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公开(公告)号：US08546107B2
公开(公告)日：2013-10-01
申请号：US13184474
申请日：2011-07-15
申请人： Daniel J Freeman , Todd Juan , Robert Radinsky
发明人： Daniel J Freeman , Todd Juan , Robert Radinsky
CPC分类号： C12Q1/6886 , C07K14/71 , C12Q2600/106 , C12Q2600/136 , G01N33/57484 , G01N2333/485 , G01N2800/52
摘要： Mutations of the epidermal growth factor receptor (EGFr), of phosphatidylinositol 3′-kinase (“PI3K”), and of B-Raf are described. Methods of treating tumors containing mutated EGFr with human monoclonal antibodies against EGFr are described. Methods and kits for ascertaining the presence of one or more mutant EGFr, mutant PI3K, and/or mutant B-Raf in a sample and for treating disorders or conditions related to the presence of mutant EGFr, mutant PI3K, and/or mutant B-Raf are also described. Methods of treating tumors containing mutant EGFr, mutant PI3K, and/or mutant B-Raf are also described.
摘要翻译： 描述了表皮生长因子受体（EGFr），磷脂酰肌醇3'-激酶（“PI3K”）和B-Raf的突变。 描述了用针对EGFr的人单克隆抗体治疗含有突变的EGFr的肿瘤的方法。 用于确定样品中一种或多种突变EGFr，突变体PI3K和/或突变体B-Raf的存在以及用于治疗与突变型EGFr，突变体PI3K和/或突变型B-Raf的存在相关的病症或病症的方法和试剂盒， 还描述了Raf。 还描述了治疗含有突变体EGFr，突变体PI3K和/或突变体B-Raf的肿瘤的方法。
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公开(公告)号：US07981605B2
公开(公告)日：2011-07-19
申请号：US11361711
申请日：2006-02-23
申请人： Daniel J. Freeman , Todd Juan , Robert Radinsky
发明人： Daniel J. Freeman , Todd Juan , Robert Radinsky
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C07K14/71 , C12Q2600/106 , C12Q2600/136 , G01N33/57484 , G01N2333/485 , G01N2800/52
摘要： Mutations of the epidermal growth factor receptor (EGFr), of phosphatidylinositol 3′-kinase (“Pl3K”), and of B-Raf are described. Methods of treating tumors containing mutated EGFr with human monoclonal antibodies against EGFr are described. Methods and kits for ascertaining the presence of one or more mutant EGFr, mutant Pl3K, and/or mutant B-Raf in a sample and for treating disorders or conditions related to the presence of mutant EGFr, mutant Pl3K, and/or mutant B-Raf are also described. Methods of treating tumors containing mutant EGFr, mutant Pl3K, and/or mutant B-Raf are also described.
摘要翻译： 描述了表皮生长因子受体（EGFr），磷脂酰肌醇3'-激酶（“Pl3K”）和B-Raf的突变。 描述了用针对EGFr的人单克隆抗体治疗含有突变的EGFr的肿瘤的方法。 用于确定样品中一种或多种突变型EGFr，突变型Pl3K和/或突变体B-Raf的存在并用于治疗与突变型EGFr，突变型P13K和/或突变型B-Raf的存在相关的病症或病症的方法和试剂盒， 还描述了Raf。 还描述了治疗含有突变体EGFr，突变体Pl3K和/或突变体B-Raf的肿瘤的方法。
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公开(公告)号：US20070048754A1
公开(公告)日：2007-03-01
申请号：US11361711
申请日：2006-02-23
申请人： Daniel Freeman , Todd Juan , Robert Radinsky
发明人： Daniel Freeman , Todd Juan , Robert Radinsky
IPC分类号： C12Q1/68 , G01N33/567 , C07H21/04 , C12P21/06 , C07K14/71
CPC分类号： C12Q1/6886 , C07K14/71 , C12Q2600/106 , C12Q2600/136 , G01N33/57484 , G01N2333/485 , G01N2800/52
摘要： Mutations of the epidermal growth factor receptor (EGFr), of phosphatidylinositol 3′-kinase (“Pl3K”), and of B-Raf are described. Methods of treating tumors containing mutated EGFr with human monoclonal antibodies against EGFr are described. Methods and kits for ascertaining the presence of one or more mutant EGFr, mutant Pl3K, and/or mutant B-Raf in a sample and for treating disorders or conditions related to the presence of mutant EGFr, mutant Pl3K, and/or mutant B-Raf are also described. Methods of treating tumors containing mutant EGFr, mutant Pl3K, and/or mutant B-Raf are also described.
摘要翻译： 描述了表皮生长因子受体（EGFr），磷脂酰肌醇3'-激酶（“Pl3K”）和B-Raf的突变。 描述了用针对EGFr的人单克隆抗体治疗含有突变的EGFr的肿瘤的方法。 用于确定样品中一种或多种突变型EGFr，突变型Pl3K和/或突变体B-Raf的存在并用于治疗与突变型EGFr，突变型P13K和/或突变型B-Raf的存在相关的病症或病症的方法和试剂盒， 还描述了Raf。 还描述了治疗含有突变体EGFr，突变体Pl3K和/或突变体B-Raf的肿瘤的方法。
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公开(公告)号：US20120264129A1
公开(公告)日：2012-10-18
申请号：US13523174
申请日：2012-06-14
申请人： Daniel Freeman , Todd Juan , Robert Radinsky
发明人： Daniel Freeman , Todd Juan , Robert Radinsky
IPC分类号： C12Q1/68 , G01N33/573
CPC分类号： C12Q1/6886 , C12Q2600/118
摘要： The present application relates to K-ras mutations, to polynucleotides encoding mutant K-ras polypeptides, and to methods of identifying K-ras mutations. The present application also relates to methods of diagnosing cancer; and methods and kits for predicting the usefulness of anti-EGFr specific binding agents in the treatment of tumors.
摘要翻译： 本申请涉及K-ras突变，编码突变型K-ras多肽的多核苷酸以及鉴定K-ras突变的方法。 本申请还涉及诊断癌症的方法; 以及用于预测抗EGFr特异性结合剂在治疗肿瘤中的有用性的方法和试剂盒。
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公开(公告)号：US10030270B2
公开(公告)日：2018-07-24
申请号：US13523174
申请日：2012-06-14
申请人： Daniel Freeman , Todd Juan , Robert Radinsky
发明人： Daniel Freeman , Todd Juan , Robert Radinsky
IPC分类号： A61K39/00 , C12Q1/6886
CPC分类号： C12Q1/6886 , C12Q2600/118
摘要： The present application relates to K-ras mutations, to polynucleotides encoding mutant K-ras polypeptides, and to methods of identifying K-ras mutations. The present application also relates to methods of diagnosing cancer; and methods and kits for predicting the usefulness of anti-EGFr specific binding agents in the treatment of tumors.
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公开(公告)号：US20080293055A1
公开(公告)日：2008-11-27
申请号：US12046319
申请日：2008-03-11
申请人： Daniel FREEMAN , Todd Juan , Robert Radinsky
发明人： Daniel FREEMAN , Todd Juan , Robert Radinsky
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118
摘要： The present application relates to K-ras mutations, to polynucleotides encoding mutant K-ras polypeptides, and to methods of identifying K-ras mutations. The present application also relates to methods of diagnosing cancer; and methods and kits for predicting the usefulness of anti-EGFr specific binding agents in the treatment of tumors.
摘要翻译： 本申请涉及K-ras突变，编码突变型K-ras多肽的多核苷酸以及鉴定K-ras突变的方法。 本申请还涉及诊断癌症的方法; 以及用于预测抗EGFr特异性结合剂在治疗肿瘤中的有用性的方法和试剂盒。
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公开(公告)号：US20110003755A1
公开(公告)日：2011-01-06
申请号：US12728363
申请日：2010-03-22
申请人： Todd Juan
发明人： Todd Juan
CPC分类号： C07K14/4748 , A01K2217/05
摘要： The present invention provides Tumor Endothelial Marker 5α (TEM5α) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing TEM5α polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, or prevention of diseases, disorders, and conditions associated with TEM5α polypeptides.
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公开(公告)号：US08071372B2
公开(公告)日：2011-12-06
申请号：US12853225
申请日：2010-08-09
申请人： Todd Juan
发明人： Todd Juan
CPC分类号： C07K14/4748 , A01K2217/05
摘要： The present invention provides Tumor Endothelial Marker 5α (TEM5α) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing TEM5α polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, or prevention of diseases, disorders, and conditions associated with TEM5α polypeptides.
摘要翻译： 本发明提供了肿瘤内皮标记5α（TEM5α）多肽和编码该多肽的核酸分子。 本发明还提供选择性结合剂，载体，宿主细胞和用于产生TEM5α多肽的方法。 本发明还提供用于诊断，治疗，改善或预防与TEM5α多肽相关的疾病，病症和病症的药物组合物和方法。
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公开(公告)号：US07771965B2
公开(公告)日：2010-08-10
申请号：US10271697
申请日：2002-10-15
申请人： Todd Juan
发明人： Todd Juan
IPC分类号： C12N15/12
CPC分类号： C07K14/4748 , A01K2217/05
摘要： The present invention provides Tumor Endothelial Marker 5α (TEM5α) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing TEM5α polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, or prevention of diseases, disorders, and conditions associated with TEM5α polypeptides.
摘要翻译： 本发明提供了肿瘤内皮标记5α（TEM5α）多肽和编码该多肽的核酸分子。 本发明还提供选择性结合剂，载体，宿主细胞和用于产生TEM5α多肽的方法。 本发明还提供用于诊断，治疗，改善或预防与TEM5α多肽相关的疾病，病症和病症的药物组合物和方法。
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公开(公告)号：US20090053763A1
公开(公告)日：2009-02-26
申请号：US12075311
申请日：2008-03-10
CPC分类号： C07K14/4748 , A61K38/00
摘要： The present invention provides Tumor Endothelial Marker 7α (TEM7α) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing TEM7α polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with TEM7α polypeptides.
摘要翻译： 本发明提供肿瘤内皮标记7α（TEM7alpha）多肽和编码该多肽的核酸分子。 本发明还提供选择性结合剂，载体，宿主细胞和用于产生TEM7alpha多肽的方法。 本发明还提供用于诊断，治疗，改善和/或预防与TEM7alpha多肽相关的疾病，病症和病症的药物组合物和方法。
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