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    Method for Dispensing Ophthalmic Fluid
    2.
    发明申请
    Method for Dispensing Ophthalmic Fluid 有权
    眼科分配方法

    公开(公告)号：US20080197145A1

    公开(公告)日：2008-08-21

    申请号：US12031703

    申请日：2008-02-15

    申请人： Daniel Py ,  Norbert M. Assion ,  Julian V. Chan ,  Joseph M. Ting

    发明人： Daniel Py ,  Norbert M. Assion ,  Julian V. Chan ,  Joseph M. Ting

    IPC分类号： G01F11/00 ,  A61M35/00 ,  B67D5/64

    CPC分类号： A61F9/0008 ,  B05B11/00412 ,  B05B11/0054 ,  B05B11/0072 ,  B05B11/0097 ,  B05B11/3092 ,  B05B11/3094 ,  B65B3/003 ,  B65D81/245 ,  Y10T29/49826

    摘要： An ophthalmic dispenser and method of filling and dispensing fluid stored therein. The dispenser includes a rigid housing defining a fluid-receiving chamber, a flexible bladder receivable within the fluid-receiving chamber, a pump coupled in fluid communication with the fluid-receiving chamber, and a nozzle having a valve defining an annular, axially-extending valve seat, an outlet aperture coupled in fluid communication between the valve seat and the pump, and a flexible valve cover extending about the valve seat and forming an annular, axially-extending interface therebetween. The valve interface is connectable in fluid communication with the outlet aperture, and at least part of the valve cover is movable between (i) a normally closed position with the valve cover engaging the valve seat to close the interface and form a fluid-tight seal therebetween, and (ii) an open position with at least part of the valve cover spaced away from the valve seat in response to pumped fluid flowing through the outlet aperture at a pressure greater than a valve opening pressure to allow the passage of pressurized fluid therebetween. The rigid housing is mountable within a cartridge which, in turn, is mountable within a dispenser housing including an eyelid depressor and a trigger for simultaneously actuating the eyelid depressor and pump.

    摘要翻译： 一种眼科分配器及其中储存和分配液体的方法。 分配器包括限定流体接收室的刚性壳体，可接收在流体接收室内的柔性气囊，与流体接收室流体连通的泵，以及具有限定环形轴向延伸的阀的喷嘴 阀座，连接在阀座和泵之间流体连通的出口孔，以及围绕阀座延伸并在其间形成环形的轴向延伸的接口的柔性阀盖。 阀门接口可与出口孔流体连通，并且阀盖的至少一部分可在（i）常闭位置与阀盖接合阀座之间移动以关闭接口并形成流体密封 ，并且（ii）打开位置，其中阀盖的至少一部分响应于在大于阀打开压力的压力下流过出口孔的泵送流体而与阀座间隔开，以允许加压流体在其间通过 。 刚性壳体可安装在盒中，其又可安装在分配器壳体内，该分配器壳体包括用于同时致动眼睑下压器和泵的眼睑下压器和触发器。

    Fluid Dispenser Having a One-Way Valve, Pump, Variable-Volume Storage Chamber, and a Needle Penetrable and Laser Resealable Portion
    3.
    发明申请
    Fluid Dispenser Having a One-Way Valve, Pump, Variable-Volume Storage Chamber, and a Needle Penetrable and Laser Resealable Portion 有权
    具有单向阀，泵，可变容量存储室和针头可穿透和可激光可再充电部分的流体分配器

    公开(公告)号：US20130175299A1

    公开(公告)日：2013-07-11

    申请号：US13572145

    申请日：2012-08-10

    申请人： Daniel Py ,  Joseph M. Ting

    发明人： Daniel Py ,  Joseph M. Ting

    IPC分类号： B65D83/00

    CPC分类号： B65D83/0055 ,  A61F9/0008 ,  B05B11/00412 ,  B05B11/0072 ,  B05B11/0097 ,  B05B11/3004 ,  B05B11/3074 ,  B05B11/3077 ,  B05B11/3092 ,  B05B11/3094 ,  B65D81/245

    摘要： A dispenser for dispensing a fluid includes a rigid vial that has a main fluid chamber containing a fluid, and a pump assembly that is in fluid communication with the main fluid chamber and is configured to dispense a predetermined quantity of fluid from the main fluid chamber. A flexible bladder is provided which is located within the main fluid chamber and is configured to expand to fill the ullage created within the main fluid chamber during dispensing of fluid by the pump assembly. The resilient bladder tends to force itself outwardly toward the rigid vial and, in turn, increases the pressure within the main fluid chamber in comparison to the interior of the bladder to thereby prevent the ingress of air or vapors through the bladder or otherwise into the main fluid chamber.

    摘要翻译： 用于分配流体的分配器包括具有包含流体的主流体室的刚性小瓶和与主流体室流体连通并被构造成从主流体室分配预定量的流体的泵组件。 提供柔性囊，其位于主流体室内并且构造成膨胀以填充由泵组件分配流体期间在主流体室内产生的空位。 弹性气囊趋于朝向刚性小瓶向外强制，并且与气囊的内部相比增加了主流体室内的压力，从而防止空气或蒸气进入气囊或以其它方式进入主体 流体室。

    Fluid dispenser having a housing and flexible inner bladder
    4.
    发明授权
    Fluid dispenser having a housing and flexible inner bladder 有权
    流体分配器具有壳体和柔性内囊

    公开(公告)号：US07000806B2

    公开(公告)日：2006-02-21

    申请号：US10890465

    申请日：2004-07-12

    申请人： Daniel Py ,  Joseph M. Ting

    发明人： Daniel Py ,  Joseph M. Ting

    IPC分类号： B67D5/042

    CPC分类号： B65D83/0055 ,  A61F9/0008 ,  B05B11/00412 ,  B05B11/0072 ,  B05B11/0097 ,  B05B11/3004 ,  B05B11/3074 ,  B05B11/3077 ,  B05B11/3092 ,  B05B11/3094 ,  B65D81/245

    摘要： A dispenser for dispensing a fluid includes a rigid vial that has a main fluid chamber containing a fluid, and a pump assembly that is in fluid communication with the main fluid chamber and is configured to dispense a predetermined quantity of fluid from the main fluid chamber. A flexible bladder is provided which is located within the main fluid chamber and is configured to expand to fill the ullage created within the main fluid chamber during dispensing of fluid by the pump assembly. The resilient bladder tends to force itself outwardly toward the rigid vial and, in turn, increases the pressure within the main fluid chamber in comparison to the interior of the bladder to thereby prevent the ingress of air or vapors through the bladder or otherwise into the main fluid chamber.

    摘要翻译： 用于分配流体的分配器包括具有包含流体的主流体室的刚性小瓶和与主流体室流体连通并被构造成从主流体室分配预定量的流体的泵组件。 提供柔性囊，其位于主流体室内并且构造成膨胀以填充由泵组件分配流体期间在主流体室内产生的空位。 弹性气囊趋于朝向刚性小瓶向外强制，并且与气囊的内部相比增加了主流体室内的压力，从而防止空气或蒸气进入气囊或以其它方式进入主体 流体室。

    Method for dispensing ophthalmic fluid
    5.
    发明授权
    Method for dispensing ophthalmic fluid 有权
    眼用液分配方法

    公开(公告)号：US08757436B2

    公开(公告)日：2014-06-24

    申请号：US12031703

    申请日：2008-02-15

    申请人： Daniel Py ,  Norbert M. Assion ,  Julian V. Chan ,  Joseph M. Ting

    发明人： Daniel Py ,  Norbert M. Assion ,  Julian V. Chan ,  Joseph M. Ting

    IPC分类号： B67B7/00 ,  B65D88/54 ,  G01F11/00 ,  B67D7/84 ,  B65D47/18 ,  A61M35/00 ,  A61H33/04

    CPC分类号： A61F9/0008 ,  B05B11/00412 ,  B05B11/0054 ,  B05B11/0072 ,  B05B11/0097 ,  B05B11/3092 ,  B05B11/3094 ,  B65B3/003 ,  B65D81/245 ,  Y10T29/49826

    摘要： An ophthalmic dispenser and method of filling and dispensing fluid stored therein. The dispenser includes a rigid housing defining a fluid-receiving chamber, a flexible bladder receivable within the fluid-receiving chamber, a pump coupled in fluid communication with the fluid-receiving chamber, and a nozzle having a valve defining an annular, axially-extending valve seat, an outlet aperture coupled in fluid communication between the valve seat and the pump, and a flexible valve cover extending about the valve seat and forming an annular, axially-extending interface therebetween. The valve interface is connectable in fluid communication with the outlet aperture, and at least part of the valve cover is movable between (i) a normally closed position with the valve cover engaging the valve seat to close the interface and form a fluid-tight seal therebetween, and (ii) an open position with at least part of the valve cover spaced away from the valve seat in response to pumped fluid flowing through the outlet aperture at a pressure greater than a valve opening pressure to allow the passage of pressurized fluid therebetween. The rigid housing is mountable within a cartridge which, in turn, is mountable within a dispenser housing including an eyelid depressor and a trigger for simultaneously actuating the eyelid depressor and pump.

    摘要翻译： 一种眼科分配器及其中储存和分配液体的方法。 分配器包括限定流体接收室的刚性壳体，可接收在流体接收室内的柔性气囊，与流体接收室流体连通的泵，以及具有限定环形轴向延伸的阀的喷嘴 阀座，连接在阀座和泵之间流体连通的出口孔，以及围绕阀座延伸并在其间形成环形的轴向延伸的接口的柔性阀盖。 阀门接口可与出口孔流体连通，并且阀盖的至少一部分可在（i）常闭位置与阀盖接合阀座之间移动以关闭接口并形成流体密封 和（ii）打开位置，其中阀盖的至少一部分响应于泵送的流体以大于阀打开压力的压力流过出口孔而与阀座间隔开，以允许加压流体在其间通过 。 刚性壳体可安装在盒中，其又可安装在分配器壳体内，该分配器壳体包括用于同时致动眼睑下压器和泵的眼睑下压器和触发器。

    Ophthalmic dispenser and associated method
    6.
    发明授权
    Ophthalmic dispenser and associated method 有权
    眼科分配器及相关方法

    公开(公告)号：US07331944B2

    公开(公告)日：2008-02-19

    申请号：US10691270

    申请日：2003-10-21

    申请人： Daniel Py ,  Norbert M. Assion ,  Julian V. Chan ,  Joseph M. Ting

    发明人： Daniel Py ,  Norbert M. Assion ,  Julian V. Chan ,  Joseph M. Ting

    IPC分类号： A61M35/00 ,  B67D5/064

    CPC分类号： A61F9/0008 ,  B05B11/00412 ,  B05B11/0054 ,  B05B11/0072 ,  B05B11/0097 ,  B05B11/3092 ,  B05B11/3094 ,  B65B3/003 ,  B65D81/245 ,  Y10T29/49826

    摘要： An ophthalmic dispenser has a rigid housing defining a fluid-receiving chamber, a flexible bladder receivable within the fluid-receiving chamber, a pump coupled in fluid communication with the fluid-receiving chamber, and a nozzle having a valve defining an annular, axially-extending valve seat, an outlet aperture coupled in fluid communication between the valve seat and the pump, and a flexible valve cover extending about the valve seat and forming an annular, axially-extending interface therebetween. The valve interface is connectable in fluid communication with the outlet aperture, and at least part of the valve cover is movable between (i) a normally closed position with the valve cover engaging the valve seat to close the interface and form a fluid-tight seal therebetween, and (ii) an open position with at least part of the valve cover spaced away from the valve seat in response to pumped fluid flowing through the outlet aperture at a pressure greater than a valve opening pressure to allow the passage of pressurized fluid therebetween. A spring is drivingly connected to the housing and moves at least one of the pump and housing relative to the other to actuate the pump. The rigid housing is mountable within a cartridge which, in turn, is mountable within a dispenser housing including an eyelid depressor and a trigger for simultaneously actuating the eyelid depressor and pump.

    摘要翻译： 眼科分配器具有限定流体接收室的刚性壳体，可接收在流体接收室内的柔性气囊，与流体接收室流体连通的泵，以及具有限定环形轴向 - 延伸阀座，联接在阀座和泵之间流体连通的出口孔以及围绕阀座延伸并在其间形成环形的轴向延伸的接口的柔性阀盖。 阀门接口可与出口孔流体连通，并且阀盖的至少一部分可在（i）常闭位置与阀盖接合阀座之间移动以关闭接口并形成流体密封 ，并且（ii）打开位置，其中阀盖的至少一部分响应于在大于阀打开压力的压力下流过出口孔的泵送流体而与阀座间隔开，以允许加压流体在其间通过 。 弹簧驱动地连接到壳体并且相对于另一个移动泵和壳体中的至少一个以致动泵。 刚性壳体可安装在盒中，其又可安装在分配器壳体内，该分配器壳体包括用于同时致动眼睑下压器和泵的眼睑下压器和触发器。

    Single use connectors
    8.
    发明授权
    Single use connectors 有权

    公开(公告)号：US10426701B2

    公开(公告)日：2019-10-01

    申请号：US15410762

    申请日：2017-01-19

    申请人： Daniel Py

    发明人： Daniel Py

    IPC分类号： A61J1/20 ,  A61M5/162 ,  A61M39/10 ,  A61M39/18 ,  A61M39/26

    摘要： Connector assembly including a piercing member having a flow port therein attached to a first piece, with the piercing member slidingly receivable within a second piece, wherein the piercing member and the second pierce are movable relative to each other between a first position where the second pieces closes the flow port and a second position where the flow port is open. The first piece contains a locking mechanism that lockingly engages with a device when connected thereto, preventing subsequent disconnection of first piece and the device. Upon initial connection of the first piece to the device, the second piece is moved from the first position to the second position.

    Device with closure, one-way valve, and storage chamber and related method
    9.
    发明授权
    Device with closure, one-way valve, and storage chamber and related method 有权

    公开(公告)号：US09737435B2

    公开(公告)日：2017-08-22

    申请号：US13745721

    申请日：2013-01-18

    申请人： Daniel Py

    发明人： Daniel Py

    IPC分类号： A61F9/00 ,  B23P15/00 ,  B05B11/00 ,  B65D83/00

    CPC分类号： A61F9/0008 ,  B05B11/0056 ,  B05B11/0062 ,  B05B11/0067 ,  B05B11/007 ,  B05B11/0097 ,  B23P15/001 ,  B65D83/0022 ,  Y10T29/49412

    摘要： A device has a first part with a valve seat and storage chamber, and a second part with a flexible valve cover and actuator. The storage chamber may be formed from a pre-form blow-molded into a flexible pouch defining a variable-volume storage chamber. The flexible valve cover and valve seat form a normally closed valve seam therebetween. The valve cover is movable in response to fluid at an inlet to the seam exceeding a valve opening pressure of the one-way valve between (i) a normally closed position with valve cover and valve seat in contact with each other and defining the normally closed seam, and (ii) a second position with at least a portion of the valve cover spaced away from the valve seat to allow the fluid to pass through the seam. The one-way valve may have anti-spritz features for using the device to dispense a substance, such as to the eye. The device may contain prostaglandins without the device material absorbing the prostaglandins material and/or without the material being adsorbed into the drug.