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    Intranasal yellow fever vaccination
    3.
    发明授权
    Intranasal yellow fever vaccination 失效
    鼻内黄热疫苗接种

    公开(公告)号：US06337073B1

    公开(公告)日：2002-01-08

    申请号：US09581218

    申请日：2000-06-22

    申请人： Matthias Niedrig ,  Christiane Stahl-Hennig ,  Gerhard Hunsmann

    发明人： Matthias Niedrig ,  Christiane Stahl-Hennig ,  Gerhard Hunsmann

    IPC分类号： A01N6300

    CPC分类号： A61K39/12 ,  A61K9/0043 ,  A61K2039/5254 ,  A61K2039/542 ,  A61K2039/543 ,  A61K2039/544 ,  C12N2770/24134 ,  Y02A50/388

    摘要： The invention relates to vaccine preparations, pharmaceutical preparations and methods for inducing protective immunity in humans using a live, attenuated yellow fever virus of strain D17 preferably administered by an intranasal route of administration. The inventors have also developed an assay for detecting the induction of both the binding and neutralizing antibodies formed in a protective immune response in humans who have received an intranasal vaccine preparation of the kind described.

    摘要翻译： 本发明涉及疫苗制剂，药物制剂和使用活的减毒黄热病毒D17诱导人类保护性免疫的方法，优选通过鼻内给药途径施用。 本发明人还开发了一种用于检测在已经接受所述类型的鼻内疫苗制剂的人中在保护性免疫应答中形成的结合和中和抗体的诱导的测定。

    Vaccination against malignant melanoma using bcg and/or vaccinia
    5.
    发明申请
    Vaccination against malignant melanoma using bcg and/or vaccinia 审中-公开
    使用bcg和/或牛痘疫苗接种恶性黑素瘤

    公开(公告)号：US20110229503A1

    公开(公告)日：2011-09-22

    申请号：US11578544

    申请日：2005-04-15

    申请人： Bernd Krone ,  Gerhard Hunsmann

    发明人： Bernd Krone ,  Gerhard Hunsmann

    IPC分类号： A61K39/00 ,  A61K31/711 ,  A61P37/04 ,  A61P35/00 ,  A61P31/04 ,  A61P31/12

    CPC分类号： A61K39/02 ,  A61K39/002 ,  A61K2039/545 ,  Y02A50/388

    摘要： The present invention relates to a vaccination which reduces the risk to contract melanoma to about half to third and moreover, within a five year period post diagnosis of malignant melanoma the risk to die is reduced to about half as compared to the non-vaccinated individuals.Beyond its effect on melanoma, the vaccination of the invention also may have protective effects against some other malignancies such as cancers of bladder, breast, esophagus, and kidney, against sarcomas and lymphomas, and against a multitude of micro-organisms which can induce severe and lethal infections or allergies.The present invention relates also to the use the yellow fever vaccine for the prophylactic vaccination against a malignancy, in particular melanoma, to the use of some other licensed vaccinations for the prophylactic vaccination against a malignancy, in particular melanoma, and to new synthetic vaccines which use the identified antigenic motifs.

    摘要翻译： 本发明涉及将接种黑素瘤的风险降低到大约一半到三分之一的疫苗接种，此外，在恶性黑素瘤诊断后的五年内，与非接种个体相比，死亡的风险降低到大约一半。 除了其对黑素瘤的作用之外，本发明的疫苗接种还可以对一些其它恶性肿瘤（例如膀胱，乳腺，食道和肾脏的癌症）针对肉瘤和淋巴瘤以及针对可诱导严重的多种微生物具有保护作用 和致命的感染或过敏。 本发明还涉及将黄热病疫苗用于预防性接种恶性肿瘤，特别是黑素瘤的用途，以使用一些其他许可的接种疫苗来预防性接种恶性肿瘤，特别是黑素瘤，以及新的合成疫苗，其中 使用确定的抗原基序。

    Method of treating viral infections in humans and compositions therefor
    6.
    发明授权
    Method of treating viral infections in humans and compositions therefor 失效
    治疗人类病毒感染的方法及其组合物

    公开(公告)号：US4880782A

    公开(公告)日：1989-11-14

    申请号：US41147

    申请日：1987-04-22

    申请人： Fritz Eckstein ,  Gerhard Hunsmann ,  Heinz Hartmann

    发明人： Fritz Eckstein ,  Gerhard Hunsmann ,  Heinz Hartmann

    IPC分类号： C07H19/16

    CPC分类号： A61K31/70 ,  C07H19/16 ,  Y10S514/885

    摘要： A method of treating viral diseases in a human subject is disclosed. The method involves applying effective amounts of the compound: ##STR1## wherein X is an azido group, a methoxy radical or a fluorine atom and B is thymine, uracil, guanine, cytosine, purine or hypoxanthine if X is methoxy or fluorine, and B is guanine, purine or hypoxanthine if X is azido or a pharmaceutically acceptable salt thereof. Also disclosed are compositions and compounds useful in the method.

    摘要翻译： 公开了治疗人类受试者病毒性疾病的方法。 该方法包括施用有效量的化合物：其中X为叠氮基，甲氧基或氟原子，B为胸腺嘧啶，尿嘧啶，鸟嘌呤，胞嘧啶，嘌呤或次黄嘌呤，如果X为甲氧基或氟，B为 如果X是叠氮基，则是鸟嘌呤，嘌呤或次黄嘌呤或其药学上可接受的盐。 还公开了可用于该方法的组合物和化合物。