz ,  Torsten Blunk ,  Antonios Mikos

IPC分类号： C08G69/08

CPC分类号： C12N5/0068 ,  A61K9/1676 ,  A61K47/593 ,  A61K47/60 ,  C08G63/664 ,  C08L71/02 ,  C12N2533/40 ,  C08L2666/18

摘要： The invention relates to a block copolymer containing: a) hydrophobic biodegradable polymer; b) a hydrophilic polymer and c) at least one reactive group for covalent binding of a surface-modifying substance d) to the hydrophilic polymer b). The invention relates to shaped bodies consisting of the block copolymer and to their utilization, particularly as carriers for tissue culture and active substances and for controlled release and targeted administration of active substances.

公开(公告)号：US20070299240A1

公开(公告)日：2007-12-27

申请号：US11897145

申请日：2007-08-28

申请人： Achim Gopferich ,  Jorg Tessmar ,  Michaela Schulz ,  Torsten Blunk ,  Antonios Mikos

发明人： Achim Gopferich ,  Jorg Tessmar ,  Michaela Schulz ,  Torsten Blunk ,  Antonios Mikos

IPC分类号： C08G63/06

CPC分类号： C12N5/0068 ,  A61K9/1676 ,  A61K47/593 ,  A61K47/60 ,  C08G63/664 ,  C08L71/02 ,  C12N2533/40 ,  C08L2666/18

摘要： The invention relates to a block copolymer containing: a) hydrophobic biodegradable polymer; b) a hydrophilic polymer and c) at least one reactive group for covalent binding of a surface-modifying substance d) to the hydrophilic polymer b). The invention relates to shaped bodies consisting of the block copolymer and to their utilization, particularly as carriers for tissue culture and active substances and for controlled release and targeted administration of active substances.

摘要翻译： 本发明涉及含有：a）疏水性生物可降解聚合物的嵌段共聚物; b）亲水性聚合物和c）至少一个用于表面改性物质d）与亲水性聚合物b）共价结合的反应性基团。 本发明涉及由嵌段共聚物组成的成型体及其利用，特别是作为组织培养和活性物质的载体，以及活性物质的控制释放和靶向施用。

公开(公告)号：US20060141000A1

公开(公告)日：2006-06-29

申请号：US10775768

申请日：2004-02-10

申请人： Antonios Mikos ,  Donald Ingber ,  Joseph Vacanti ,  Robert Langer

发明人： Antonios Mikos ,  Donald Ingber ,  Joseph Vacanti ,  Robert Langer

IPC分类号： A61K35/12

CPC分类号： G02B27/0031 ,  A61L27/18 ,  A61L27/56 ,  A61L2400/06 ,  G03F7/40 ,  H01L21/0273 ,  H01L21/32139 ,  C08L67/04

摘要： Polymeric materials are used to make a pliable, non-toxic, injectable porous template for vascular ingrowth. The pore size, usually between approximately 100 and 300 microns, allows vascular and connective tissue ingrowth throughout approximately 10 to 90% of the matrix following implantation, and the injection of cells uniformly throughout the implanted matrix without damage to the cells or patient. The introduced cells attach to the connective tissue within the matrix and are fed by the blood vessels. The preferred material for forming the matrix or support structure is a biocompatible synthetic polymer which degrades in a controlled manner by hydrolysis into harmless metabolites, for example, polyglycolic acid, polylactic acid, polyorthoester, polyanhydride, or copolymers thereof. The rate of tissue ingrowth increases as the porosity and/or the pore size of the implanted devices increases. The time required for the tissue to fill the device depends on the polymer crystallinity and is less for amorphous polymers versus semicrystalline polymers. The vascularity of the advancing tissue is consistent with time and independent of the biomaterial composition and morphology.