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    INTRALUMINAL POLYMERIC DEVICES FOR THE TREATMENT OF ANEURYSMS
    1.
    发明申请
    INTRALUMINAL POLYMERIC DEVICES FOR THE TREATMENT OF ANEURYSMS 有权
    用于治疗神经系统的内镜聚合物装置

    公开(公告)号：US20120179193A1

    公开(公告)日：2012-07-12

    申请号：US13383588

    申请日：2010-07-13

    申请人： Daniel Cohn ,  Itai Pelled ,  Randa Abbas ,  Ram Malal

    发明人： Daniel Cohn ,  Itai Pelled ,  Randa Abbas ,  Ram Malal

    IPC分类号： A61M29/04

    CPC分类号： A61L31/06 ,  A61F2/945 ,  C08L67/04

    摘要： Novel medical devices and uses thereof for lining a blood vessel and/or treating an aneurysm are disclosed herein. The device comprises a non-metallic expandable tubular structure, implantable in a body vessel and being made, at least in part, from a polymeric system characterized by a stiffness which changes upon stimulation under physiological conditions. Novel polymeric systems are further disclosed herein, which are configured to produce a polymeric material upon stimulation under physiological conditions, such that a stiffness of said polymeric material is higher than a stiffness of said system. Uses of polymer systems in the manufacture of a device are further disclosed.

    摘要翻译： 本文公开了用于衬里血管和/或治疗动脉瘤的新型医疗装置及其用途。 该装置包括可植入体内容器中的至少部分由聚合体系制成的非金属可膨胀管状结构，其特征在于在生理条件下刺激时改变的刚度。 本文进一步公开了新型聚合物体系，其被配置为在生理条件下刺激时产生聚合物材料，使得所述聚合物材料的刚度高于所述系统的刚度。 进一步公开了聚合物体系在制造装置中的用途。

    Intraluminal polymeric devices for the treatment of aneurysms
    2.
    发明授权
    Intraluminal polymeric devices for the treatment of aneurysms 有权
    用于治疗动脉瘤的腔内聚合物装置

    公开(公告)号：US09526813B2

    公开(公告)日：2016-12-27

    申请号：US13383588

    申请日：2010-07-13

    申请人： Daniel Cohn ,  Itai Pelled ,  Randa Abbas ,  Ram Malal

    发明人： Daniel Cohn ,  Itai Pelled ,  Randa Abbas ,  Ram Malal

    IPC分类号： A61M29/04 ,  A61L31/06 ,  A61F2/945

    CPC分类号： A61L31/06 ,  A61F2/945 ,  C08L67/04

    摘要： Novel medical devices and uses thereof for lining a blood vessel and/or treating an aneurysm are disclosed herein. The device comprises a non-metallic expandable tubular structure, implantable in a body vessel and being made, at least in part, from a polymeric system characterized by a stiffness which changes upon stimulation under physiological conditions. Novel polymeric systems are further disclosed herein, which are configured to produce a polymeric material upon stimulation under physiological conditions, such that a stiffness of said polymeric material is higher than a stiffness of said system. Uses of polymer systems in the manufacture of a device are further disclosed.

    摘要翻译： 本文公开了用于衬里血管和/或治疗动脉瘤的新型医疗装置及其用途。 该装置包括可植入体内容器中的至少部分由聚合体系制成的非金属可膨胀管状结构，其特征在于在生理条件下刺激时改变的刚度。 本文进一步公开了新型聚合物体系，其被配置为在生理条件下刺激时产生聚合物材料，使得所述聚合物材料的刚度高于所述系统的刚度。 进一步公开了聚合物体系在制造装置中的用途。

    Perivalvular sealing for transcatheter heart valve
    3.
    发明授权
    Perivalvular sealing for transcatheter heart valve 有权
    经导管心脏瓣膜的瓣周密封

    公开(公告)号：US08795357B2

    公开(公告)日：2014-08-05

    申请号：US13549068

    申请日：2012-07-13

    申请人： Ziv Yohanan ,  Nik Gurovich ,  Bella Felsen ,  Itai Pelled ,  Oded Meiri

    发明人： Ziv Yohanan ,  Nik Gurovich ,  Bella Felsen ,  Itai Pelled ,  Oded Meiri

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2418 ,  A61F2/2436 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/0065 ,  A61F2250/0069

    摘要： The present disclosure is directed to embodiments of catheter-based prosthetic heart valves, and in particular, prosthetic heart valves having sealing devices configured to seal the interface between the prosthetic valve and the surrounding tissue of the native annulus in which the prosthetic valve is implanted. In one embodiment, a prosthetic heart valve includes an annular sealing member that can be placed in a delivery orientation extending axially away from one end of the valve when the valve is in a radially compressed state. When the valve is expanded, the expansion of the frame causes the sealing member to be pulled to an operative orientation covering a portion of the frame. The present disclosure also discloses new mechanisms and techniques for mounting valve leaflets to a frame of a prosthetic heart valve.

    摘要翻译： 本公开涉及基于导管的假体心脏瓣膜的具体实施方式，特别地，具有密封装置的假体心脏瓣膜被配置为密封假体瓣膜和植入人造瓣膜的天然环带的周围组织之间的界面。 在一个实施例中，假体心脏瓣膜包括环形密封构件，当阀处于径向压缩状态时，环形密封构件能够沿轴向远离阀的一端延伸的排放方向放置。 当阀膨胀时，框架的膨胀使得密封构件被拉到覆盖框架的一部分的操作取向。 本公开还公开了将瓣膜瓣安装到假体心脏瓣膜的框架的新机构和技术。

    PERIVALVULAR SEALING FOR TRANSCATHETER HEART VALVE
    6.
    发明申请
    PERIVALVULAR SEALING FOR TRANSCATHETER HEART VALVE 有权
    用于过渡式心脏瓣膜的密封

    公开(公告)号：US20130018458A1

    公开(公告)日：2013-01-17

    申请号：US13549068

    申请日：2012-07-13

    申请人： Ziv Yohanan ,  Nik Gurovich ,  Bella Felsen ,  Itai Pelled ,  Oded Meiri

    发明人： Ziv Yohanan ,  Nik Gurovich ,  Bella Felsen ,  Itai Pelled ,  Oded Meiri

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2418 ,  A61F2/2436 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/0065 ,  A61F2250/0069

    摘要： The present disclosure is directed to embodiments of catheter-based prosthetic heart valves, and in particular, prosthetic heart valves having sealing devices configured to seal the interface between the prosthetic valve and the surrounding tissue of the native annulus in which the prosthetic valve is implanted. In one embodiment, a prosthetic heart valve includes an annular sealing member that can be placed in a delivery orientation extending axially away from one end of the valve when the valve is in a radially compressed state. When the valve is expanded, the expansion of the frame causes the sealing member to be pulled to an operative orientation covering a portion of the frame. The present disclosure also discloses new mechanisms and techniques for mounting valve leaflets to a frame of a prosthetic heart valve.

    摘要翻译： 本公开涉及基于导管的假体心脏瓣膜的具体实施方式，特别地，具有密封装置的假体心脏瓣膜被配置为密封假体瓣膜和植入人造瓣膜的天然环带的周围组织之间的界面。 在一个实施例中，假体心脏瓣膜包括环形密封构件，当阀处于径向压缩状态时，环形密封构件能够沿轴向远离阀的一端延伸的排放方向放置。 当阀膨胀时，框架的膨胀使得密封构件被拉到覆盖框架的一部分的操作取向。 本公开还公开了将瓣膜瓣安装到假体心脏瓣膜的框架的新机构和技术。

    ENCAPSULATED HEART VALVE
    7.
    发明申请
    ENCAPSULATED HEART VALVE 有权
    封闭式心脏瓣膜

    公开(公告)号：US20120296418A1

    公开(公告)日：2012-11-22

    申请号：US13475210

    申请日：2012-05-18

    申请人： Celeste Bonyuet ,  Andrew Walls ,  John F. Migliazza ,  Itai Pelled

    发明人： Celeste Bonyuet ,  Andrew Walls ,  John F. Migliazza ,  Itai Pelled

    IPC分类号： A61F2/24 ,  B23P11/00

    CPC分类号： A61F2/2415 ,  A61F2/24 ,  A61F2/2409 ,  A61F2/2418 ,  A61F2002/0086 ,  Y10T29/49826

    摘要： The present disclosure concerns embodiments of implantable prosthetic devices, and in particular, implantable prosthetic valves, and methods for making such devices. In one aspect, a prosthetic device includes encapsulating layers that extend over a fabric layer and secure the fabric layer to another component of the device. In particular embodiments, the prosthetic device comprises a prosthetic heart valve, and can be configured to be implanted in any of the native heart valves. In addition, the prosthetic heart valve can be, for example, a transcatheter heart valve, a surgical heart valve, or a minimally-invasive heart valve.

    摘要翻译： 本公开涉及可植入假体装置的实施例，特别是可植入假体瓣膜，以及用于制造这种装置的方法。 在一个方面，假体装置包括在织物层上延伸的包封层，并将织物层固定到装置的另一部件上。 在具体实施例中，假体装置包括假体心脏瓣膜，并且可被构造成植入任何天然心脏瓣膜。 此外，假体心脏瓣膜可以是例如经导管心脏瓣膜，手术心脏瓣膜或微创心脏瓣膜。

    Encapsulated heart valve
    8.
    发明授权
    Encapsulated heart valve 有权
    封闭心脏瓣膜

    公开(公告)号：US08945209B2

    公开(公告)日：2015-02-03

    申请号：US13475210

    申请日：2012-05-18

    申请人： Celeste C. Bonyuet ,  Andrew L. Walls ,  John F. Migliazza ,  Itai Pelled

    发明人： Celeste C. Bonyuet ,  Andrew L. Walls ,  John F. Migliazza ,  Itai Pelled

    IPC分类号： A61F2/24 ,  A61F2/00

    CPC分类号： A61F2/2415 ,  A61F2/24 ,  A61F2/2409 ,  A61F2/2418 ,  A61F2002/0086 ,  Y10T29/49826

    摘要： The present disclosure concerns embodiments of implantable prosthetic devices, and in particular, implantable prosthetic valves, and methods for making such devices. In one aspect, a prosthetic device includes encapsulating layers that extend over a fabric layer and secure the fabric layer to another component of the device. In particular embodiments, the prosthetic device comprises a prosthetic heart valve, and can be configured to be implanted in any of the native heart valves. In addition, the prosthetic heart valve can be, for example, a transcatheter heart valve, a surgical heart valve, or a minimally-invasive heart valve.

    摘要翻译： 本公开涉及可植入假体装置的实施例，特别是可植入假体瓣膜，以及用于制造这种装置的方法。 在一个方面，假体装置包括在织物层上延伸的包封层，并将织物层固定到装置的另一部件上。 在具体实施例中，假体装置包括假体心脏瓣膜，并且可被构造成植入任何天然心脏瓣膜。 此外，假体心脏瓣膜可以是例如经导管心脏瓣膜，手术心脏瓣膜或微创心脏瓣膜。