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1.发明授权Isolated nona- and decapeptides which bind to HLA molecules, and the use thereof 失效分离的与HLA分子结合的非肽和十肽及其用途公开(公告)号：US07713714B2
公开(公告)日：2010-05-11
申请号：US10758673
申请日：2004-01-16
摘要： A method for inducing proliferation of cytolytic T cells is described.
摘要翻译： 描述了诱导溶细胞T细胞增殖的方法。
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2.发明授权Isolated nona- and decapeptides which bind to HLA molecules, and the use thereof 失效分离的与HLA分子结合的非肽和十肽及其用途公开(公告)号：US06277956B1
公开(公告)日：2001-08-21
申请号：US09061388
申请日：1998-04-16
IPC分类号： A61K3804
摘要： Nonapeptides and decapeptides which bind to HLA molecules and provoke proliferation of cytolytic T cells are disclosed. The decapeptides terminate in Valine, and are restricted in their first three amino acid positions. Other useful nonapeptides are also disclosed.
摘要翻译： 公开了结合HLA分子并引发溶细胞T细胞增殖的非肽和十肽。 十肽终止于缬氨酸，并限制在其前三个氨基酸位置。 还公开了其它有用的壬肽。
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3.发明授权Isolated nucleic acid molecules which encode peptides that bind to HLA molecules, and uses thereof 有权编码与HLA分子结合的肽的分离的核酸分子及其用途公开(公告)号：US07344879B2
公开(公告)日：2008-03-18
申请号：US09789649
申请日：2001-02-21
摘要： Nucleic acid molecules which encode decapeptides which are defined by an HLA-A2 binding motif are disclosed. Also disclosed are expression vectors which include these nucleic acid molecules.
摘要翻译： 公开了编码由HLA-A2结合基序定义的十肽的核酸分子。 还公开了包括这些核酸分子的表达载体。
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公开(公告)号：US06384190B1
公开(公告)日：2002-05-07
申请号：US09461083
申请日：1999-12-14
IPC分类号： A01N3734
摘要： Nonapeptides and decapeptides which bind to HLA molecules and provoke proliferation of cytolytic T cells are disclosed. The decapeptides terminate in Valine, and are restricted in their first three amino acid positions. Other useful nonapeptides are also disclosed.
摘要翻译： 公开了结合HLA分子并引发溶细胞T细胞增殖的非肽和十肽。 十肽终止于缬氨酸，并限制在其前三个氨基酸位置。 还公开了其它有用的壬肽。
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5.发明授权Isolated nona- and decapeptides which bind to HLA molecules, and the use thereof 失效分离的与HLA分子结合的非肽和十肽及其用途
公开(公告)号：US06025470A
公开(公告)日：2000-02-15
申请号：US880963
申请日：1997-06-23
摘要： Nonapeptides and decapeptides which bind to HLA molecules and provoke proliferation of cytolytic T cells are disclosed. The decapeptides terminate in Valine, and are restricted in their first three amino acid positions. Other useful nonapeptides are also disclosed.
摘要翻译： 公开了结合HLA分子并引发溶细胞T细胞增殖的非肽和十肽。 十肽终止于缬氨酸，并限制在其前三个氨基酸位置。 还公开了其它有用的壬肽。
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公开(公告)号：US06605711B1
公开(公告)日：2003-08-12
申请号：US09676005
申请日：2000-09-29
IPC分类号： C07H2104
CPC分类号： C07K14/4748 , A61K39/00
摘要： The invention relates to variant peptides which bind to HLA molecules, leading to lysis of cells via cytolytic T cell lines. The variants are based upon NY-ESO-1 peptides. The peptides can be incorporated into immune tetramers, which are useful as T cell sorters.
摘要翻译： 本发明涉及与HLA分子结合的变体肽，导致通过溶细胞T细胞系裂解细胞。 这些变体基于NY-ESO-1肽。 这些肽可以并入免疫四聚体，其可用作T细胞分选机。
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7.发明授权Method for provoking proliferation of cytolytic T cells via the use of decapeptides which complex with HLA-A2 molecules 有权通过使用与HLA-A2分子复合的十肽来诱发溶细胞T细胞增殖的方法公开(公告)号：US06368857B1
公开(公告)日：2002-04-09
申请号：US09412928
申请日：1999-10-05
IPC分类号： C12N502
摘要： Nonapeptides and decapeptides which bind to HLA molecules and provoke proliferation of cytolytic T cells are disclosed. The decapeptides terminate in Valine, and are restricted in their first three amino acid positions. Other useful nonapeptides are also disclosed.
摘要翻译： 公开了结合HLA分子并引发溶细胞T细胞增殖的非肽和十肽。 十肽终止于缬氨酸，并限制在其前三个氨基酸位置。 还公开了其它有用的壬肽。
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8.发明授权Isolated nona-and decapeptides which bind to HLA molecules, and the use thereof 失效与HLA分子结合的分离的九肽和十肽，及其用途公开(公告)号：US06326200B1
公开(公告)日：2001-12-04
申请号：US09099543
申请日：1998-06-18
IPC分类号： C12N508
摘要： Cytolytic T cells specific to complexes J HLA-A2 molecules and peptides are described as are methods for provoking the cytolytic T cells. The peptides of SEQ ID NOS: 13, 14 and 15 are preferred peptides.
摘要翻译： 对复合物特异性的细胞溶解T细胞J HLA-A2分子和肽被描述为引发细胞溶解性T细胞的方法。 SEQ ID NO：13,14和15的肽是优选的肽。
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公开(公告)号：US06417165B1
公开(公告)日：2002-07-09
申请号：US09440621
申请日：1999-11-15
IPC分类号： A61K3808
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , C07K14/47 , C07K16/18
摘要： The invention relates to variant peptides which bind to HLA molecules, leading to lysis of cells via cytolytic T cell lines. The variants are based upon NY-ESO-1 peptides. The peptides can be incorporated into immune tetramers, which are useful as T cell sorters.
摘要翻译： 本发明涉及与HLA分子结合的变体肽，导致通过溶细胞T细胞系裂解细胞。 这些变体基于NY-ESO-1肽。 这些肽可以并入免疫四聚体，其可用作T细胞分选机。
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公开(公告)号：US5827073A
公开(公告)日：1998-10-27
申请号：US498461
申请日：1995-07-05
IPC分类号： G01N33/532 , C07K1/107 , C07K1/13 , C07K7/06 , C07K14/705 , G01N33/534 , G01N33/566
CPC分类号： C07K7/06 , C07K1/1075 , C07K14/705
摘要： The invention relates to methods for making synthetic, photoreactive peptides and their use. A photoreactively labelled amino acid is incorporated into the peptide. The resulting peptide, when compared to the non-labelled form, is not impaired with respect to its ability to bind an MHC molecule.
摘要翻译： 本发明涉及制备合成的光反应性肽及其用途的方法。 将光反应标记的氨基酸并入肽中。 当与非标记形式相比时，所得肽相对于其结合MHC分子的能力不受损害。
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