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1.发明申请REDUCTION OF CARBON DIOXIDE EMISSION DURING ISOPRENE PRODUCTION BY FERMENTATION 审中-公开通过发酵减少异丙酚生产过程中的二氧化碳排放公开(公告)号：US20130280778A1
公开(公告)日：2013-10-24
申请号：US13899419
申请日：2013-05-21
IPC分类号： C12P5/00
CPC分类号： C12P5/007 , C12N1/20 , Y02E50/343
摘要： The present invention provides methods for increasing the amount of isoprene produced by cultured cells with only a minimal increase in carbon dioxide emitted, thereby resulting in process having a greater yield of isoprene relative to carbon dioxide. In addition, the present invention provides compositions that include the cultured cells or isoprene produced there from.
摘要翻译： 本发明提供了增加培养细胞产生的异戊二烯量的方法，其中发射的二氧化碳的增加只有极小的增加，从而导致异戊二烯相对于二氧化碳的产量更高的方法。 此外，本发明提供了包含从其制备的培养细胞或异戊二烯的组合物。
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2.发明申请METHODS FOR INCREASING MICROBIAL PRODUCTION OF ISOPRENE, ISOPRENOIDS, AND ISOPRENOID PRECURSOR MOLECULES USING GLUCOSE AND ACETATE CO-METABOLISM 审中-公开使用葡萄糖和乙酸盐代谢来增加异丙肾上腺素，异丙肾上腺素和异丙肾上腺素分子的微生物生产的方法公开(公告)号：US20140335576A1
公开(公告)日：2014-11-13
申请号：US14279053
申请日：2014-05-15
摘要： Provided herein are methods for the increased production of intracellular acetyl-CoA, mevalonate, isoprenoid precursors, isoprene and/or isoprenoids by recombinant microorganisms via co-metabolism of substrates with varied oxidation levels.
摘要翻译： 本文提供了通过重组微生物通过具有不同氧化水平的底物的共代谢增加细胞内乙酰辅酶A，甲羟戊酸，类异戊二烯前体，异戊二烯和/或类异戊二烯的生产的方法。
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公开(公告)号：US20150031105A1
公开(公告)日：2015-01-29
申请号：US14295184
申请日：2014-06-03
IPC分类号： C12P5/00
CPC分类号： C12P5/007 , Y02E50/343
摘要： The invention provides improved methods for the production of isoprene from biological materials.
摘要翻译： 本发明提供从生物材料生产异戊二烯的改进方法。
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公开(公告)号：US20130164808A1
公开(公告)日：2013-06-27
申请号：US13725929
申请日：2012-12-21
申请人： Danisco US Inc.
发明人： Joseph C. MCAULIFFE , Rachel E. MUIR , Alex T. NIELSEN , Caroline M. PERES , Dmitrii V. VAVILINE , Derek H. WELLS
IPC分类号： C12P5/00
CPC分类号： C12P5/007 , C12N9/1085 , C12N9/88 , C12Y205/01001 , C12Y402/03027 , Y02P20/52
摘要： This invention relates to recombinant microorganisms capable of producing isoprene and isoprene production with the use of such recombinant microorganism with good efficiency. In this invention, functional activity of the ispA gene is altered to reduce the production of isoprenoid molecules in recombinant cells engineered to produce isoprene or in cells otherwise susceptible to isoprenoid accumulation during fermentation. This decreased ispA gene functional activity enables enhanced synthesis of isoprene in a host microorganism.
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公开(公告)号：US20130295633A1
公开(公告)日：2013-11-07
申请号：US13888248
申请日：2013-05-06
申请人： Danisco US Inc.
IPC分类号： C12P5/00
CPC分类号： C12N15/52 , C12N15/635 , C12N15/70 , C12P5/007 , C12P7/42
摘要： Provided herein are improved compositions and methods for the increased production of isoprene. Also provided herein are improved compositions and methods for the increased production of heterologous polypeptides capable of biological activity.
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6.发明申请METHODS FOR INCREASING MICROBIAL PRODUCTION OF ISOPRENE, ISOPRENOIDS, AND ISOPRENOID PRECURSOR MOLECULES USING GLUCOSE AND ACETATE CO-METABOLISM 审中-公开使用葡萄糖和乙酸盐代谢来增加异丙肾上腺素，异丙肾上腺素和异丙肾上腺素分子的微生物生产的方法公开(公告)号：US20130273625A1
公开(公告)日：2013-10-17
申请号：US13646556
申请日：2012-10-05
申请人： Danisco US Inc.
IPC分类号： C12P5/02
摘要： Provided herein are methods for the increased production of intracellular acetyl-CoA, mevalonate, isoprenoid precursors, isoprene and/or isoprenoids by recombinant microorganisms via co-metabolism of substrates with varied oxidation levels.
摘要翻译： 本文提供了通过重组微生物通过具有不同氧化水平的底物的共代谢增加细胞内乙酰辅酶A，甲羟戊酸，类异戊二烯前体，异戊二烯和/或类异戊二烯的生产的方法。
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7.发明申请INCREASED ISOPRENE PRODUCTION USING THE ARCHAEAL LOWER MEVALONATE PATHWAY 审中-公开使用ARCHAEAL LOWER MEVALONATE PATHWAY增加的ISOPRENE生产公开(公告)号：US20150203873A1
公开(公告)日：2015-07-23
申请号：US14323596
申请日：2014-07-03
发明人： Zachary Q. BECK , Anthony R. CALABRIA , Michael C. MILLER , Alex T. NIELSEN , Dmitrii V. VAVILINE
CPC分类号： C12P5/007 , C12N9/1205 , C12N9/88 , C12P9/00 , C12Y207/01036 , C12Y402/03027 , Y02P20/52
摘要： The invention features methods for producing isoprene from cultured cells using a feedback-resistant mevalonate kinase polypeptide, such as an archaeal mevalonate kinase polypeptide. The resulting isoprene compositions may have increased yields and/or purity of isoprene.
摘要翻译： 本发明的特征在于使用反馈抗性甲羟戊酸激酶多肽（例如古细菌甲羟戊酸激酶多肽）从培养细胞产生异戊二烯的方法。 得到的异戊二烯组合物可以具有增加的异戊二烯的产率和/或纯度。
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公开(公告)号：US20130280769A1
公开(公告)日：2013-10-24
申请号：US13730661
申请日：2012-12-28
发明人： Zachary Q. BECK , Anthony R. CALABRIA , Michael C. MILLER , Alex T. NIELSEN , Dmitrii V. VAVILINE
CPC分类号： C12P5/007 , C12N9/1205 , C12N9/88 , C12P9/00 , C12Y207/01036 , C12Y402/03027 , Y02P20/52
摘要： The invention features methods for producing isoprene from cultured cells using a feedback-resistant mevalonate kinase polypeptide, such as an archaeal mevalonate kinase polypeptide. The resulting isoprene compositions may have increased yields and/or purity of isoprene.
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